Search Results - "Journal of clinical pharmacology"

Recent developments of HDAC inhibitors: Emerging indications and novel molecules by Bondarev, Andrey D., Attwood, Misty M., Jonsson, Jörgen, Chubarev, Vladimir N., Tarasov, Vadim V., Schiöth, Helgi B.

“…The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically well established as attractive therapeutic targets. During…”
Get full text

The pharmacokinetics and the pharmacodynamics of cannabinoids by Lucas, Catherine J., Galettis, Peter, Schneider, Jennifer

“…There is increasing interest in the use of cannabinoids for disease and symptom management, but limited information available regarding their pharmacokinetics…”
Get full text

The Medication Adherence Report Scale: A measurement tool for eliciting patients' reports of nonadherence by Chan, Amy Hai Yan, Horne, Rob, Hankins, Matthew, Chisari, Claudia

“…Aims This study aimed to establish the psychometric properties of a questionnaire measure of patients' adherence to medications to elicit patients' report of…”
Get full text

Developmental Changes in Pharmacokinetics and Pharmacodynamics by den Anker, John, Reed, Michael D., Allegaert, Karel, Kearns, Gregory L.

“…Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic…”
Get full text

A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice by Reeve, Emily, Gnjidic, Danijela, Long, Janet, Hilmer, Sarah

“…Aims The aim of this study was to identify what definitions have been published for the term ‘deprescribing’, and determine whether a unifying definition could…”
Get full text

Pharmacology of bisphosphonates by Cremers, Serge, Drake, Matthew T., Ebetino, F. Hal, Bilezikian, John P., Russell, R. Graham G.

“…The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone resorption were first described in the late 1960s. In the 50 years…”
Get full text

The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta‐analysis by Page, Amy T., Clifford, Rhonda M., Potter, Kathleen, Schwartz, Darren, Etherton‐Beer, Christopher D.

“…Aims Deprescribing is a suggested intervention to reverse the potential iatrogenic harms of inappropriate polypharmacy. The review aimed to determine whether…”
Get full text

A systematic review of cannabidiol dosing in clinical populations by Millar, S.A., Stone, N.L., Bellman, Z.D., Yates, A.S., England, T.J., O'Sullivan, S.E.

“…Aims Cannabidiol (CBD) is a cannabis‐derived medicinal product with potential application in a wide‐variety of contexts; however, its effective dose in…”
Get full text

Adverse drug reactions in special populations – the elderly by Davies, E. A., O'Mahony, M. S.

“…The International Conference on Harmonization considers older people a ‘special population’, as they differ from younger adults in terms of comorbidity,…”
Get full text

Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? by Calder, Philip C.

“…Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n‐3 fatty acids found in oily fish and fish oil supplements. These fatty acids are able to…”
Get full text

Immune‐mediated adverse reactions to vaccines by Stone, Cosby A., Rukasin, Christine R.F., Beachkofsky, Thomas M., Phillips, Elizabeth J.

“…Vaccination continues to be the single most important and successful public health intervention, due to its prevention of morbidity and mortality from…”
Get full text

Trends in the prescription of novel oral anticoagulants in UK primary care by Loo, Simone Y., Dell'Aniello, Sophie, Huiart, Laetitia, Renoux, Christel

“…Aims Novel oral anticoagulants (NOACs) are alternatives to vitamin‐K antagonists (VKAs) for the prevention of thromboembolism. It is unclear how NOACs have…”
Get full text

Microtubule destabilising agents: far more than just antimitotic anticancer drugs by Bates, Darcy, Eastman, Alan

“…Vinca alkaloids have been approved as anticancer drugs for more than 50 years. They have been classified as cytotoxic chemotherapy drugs that act during…”
Get full text

Application of PBPK Modeling and Simulation for Regulatory Decision Making and Its Impact on US Prescribing Information: An Update on the 2018‐2019 Submissions to the US FDA's Office of Clinical Pharmacology by Zhang, Xinyuan, Yang, Yuching, Grimstein, Manuela, Fan, Jianghong, Grillo, Joseph A., Huang, Shiew‐Mei, Zhu, Hao, Wang, Yaning

“…Since 2016, results from physiologically based pharmacokinetic (PBPK) analyses have been routinely found in the clinical pharmacology section of regulatory…”
Get full text

Pharmacokinetics of Patisiran, the First Approved RNA Interference Therapy in Patients With Hereditary Transthyretin‐Mediated Amyloidosis by Zhang, Xiaoping, Goel, Varun, Robbie, Gabriel J.

“…Hereditary transthyretin‐mediated (hATTR) amyloidosis is a rare, inherited, progressively debilitating, and often fatal disease caused by deposition of mutated…”
Get full text

Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases by Becker, Bernhard F., Jacob, Matthias, Leipert, Stephanie, Salmon, Andrew H. J., Chappell, Daniel

“…The endothelial glycocalyx has a profound influence at the vascular wall on the transmission of shear stress, on the maintenance of a selective permeability…”
Get full text

The association between medication non‐adherence and adverse health outcomes in ageing populations: A systematic review and meta‐analysis by Walsh, Caroline A., Cahir, Caitriona, Tecklenborg, Sarah, Byrne, Catherine, Culbertson, Michael A., Bennett, Kathleen E.

“…Aims The aim of this systematic review and meta‐analysis was to synthesise the evidence relating to medication non‐adherence and its association with health…”
Get full text

Bioavailability of bioactive food compounds: a challenging journey to bioefficacy by Rein, Maarit J., Renouf, Mathieu, Cruz‐Hernandez, Cristina, Actis‐Goretta, Lucas, Thakkar, Sagar K., da Silva Pinto, Marcia

“…Bioavailability is a key step in ensuring bioefficacy of bioactive food compounds or oral drugs. Bioavailability is a complex process involving several…”
Get full text

AKT in cancer: new molecular insights and advances in drug development by Mundi, Prabhjot S., Sachdev, Jasgit, McCourt, Carolyn, Kalinsky, Kevin

“…The phosphatidylinositol‐3 kinase (PI3K)–AKT pathway is one of the most commonly dysregulated pathways in all of cancer, with somatic mutations, copy number…”
Get full text

Drugs with anticholinergic effects and cognitive impairment, falls and all‐cause mortality in older adults: A systematic review and meta‐analysis by Ruxton, Kimberley, Woodman, Richard J., Mangoni, Arduino A.

“…Aim The aim was to investigate associations between drugs with anticholinergic effects (DACEs) and cognitive impairment, falls and all‐cause mortality in older…”
Get full text