Search Results - "Journal of Histochemistry & Cytochemistry"

Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold by Bülow, Roman David, Boor, Peter

“…Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases (CKDs) regardless of the underlying etiology. The hallmark of…”
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TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis by Xu, Fengyun, Liu, Changwei, Zhou, Dandan, Zhang, Lei

“…Transforming growth factor-beta1 (TGF-β1), a key member in the TGF-β superfamily, plays a critical role in the development of hepatic fibrosis. Its expression…”
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Glycosaminoglycan–Protein Interactions: The First Draft of the Glycosaminoglycan Interactome by Vallet, Sylvain D., Clerc, Olivier, Ricard-Blum, Sylvie

“…The six mammalian glycosaminoglycans (GAGs), chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, hyaluronan, and keratan sulfate, are linear…”
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Renal Inflammation and Fibrosis: A Double-edged Sword by Black, Laurence M., Lever, Jeremie M., Agarwal, Anupam

“…Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote regeneration and repair. After renal injury, damaged tissue releases…”
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The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology by Lord, Megan S., Melrose, James, Day, Anthony J., Whitelock, John M.

“…Inter-α-trypsin inhibitor (IαI) family members are ancient and unique molecules that have evolved over several hundred million years of vertebrate evolution…”
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Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity by Frevert, Charles W., Felgenhauer, Jessica, Wygrecka, Malgorzata, Nastase, Madalina V., Schaefer, Liliana

“…It is evident that components of the extracellular matrix (ECM) act as danger-associated molecular patterns (DAMPs) through direct interactions with pattern…”
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Distribution of FcRn Across Species and Tissues by Latvala, Sari, Jacobsen, Bjoern, Otteneder, Michael B., Herrmann, Annika, Kronenberg, Sven

“…The neonatal Fc receptor (FcRn) is a major histocompatibility complex class I type molecule that binds to, transports, and recycles immunoglobulin G (IgG) and…”
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Cell Energy Metabolism and Hyaluronan Synthesis by Caon, Ilaria, Parnigoni, Arianna, Viola, Manuela, Karousou, Evgenia, Passi, Alberto, Vigetti, Davide

“…Hyaluronan (HA) is a linear glycosaminoglycan (GAG) of extracellular matrix (ECM) synthesized by three hyaluronan synthases (HASes) at the plasma membrane…”
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Versican and Versican-matrikines in Cancer Progression, Inflammation, and Immunity by Papadas, Athanasios, Arauz, Garrett, Cicala, Alexander, Wiesner, Joshua, Asimakopoulos, Fotis

“…Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer development, ranging from proliferative signaling, evasion of…”
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Thrombospondin 1 and Its Diverse Roles as a Regulator of Extracellular Matrix in Fibrotic Disease by Murphy-Ullrich, Joanne E.

“…Thrombospondin 1 (TSP1) is a matricellular extracellular matrix protein that has diverse roles in regulating cellular processes important for the pathogenesis…”
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Diabetic Nephropathy and Extracellular Matrix by Kolset, S. O., Reinholt, F. P., Jenssen, T.

“…Diabetic nephropathy (DN) is a serious complication in diabetes. Major typical morphological changes are the result of changes in the extracellular matrix…”
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Assessment of Apoptosis by Immunohistochemistry to Active Caspase-3, Active Caspase-7, or Cleaved PARP in Monolayer Cells and Spheroid and Subcutaneous Xenografts of Human Carcinoma by Bressenot, Aude, Marchal, Sophie, Bezdetnaya, Lina, Garrier, Julie, Guillemin, Francois, Plenat, Francois

“…Immunohistochemistry to active caspase-3, recently recommended for apoptosis detection, is inappropriate to detect apoptosis involving caspase-7. Cleavage of…”
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The Role of Glypicans in Cancer Progression and Therapy by Li, Nan, Spetz, Madeline R., Ho, Mitchell

“…Glypicans are a family of heparan sulfate proteoglycans that are attached to the cell membrane via a glycosylphosphatidylinositol anchor. Glypicans interact…”
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A Systems View of the Heparan Sulfate Interactome by Gómez Toledo, Alejandro, Sorrentino, James T., Sandoval, Daniel R., Malmström, Johan, Lewis, Nathan E., Esko, Jeffrey D.

“…Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains…”
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Analysis of the Glycosaminoglycan Chains of Proteoglycans by Song, Yuefan, Zhang, Fuming, Linhardt, Robert J.

“…Glycosaminoglycans (GAGs) are heterogeneous, negatively charged, macromolecules that are found in animal tissues. Based on the form of component sugar, GAGs…”
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Versican: A Dynamic Regulator of the Extracellular Matrix by Islam, Shamima, Watanabe, Hideto

“…Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the aggrecan/lectican family. In adults, this proteoglycan serves as a…”
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The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development by Mencio, Caitlin P., Hussein, Rowan K., Yu, Panpan, Geller, Herbert M.

“…The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and…”
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Telocytes: An Emerging Component of Stem Cell Niche Microenvironment by Rosa, Irene, Marini, Mirca, Manetti, Mirko

“…Telocytes (TCs) are newly identified interstitial cells characterized by thin and long cytoplasmic processes, called telopodes, which exhibit a distinctive…”
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The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies by Farrugia, Brooke L., Lord, Megan S., Melrose, James, Whitelock, John M.

“…Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation…”
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Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression by Rangarajan, Sunil, Richter, Jillian R., Richter, Robert P., Bandari, Shyam K., Tripathi, Kaushlendra, Vlodavsky, Israel, Sanderson, Ralph D.

“…Both heparanase and syndecan-1 are known to be present and active in disease pathobiology. An important feature of syndecan-1 related to its role in…”
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