Search Results - "Journal of cardiovascular pharmacology"

Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial by Panahi, Yunes, Kianpour, Parisa, Mohtashami, Reza, Jafari, Ramezan, Simental-Mendía, Luis E, Sahebkar, Amirhossein

“…BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is one of the most common hepatic diseases in the general adult population. Dyslipidemia, hyperuricemia,…”
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G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms by Jean-Charles, Pierre-Yves, Kaur, Suneet, Shenoy, Sudha K

“…β-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic adaptor proteins that were originally discovered for their…”
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Exosomes From Adipose-derived Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Wnt/β-Catenin Signaling Pathway by Cui, Xiaojun, He, Zhangyou, Liang, Zihao, Chen, Zhenyi, Wang, Haifeng, Zhang, Jiankai

“…Mesenchymal stem cells (MSCs) and their secreted exosomes exert a cardioprotective role in jeopardized myocardium. However, the specific effects and underlying…”
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Phase 1B, Randomized, Double-Blinded, Dose Escalation, Single-Center, Repeat Dose Safety and Pharmacodynamics Study of the Oral NLRP3 Inhibitor Dapansutrile in Subjects With NYHA II–III Systolic Heart Failure by Wohlford, George F., Van Tassell, Benjamin W., Billingsley, Hayley E., Kadariya, Dinesh, Canada, Justin M., Carbone, Salvatore, Mihalick, Virginia L., Bonaventura, Aldo, Vecchié, Alessandra, Chiabrando, Juan Guido, Bressi, Edoardo, Thomas, Georgia, Ho, Ai-Chen, Marawan, Amr A., Dell, Megan, Trankle, Cory R., Turlington, Jeremy, Markley, Roshanak, Abbate, Antonio

“…The NLRP3 inflammasome has been implicated in the development and progression of heart failure. The aim of this study was to determine the safety of an oral…”
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Finerenone, a Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Protects From Rat Cardiorenal Injury by Kolkhof, Peter, Delbeck, Martina, Kretschmer, Axel, Steinke, Wolfram, Hartmann, Elke, Bärfacker, Lars, Eitner, Frank, Albrecht-Küpper, Barbara, Schäfer, Stefan

“…Pharmacological blockade of the mineralocorticoid receptor (MR) ameliorates end-organ damage in chronic heart failure. However, the clinical use of available…”
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Role of Hypertension on the Severity of COVID-19: A Review by Peng, Mei, He, Jia, Xue, Ying, Yang, Xue, Liu, Shao, Gong, Zhicheng

“…The novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved into a global pandemic…”
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The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse by Toldo, Stefano, Mauro, Adolfo Gabriele, Cutter, Zachary, Van Tassell, Benjamin W, Mezzaroma, Eleonora, Del Buono, Marco Giuseppe, Prestamburgo, Andrea, Potere, Nicola, Abbate, Antonio

“…BACKGROUND:Activation of the NLRP3 inflammasome is a primary driver of sterile inflammation in response to myocardial ischemia reperfusion. Pharmacologic…”
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Irisin Protects Heart Against Ischemia-Reperfusion Injury Through a SOD2-Dependent Mitochondria Mechanism by Wang, Zhen, Chen, Ken, Han, Yu, Zhu, Hua, Zhou, Xinyu, Tan, Tao, Zeng, Jing, Zhang, Jun, Liu, Yukai, Li, Yu, Yao, Yonggang, Yi, Jianxun, He, Duofen, Zhou, Jingsong, Ma, Jianjie, Zeng, Chunyu

“…Irisin, a muscle-origin protein derived from the extracellular domain of the fibronectin domain-containing 5 protein (FNDC5), has been shown to modulate…”
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Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use by Papp, Zoltán, Agostoni, Piergiuseppe, Alvarez, Julian, Bettex, Dominique, Bouchez, Stefan, Brito, Dulce, Cˇerný, Vladimir, Comin-Colet, Josep, Crespo-Leiro, Marisa G, Delgado, Juan F, Édes, Istvan, Eremenko, Alexander A, Farmakis, Dimitrios, Fedele, Francesco, Fonseca, Cândida, Fruhwald, Sonja, Girardis, Massimo, Guarracino, Fabio, Harjola, Veli-Pekka, Heringlake, Matthias, Herpain, Antoine, Heunks, Leo MA, Husebye, Tryggve, Ivancan, Višnja, Karason, Kristjan, Kaul, Sundeep, Kivikko, Matti, Kubica, Janek, Masip, Josep, Matskeplishvili, Simon, Mebazaa, Alexandre, Nieminen, Markku S, Oliva, Fabrizio, Papp, Julius-Gyula, Parissis, John, Parkhomenko, Alexander, Põder, Pentti, Pölzl, Gerhard, Reinecke, Alexander, Ricksten, Sven-Erik, Riha, Hynek, Rudiger, Alain, Sarapohja, Toni, Schwinger, Robert HG, Toller, Wolfgang, Tritapepe, Luigi, Tschöpe, Carsten, Wikström, Gerhard, von Lewinski, Dirk, Vrtovec, Bojan, Pollesello, Piero

“…Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. Levosimendan was first approved for clinical use in 2000, when authorization was…”
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NLRP3 Inflammasome in Acute Myocardial Infarction by Mauro, Adolfo G, Bonaventura, Aldo, Mezzaroma, Eleonora, Quader, Mohammed, Toldo, Stefano

“…Acute myocardial infarction (AMI) is associated with the induction of a sterile inflammatory response that leads to further injury. The NACHT, leucine-rich…”
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PDSS2 Inhibits the Ferroptosis of Vascular Endothelial Cells in Atherosclerosis by Activating Nrf2 by Yang, Kai, Song, Hejian, Yin, Delu

“…Cardiovascular disease ranks the leading cause of mortality worldwide. Prenyldiphosphate synthase subunits collectively participate in the formation and…”
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A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse by Marchetti, Carlo, Chojnacki, Jeremy, Toldo, Stefano, Mezzaroma, Eleonora, Tranchida, Nicla, Rose, Scott W, Federici, Massimo, Van Tassell, Benjamin W, Zhang, Shijun, Abbate, Antonio

“…BACKGROUND:The formation of the NLRP3 inflammasome in the heart during acute myocardial infarction amplifies the inflammatory response and mediates further…”
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Low-dose Sinapic Acid Abates the Pyroptosis of Macrophages by Downregulation of lncRNA-MALAT1 in Rats With Diabetic Atherosclerosis by Han, Yong, Qiu, Hong, Pei, Xing, Fan, Yigang, Tian, Hongyan, Geng, Jie

“…Pyroptosis is a type of programmed cell death, which has been associated with multiple inflammatory diseases including diabetic atherosclerosis (DA). This…”
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Dapagliflozin Attenuates Contrast-induced Acute Kidney Injury by Regulating the HIF-1α/HE4/NF-κB Pathway by Huang, Xu, Guo, Xiaoxu, Yan, Gaoliang, Zhang, Yang, Yao, Yuyu, Qiao, Yong, Wang, Dong, Chen, Gecai, Zhang, Weiwei, Tang, Chengchun, Cao, Feng

“…Contrast-induced acute kidney injury (CI-AKI) causes clinically acquired nephropathy in patients who undergo coronary interventions. Hypoxic injury to proximal…”
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Panax Notoginseng Saponins Attenuate Myocardial Ischemia-Reperfusion Injury Through the HIF-1α/BNIP3 Pathway of Autophagy by Liu, Xin-Wen, Lu, Meng-Kai, Zhong, Hui-Ting, Wang, Li-Hong, Fu, Yong-Ping

“…BACKGROUND AND OBJECTIVE:Panax Notoginseng Saponins (PNS) is a formula of Chinese medicine commonly used for treating ischemia myocardial in China. However,…”
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Association of SGLT2 Inhibitors With Risk of Atrial Fibrillation and Stroke in Patients With and Without Type 2 Diabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials by Zheng, Ru-Jie, Wang, Yue, Tang, Jun-Nan, Duan, Jie-Ying, Yuan, Ming-Yue, Zhang, Jin-Ying

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors have well-documented effects on reducing hospitalization for heart failure and cardiovascular mortality,…”
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Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation by Lopaschuk, Gary D, Jaswal, Jagdip S

“…Dramatic maturational changes occur in cardiac energy metabolism during cardiac development, differentiation, and postnatal growth. These changes in energy…”
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Fibroblasts and Myofibroblasts: What Are We Talking About? by Baum, Jennifer, Duffy, Heather S

“…Cardiac myocytes, although large enough to make up most of the heart volume, are only a minority of cells within the heart with fibroblasts and blood vessel…”
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Cardiovascular Considerations in Treating Patients With Coronavirus Disease 2019 (COVID-19) by Dixon, Dave L., Van Tassell, Benjamin W., Vecchié, Alessandra, Bonaventura, Aldo, Talasaz, Azita H., Kakavand, Hessam, D'Ascenzo, Fabrizio, Perciaccante, Antonio, Castagno, Davide, Ammirati, Enrico, Biondi-Zoccai, Giuseppe, Stevens, Michael P., Abbate, Antonio

“…A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly across the globe since December 2019. Coronavirus…”
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Inclisiran: A Novel Agent for Lowering Apolipoprotein B-Containing Lipoproteins by Warden, Bruce A., Duell, P. Barton

“…Hypercholesterolemia is a leading cause of cardiovascular morbidity and mortality. Accordingly, efforts to lower apolipoprotein B-containing lipoproteins in…”
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