Search Results - "Journal of cell science"

Galectins at a glance by Johannes, Ludger, Jacob, Ralf, Leffler, Hakon

“…Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration,…”
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Microautophagy - distinct molecular mechanisms handle cargoes of many sizes by Schuck, Sebastian

“…Autophagy is fundamental for cell and organismal health. Two types of autophagy are conserved in eukaryotes: macroautophagy and microautophagy. During…”
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p53, cancer and the immune response by Blagih, Julianna, Buck, Michael D, Vousden, Karen H

“…The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by ) has been established in many studies, but it is now clear that…”
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RAS isoforms and mutations in cancer at a glance by Hobbs, G Aaron, Der, Channing J, Rossman, Kent L

“…RAS proteins (KRAS4A, KRAS4B, NRAS and HRAS) function as GDP-GTP-regulated binary on-off switches, which regulate cytoplasmic signaling networks that control…”
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TFEB at a glance by Napolitano, Gennaro, Ballabio, Andrea

“…The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular processes, such as lysosomal biogenesis and autophagy. The…”
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YAP/TAZ functions and their regulation at a glance by Pocaterra, Arianna, Romani, Patrizia, Dupont, Sirio

“…YAP and TAZ proteins are transcriptional coactivators encoded by paralogous genes, which shuttle between the cytoplasm and the nucleus in response to multiple…”
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Nutrient regulation of mTORC1 at a glance by Condon, Kendall J, Sabatini, David M

“…The mechanistic target of rapamycin (mTOR) signaling pathway coordinates environmental and intracellular cues to control eukaryotic cell growth. As a pivot…”
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Survivin at a glance by Wheatley, Sally P, Altieri, Dario C

“…Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is…”
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Mammalian stress granules and P bodies at a glance by Riggs, Claire L, Kedersha, Nancy, Ivanov, Pavel, Anderson, Paul

“…Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-based cellular compartments that assemble in response to stress. SGs and…”
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Inflammasome activation and assembly at a glance by Malik, Ankit, Kanneganti, Thirumala-Devi

“…Inflammasomes are multimeric protein complexes that typically comprise a sensor, an adaptor and the zymogen procaspase-1. An inflammasome assembles in response…”
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New insights into autophagosome-lysosome fusion by Nakamura, Shuhei, Yoshimori, Tamotsu

“…Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is essential for homeostasis in eukaryotic cells. Due to the wide…”
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The myofibroblast at a glance by Pakshir, Pardis, Noskovicova, Nina, Lodyga, Monika, Son, Dong Ok, Schuster, Ronen, Goodwin, Amanda, Karvonen, Henna, Hinz, Boris

“…In 1971, Gabbiani and co-workers discovered and characterized the " " (contraction) in rat wound granulation tissue and, accordingly, named these cells…”
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The actin cortex at a glance by Chugh, Priyamvada, Paluch, Ewa K

“…Precisely controlled cell deformations are key to cell migration, division and tissue morphogenesis, and have been implicated in cell differentiation during…”
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Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a by Liang, Xiaolei, Zhang, Lina, Wang, Shihua, Han, Qin, Zhao, Robert Chunhua

“…Angiogenesis plays crucial roles in various physiological processes including wound healing and tissue repair. It requires a tight interaction between…”
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Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses by Riedl, Angelika, Schlederer, Michaela, Pudelko, Karoline, Stadler, Mira, Walter, Stefanie, Unterleuthner, Daniela, Unger, Christine, Kramer, Nina, Hengstschläger, Markus, Kenner, Lukas, Pfeiffer, Dagmar, Krupitza, Georg, Dolznig, Helmut

“…Three-dimensional (3D) cancer models are used as preclinical systems to mimic physiologic drug responses. We provide evidence for strong changes of…”
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The interplay between exosomes and autophagy - partners in crime by Xu, Jing, Camfield, Robert, Gorski, Sharon M

“…The eukaryotic endomembrane system is a complex series of interconnected membranous organelles that play important roles in responding to stress and…”
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Mechanisms and functions of lysosome positioning by Pu, Jing, Guardia, Carlos M, Keren-Kaplan, Tal, Bonifacino, Juan S

“…Lysosomes have been classically considered terminal degradative organelles, but in recent years they have been found to participate in many other cellular…”
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Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles by Colombo, Marina, Moita, Catarina, van Niel, Guillaume, Kowal, Joanna, Vigneron, James, Benaroch, Philippe, Manel, Nicolas, Moita, Luis F, Théry, Clotilde, Raposo, Graça

“…Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane. The mechanisms involved in…”
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Autophagy-dependent cell death - where, how and why a cell eats itself to death by Bialik, Shani, Dasari, Santosh K, Kimchi, Adi

“…Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of 'Type II autophagic cell death' in 1990. However, this phenomenon…”
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Tenascin-C at a glance by Midwood, Kim S, Chiquet, Matthias, Tucker, Richard P, Orend, Gertraud

“…Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and…”
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