Search Results - "Jourdan, L."

Development and characterization of the mode-of-action of inhibitory and agonist peptides targeting the voltage-gated sodium channel SCN1B beta-subunit by Williams, Zachary J., Alvarez-Laviada, Anita, Hoagland, Daniel, Jourdan, L. Jane, Poelzing, Steven, Gorelik, Julia, Gourdie, Robert G.

“…Cardiac arrhythmia treatment is a clinical challenge necessitating safer and more effective therapies. Recent studies have highlighted the role of the…”
Get full text

The connexin 43 carboxyl terminal mimetic peptide αCT1 prompts differentiation of a collagen scar matrix in humans resembling unwounded skin by Montgomery, Jade, Richardson, William J., Marsh, Spencer, Rhett, J. Matthew, Bustos, Francis, Degen, Katherine, Ghatnekar, Gautam S., Grek, Christina L., Jourdan, L. Jane, Holmes, Jeffrey W., Gourdie, Robert G.

“…Phase II clinical trials have reported that acute treatment of surgical skin wounds with the therapeutic peptide alpha Connexin Carboxy‐Terminus 1 (αCT1)…”
Get full text

Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts by Teng, Allen C. T., Gu, Liyang, Di Paola, Michelle, Lakin, Robert, Williams, Zachary J., Au, Aaron, Chen, Wenliang, Callaghan, Neal I., Zadeh, Farigol Hakem, Zhou, Yu-Qing, Fatah, Meena, Chatterjee, Diptendu, Jourdan, L. Jane, Liu, Jack, Simmons, Craig A., Kislinger, Thomas, Yip, Christopher M., Backx, Peter H., Gourdie, Robert G., Hamilton, Robert M., Gramolini, Anthony O.

“…The intercalated disc (ICD) is a unique membrane structure that is indispensable to normal heart function, yet its structural organization is not completely…”
Get full text

Hybridizing exact methods and metaheuristics: A taxonomy by Jourdan, L., Basseur, M., Talbi, E.-G.

“…The interest about hybrid optimization methods has grown for the last few years. Indeed, more and more papers about cooperation between heuristics and exact…”
Get full text

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury by Jiang, Jingbo, Hoagland, Daniel, Palatinus, Joseph A, He, Huamei, Iyyathurai, Jegan, Jourdan, L Jane, Bultynck, Geert, Wang, Zhen, Zhang, Zhiwei, Schey, Kevin, Poelzing, Steven, McGowan, Francis X, Gourdie, Robert G

“…Background α Carboxyl terminus 1 (αCT1) is a 25-amino acid therapeutic peptide incorporating the zonula occludens-1 (ZO-1)-binding domain of connexin 43 (Cx43)…”
Get full text

Geodynamic models of the West Antarctic Rift system; implications for the mantle thermal state by Harry, Dennis L, Anoka, Jourdan L, Jha, Sumant

“…Two-dimensional finite element models simulating extension of the West Antarctic Rift System (WARS) exhibit three classes of behavior, which are dependent upon…”
Get full text

ENPP1 homozygous stop-loss variant causing generalized arterial calcifications of infancy: About a severe neonatal clinical case by Grosyeux, C., Jourdan, L., Jellimann, J.-M., Grandmougin, A., Bronner, M., Lambert, L., Bonnet, C.

“…Generalized Arterial Calcifications of Infancy (GACI) is an extremely rare autosomal recessive genetic condition, mostly due to pathogenic variations in the…”
Get full text

Exploring sexualized substance use, sexual behaviors and HIV-screening practices in people attending erotic industry shows by Chollier, M., Bonierbale, M., Polesel, J. M., Clergue, F., Maquigneau, A., Micaelli, P., Korchia, T., Jarillot, E., Jourdan, L., Pillas, N., De Wever, R., Enel, P.

“…Previous studies showed that Erotic industry sShows (ES) were appropriate events for sexual health promotion and testing interventions. A cross-sectional…”
Get full text

Cryoinjury models of the adult and neonatal mouse heart for studies of scarring and regeneration by Strungs, Erik G, Ongstad, Emily L, O'Quinn, Michael P, Palatinus, Joseph A, Jourdan, L Jane, Gourdie, Robert G

“…A major limitation in studies of the injured heart is animal-to-animal variability in wound size resulting from commonly used techniques such as left anterior…”
Get more information

Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats by Pierre, F., Tache, S., Guéraud, F., Rerole, A.L., Jourdan, M.-L., Petit, C.

“…Recent epidemiological studies suggest that high meat intake is associated with promotion of colon cancer linked with haem-iron intake. We previously reported…”
Get full text

Extraction and optimization of classification rules for temporal sequences: Application to hospital data by Vandromme, M., Jacques, J., Taillard, J., Hansske, A., Jourdan, L., Dhaenens, C.

“…This study focuses on the problem of supervised classification on heterogeneous temporal data featuring a mixture of attribute types (numeric, binary,…”
Get full text

Clinicopathologic predictors of lymph node metastasis in breast cancer patients according to molecular subtype by Chas, M., Boivin, L., Arbion, F., Jourdan, M.-L., Body, G., Ouldamer, L.

“…We present a large institutional study to determine factors predictive of axillary lymph node (LN) metastasis in breast cancer according to molecular subtype…”
Get full text

Sensitivity and specificity based multiobjective approach for feature selection: Application to cancer diagnosis by García-Nieto, J., Alba, E., Jourdan, L., Talbi, E.

“…The study of the sensitivity and the specificity of a classification test constitute a powerful kind of analysis since it provides specialists with very…”
Get full text

Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding by Ghatnekar, Gautam S, O'Quinn, Michael P, Jourdan, L Jane, Gurjarpadhye, Abhijit A, Draughn, Robert L, Gourdie, Robert G

“…Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing - including scarring. The aim here was to study the effects of a…”
Get more information

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer by Stengel, C, Newman, S P, Day, J M, Chander, S K, Jourdan, F L, Leese, M P, Ferrandis, E, Regis-Lydi, S, Potter, B V L, Reed, M J, Purohit, A, Foster, P A

“…Background: STX2484 is a novel non-steroidal compound with potent anti-proliferative activity. These studies aimed to identify STX2484’s mechanism of action,…”
Get full text

Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones by Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Thomas, Mark P., Hamel, Ernest, Ferrandis, Eric, Mahon, Mary F., Newman, Simon P., Purohit, Atul, Potter, Barry V. L.

“…A SAR translation strategy adopted for the discovery of tetrahydroisoquinolinone (THIQ)‐based steroidomimetic microtubule disruptors has been extended to…”
Get full text

Structure–Activity Relationships of C-17 Cyano-Substituted Estratrienes as Anticancer Agents by Leese, Mathew P, Jourdan, Fabrice L, Gaukroger, Keira, Mahon, Mary F, Newman, Simon P, Foster, Paul A, Stengel, Chloe, Regis-Lydi, Sandra, Ferrandis, Eric, Fiore, Anna Di, De Simone, Giuseppina, Supuran, Claudiu T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

“…The synthesis, SAR, and preclinical evaluation of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as anticancer agents are discussed…”
Get full text

Metaheuristics and cooperative approaches for the Bi-objective Ring Star Problem by Liefooghe, A., Jourdan, L., Talbi, E.-G.

“…This paper presents and investigates different approaches to solve a new bi-objective routing problem called the ring star problem. It consists of locating a…”
Get full text

Impact of pathological complete response to neoadjuvant chemotherapy in invasive breast cancer according to molecular subtype by Cirier, J, Body, G, Jourdan, M-L, Bedouet, L, Fleurier, C, Pilloy, J, Arbion, F, Ouldamer, L

“…The aim of this study was to evaluate the impact of pathological complete response (pCR) on overall survival (OS) and recurrence-free survival (RFS) according…”
Get full text

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure by Dohle, Wolfgang, Jourdan, Fabrice L, Menchon, Grégory, Prota, Andrea E, Foster, Paul A, Mannion, Pascoe, Hamel, Ernest, Thomas, Mark P, Kasprzyk, Philip G, Ferrandis, Eric, Steinmetz, Michel O, Leese, Mathew P, Potter, Barry V. L

“…Quinazolinone-based anticancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series,…”
Get full text