Search Results - "Journal of Cancer"

Cancer statistics for the year 2020: An overview by Ferlay, Jacques, Colombet, Murielle, Soerjomataram, Isabelle, Parkin, Donald M., Piñeros, Marion, Znaor, Ariana, Bray, Freddie

“…Our study briefly reviews the data sources and methods used in compiling the International Agency for Research on Cancer (IARC) GLOBOCAN cancer statistics for…”
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Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods by Ferlay, J., Colombet, M., Soerjomataram, I., Mathers, C., Parkin, D.M., Piñeros, M., Znaor, A., Bray, F.

“…Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018…”
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Cytotoxic CD8+ T cells in cancer and cancer immunotherapy by Raskov, Hans, Orhan, Adile, Christensen, Jan Pravsgaard, Gögenur, Ismail

“…The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface…”
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Cancer health disparities in racial/ethnic minorities in the United States by Zavala, Valentina A., Bracci, Paige M., Carethers, John M., Carvajal-Carmona, Luis, Coggins, Nicole B., Cruz-Correa, Marcia R., Davis, Melissa, de Smith, Adam J., Dutil, Julie, Figueiredo, Jane C., Fox, Rena, Graves, Kristi D., Gomez, Scarlett Lin, Llera, Andrea, Neuhausen, Susan L., Newman, Lisa, Nguyen, Tung, Palmer, Julie R., Palmer, Nynikka R., Pérez-Stable, Eliseo J., Piawah, Sorbarikor, Rodriquez, Erik J., Sanabria-Salas, María Carolina, Schmit, Stephanie L., Serrano-Gomez, Silvia J., Stern, Mariana C., Weitzel, Jeffrey, Yang, Jun J., Zabaleta, Jovanny, Ziv, Elad, Fejerman, Laura

“…There are well-established disparities in cancer incidence and outcomes by race/ethnicity that result from the interplay between structural, socioeconomic,…”
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Reprogramming of fatty acid metabolism in cancer by Koundouros, Nikos, Poulogiannis, George

“…A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth,…”
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Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer by Leonetti, Alessandro, Sharma, Sugandhi, Minari, Roberta, Perego, Paola, Giovannetti, Elisa, Tiseo, Marcello

“…Osimertinib is an irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that is highly selective for EGFR-…”
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Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours by Hong, David S., Kang, Yoon-Koo, Borad, Mitesh, Sachdev, Jasgit, Ejadi, Samuel, Lim, Ho Yeong, Brenner, Andrew J., Park, Keunchil, Lee, Jae-Lyun, Kim, Tae-You, Shin, Sangjoon, Becerra, Carlos R., Falchook, Gerald, Stoudemire, Jay, Martin, Desiree, Kelnar, Kevin, Peltier, Heidi, Bonato, Vinicius, Bader, Andreas G., Smith, Susan, Kim, Sinil, O’Neill, Vincent, Beg, Muhammad S.

“…Background In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of…”
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Deep learning in cancer pathology: a new generation of clinical biomarkers by Echle, Amelie, Rindtorff, Niklas Timon, Brinker, Titus Josef, Luedde, Tom, Pearson, Alexander Thomas, Kather, Jakob Nikolas

“…Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers. However, the growing number of these complex biomarkers tends to…”
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Cytokines in clinical cancer immunotherapy by Berraondo, Pedro, Sanmamed, Miguel F., Ochoa, María C, Etxeberria, Iñaki, Aznar, Maria A., Pérez-Gracia, José Luis, Rodríguez-Ruiz, María E., Ponz-Sarvise, Mariano, Castañón, Eduardo, Melero, Ignacio

“…Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the discovery of the potent anti-tumour activities of several pro-inflammatory…”
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In search of definitions: Cancer‐associated fibroblasts and their markers by Nurmik, Martin, Ullmann, Pit, Rodriguez, Fabien, Haan, Serge, Letellier, Elisabeth

“…The tumor microenvironment has been identified as one of the driving factors of tumor progression and invasion. Inside this microenvironment, cancer‐associated…”
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Worldwide burden of cancer attributable to HPV by site, country and HPV type by de Martel, Catherine, Plummer, Martyn, Vignat, Jerome, Franceschi, Silvia

“…HPV is the cause of almost all cervical cancer and is responsible for a substantial fraction of other anogenital cancers and oropharyngeal cancers…”
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The lingering mysteries of metastatic recurrence in breast cancer by Riggio, Alessandra I., Varley, Katherine E., Welm, Alana L.

“…Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic…”
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Mechanisms of resistance to immune checkpoint inhibitors by Jenkins, Russell W, Barbie, David A, Flaherty, Keith T

“…Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown unprecedented clinical activity in several types of cancer and are…”
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IDH mutation in glioma: molecular mechanisms and potential therapeutic targets by Han, Sue, Liu, Yang, Cai, Sabrina J., Qian, Mingyu, Ding, Jianyi, Larion, Mioara, Gilbert, Mark R., Yang, Chunzhang

“…Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular…”
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International trends in hepatocellular carcinoma incidence, 1978–2012 by Petrick, Jessica L., Florio, Andrea A., Znaor, Ariana, Ruggieri, David, Laversanne, Mathieu, Alvarez, Christian S., Ferlay, Jacques, Valery, Patricia C., Bray, Freddie, McGlynn, Katherine A.

“…Primary liver cancer, the major histology of which is hepatocellular carcinoma (HCC), is the second leading cause of cancer death worldwide. We comprehensively…”
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Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression by Groth, Christopher, Hu, Xiaoying, Weber, Rebekka, Fleming, Viktor, Altevogt, Peter, Utikal, Jochen, Umansky, Viktor

“…Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC) differentiate into granulocytes, macrophages and dendritic cells (DCs). This…”
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Efficacy and safety of pembrolizumab for the treatment of advanced biliary cancer: Results from the KEYNOTE‐158 and KEYNOTE‐028 studies by Piha‐Paul, Sarina A., Oh, Do‐Youn, Ueno, Makoto, Malka, David, Chung, Hyun Cheol, Nagrial, Adnan, Kelley, Robin K., Ros, Willeke, Italiano, Antoine, Nakagawa, Kazuhiko, Rugo, Hope S., Braud, Filippo, Varga, Andrea Iolanda, Hansen, Aaron, Wang, Hui, Krishnan, Suba, Norwood, Kevin G., Doi, Toshihiko

“…We present data from patients with advanced biliary tract cancer (BTC) receiving pembrolizumab in the KEYNOTE‐158 (NCT02628067; phase 2) and KEYNOTE‐028…”
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Global trends in colorectal cancer mortality: projections to the year 2035 by Araghi, Marzieh, Soerjomataram, Isabelle, Jenkins, Mark, Brierley, James, Morris, Eva, Bray, Freddie, Arnold, Melina

“…Colorectal cancer (CRC) is the third most common cancer worldwide and the fourth most common cause of cancer death. Predictions of the future burden of the…”
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Risk factors for endometrial cancer: An umbrella review of the literature by Raglan, Olivia, Kalliala, Ilkka, Markozannes, Georgios, Cividini, Sofia, Gunter, Marc J., Nautiyal, Jaya, Gabra, Hani, Paraskevaidis, Evangelos, Martin‐Hirsch, Pierre, Tsilidis, Kostas K., Kyrgiou, Maria

“…Although many risk factors could have causal association with endometrial cancer, they are also prone to residual confounding or other biases which could lead…”
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Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond by Keller, Laura, Belloum, Yassine, Wikman, Harriet, Pantel, Klaus

“…Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The majority of currently available studies on the use of this…”
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