Search Results - "Journal of Virology"

Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus by Wan, Yushun, Shang, Jian, Graham, Rachel, Baric, Ralph S, Li, Fang

“…Recently, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans similar to those caused by severe acute respiratory…”
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Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry by Wan, Yushun, Shang, Jian, Sun, Shihui, Tai, Wanbo, Chen, Jing, Geng, Qibin, He, Lei, Chen, Yuehong, Wu, Jianming, Shi, Zhengli, Zhou, Yusen, Du, Lanying, Li, Fang

“…Antibody-dependent enhancement (ADE) of viral entry has been a major concern for epidemiology, vaccine development, and antibody-based drug therapy. However,…”
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Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2 by Nguyen, Austin, David, Julianne K, Maden, Sean K, Wood, Mary A, Weeder, Benjamin R, Nellore, Abhinav, Thompson, Reid F

“…Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen A [HLA-A], -B, and -C genes) may affect…”
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TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection by Iwata-Yoshikawa, Naoko, Okamura, Tadashi, Shimizu, Yukiko, Hasegawa, Hideki, Takeda, Makoto, Nagata, Noriyo

“…Transmembrane serine protease TMPRSS2 activates the spike protein of highly pathogenic human coronaviruses such as severe acute respiratory syndrome-related…”
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Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil by Voloch, Carolina M, da Silva Francisco, Jr, Ronaldo, de Almeida, Luiz G P, Cardoso, Cynthia C, Brustolini, Otavio J, Gerber, Alexandra L, Guimarães, Ana Paula de C, Mariani, Diana, da Costa, Raissa Mirella, Ferreira, Jr, Orlando C, Frauches, Thiago Silva, de Mello, Claudia Maria Braga, Leitão, Isabela de Carvalho, Galliez, Rafael Mello, Faffe, Débora Souza, Castiñeiras, Terezinha M P P, Tanuri, Amilcar, de Vasconcelos, Ana Tereza R

“…Almost simultaneously, several studies reported the emergence of novel SARS-CoV-2 lineages characterized by their phylogenetic and genetic distinction (1),…”
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Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV by Lokugamage, Kumari G, Hage, Adam, de Vries, Maren, Valero-Jimenez, Ana M, Schindewolf, Craig, Dittmann, Meike, Rajsbaum, Ricardo, Menachery, Vineet D

“…SARS-CoV-2, a novel coronavirus (CoV) that causes COVID-19, has recently emerged causing an ongoing outbreak of viral pneumonia around the world. While…”
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The Nucleocapsid Protein of SARS-CoV-2: a Target for Vaccine Development by Dutta, Noton K, Mazumdar, Kaushiki, Gordy, James T

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Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures by Vanderheiden, Abigail, Ralfs, Philipp, Chirkova, Tatiana, Upadhyay, Amit A, Zimmerman, Matthew G, Bedoya, Shamika, Aoued, Hadj, Tharp, Gregory M, Pellegrini, Kathryn L, Manfredi, Candela, Sorscher, Eric, Mainou, Bernardo, Lobby, Jenna L, Kohlmeier, Jacob E, Lowen, Anice C, Shi, Pei-Yong, Menachery, Vineet D, Anderson, Larry J, Grakoui, Arash, Bosinger, Steven E, Suthar, Mehul S

“…The newly emerged human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a pandemic of respiratory illness. Current…”
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Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle by Cong, Yingying, Ulasli, Mustafa, Schepers, Hein, Mauthe, Mario, V'kovski, Philip, Kriegenburg, Franziska, Thiel, Volker, de Haan, Cornelis A M, Reggiori, Fulvio

“…Coronavirus (CoV) nucleocapsid (N) proteins are key for incorporating genomic RNA into progeny viral particles. In infected cells, N proteins are present at…”
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Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance by Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.

“…The emergence of coronaviruses (CoVs) into human populations from animal reservoirs has demonstrated their epidemic capability, pandemic potential, and ability…”
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Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43 by Dubé, Mathieu, Le Coupanec, Alain, Wong, Alan H M, Rini, James M, Desforges, Marc, Talbot, Pierre J

“…Human coronaviruses (HCoVs) are recognized respiratory pathogens for which accumulating evidence indicates that in vulnerable patients the infection can cause…”
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Development of a Highly Effective African Swine Fever Virus Vaccine by Deletion of the I177L Gene Results in Sterile Immunity against the Current Epidemic Eurasia Strain by Borca, Manuel V, Ramirez-Medina, Elizabeth, Silva, Ediane, Vuono, Elizabeth, Rai, Ayushi, Pruitt, Sarah, Holinka, Lauren G, Velazquez-Salinas, Lauro, Zhu, James, Gladue, Douglas P

“…African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal disease of domestic pigs that has significant economic consequences…”
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Biology of Zika Virus Infection in Human Skin Cells by Hamel, Rodolphe, Dejarnac, Ophélie, Wichit, Sineewanlaya, Ekchariyawat, Peeraya, Neyret, Aymeric, Luplertlop, Natthanej, Perera-Lecoin, Manuel, Surasombatpattana, Pornapat, Talignani, Loïc, Thomas, Frédéric, Cao-Lormeau, Van-Mai, Choumet, Valérie, Briant, Laurence, Desprès, Philippe, Amara, Ali, Yssel, Hans, Missé, Dorothée

“…Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family, which includes dengue, West Nile, yellow fever, and Japanese encephalitis viruses, that…”
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Susceptibility of white-tailed deer ( Odocoileus virginianus ) to SARS-CoV-2 by Palmer, Mitchell V, Martins, Mathias, Falkenberg, Shollie, Buckley, Alexandra, Caserta, Leonardo C, Mitchell, Patrick K, Cassmann, Eric D, Rollins, Alicia, Zylich, Nancy C, Renshaw, Randall W, Guarino, Cassandra, Wagner, Bettina, Lager, Kelly, Diel, Diego G

“…The origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing the global coronavirus disease 19 (COVID-19) pandemic, remains a…”
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High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses by Shen, Liang, Niu, Junwei, Wang, Chunhua, Huang, Baoying, Wang, Wenling, Zhu, Na, Deng, Yao, Wang, Huijuan, Ye, Fei, Cen, Shan, Tan, Wenjie

“…Coronaviruses (CoVs) act as cross-species viruses and have the potential to spread rapidly into new host species and cause epidemic diseases. Despite the…”
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The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2 by Ogando, Natacha S, Zevenhoven-Dobbe, Jessika C, van der Meer, Yvonne, Bredenbeek, Peter J, Posthuma, Clara C, Snijder, Eric J

“…Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing machinery comprising 16 nonstructural proteins (nsps). The bifunctional…”
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Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance by Agostini, Maria L, Pruijssers, Andrea J, Chappell, James D, Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L, Bluemling, Gregory R, Lockwood, Mark A, Sheahan, Timothy P, Sims, Amy C, Natchus, Michael G, Saindane, Manohar, Kolykhalov, Alexander A, Painter, George R, Baric, Ralph S, Denison, Mark R

“…Coronaviruses (CoVs) have emerged from animal reservoirs to cause severe and lethal disease in humans, but there are currently no FDA-approved antivirals to…”
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Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning? by Jung, Christoph, Kmiec, Dorota, Koepke, Lennart, Zech, Fabian, Jacob, Timo, Sparrer, Konstantin M J, Kirchhoff, Frank

“…Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that…”
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Complexities of Viral Mutation Rates by Peck, Kayla M, Lauring, Adam S

“…Many viruses evolve rapidly. This is due, in part, to their high mutation rates. Mutation rate estimates for over 25 viruses are currently available. Here, we…”
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A Proteomic Atlas of the African Swine Fever Virus Particle by Alejo, Alí, Matamoros, Tania, Guerra, Milagros, Andrés, Germán

“…African swine fever virus (ASFV) is a large and complex DNA virus that causes a highly lethal swine disease for which there is no vaccine available. The ASFV…”
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