Search Results - "Jourdain, Alexis A."

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation by Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.

“…Oxidative phosphorylation (OXPHOS) is the major pathway for ATP production in humans. Deficiencies in OXPHOS can arise from mutations in either mitochondrial…”
Get full text

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell by Mick, Eran, Titov, Denis V, Skinner, Owen S, Sharma, Rohit, Jourdain, Alexis A, Mootha, Vamsi K

“…Mitochondrial dysfunction is associated with activation of the integrated stress response (ISR) but the underlying triggers remain unclear. We systematically…”
Get full text

Mitochondrial RNA granules: Compartmentalizing mitochondrial gene expression by Jourdain, Alexis A, Boehm, Erik, Maundrell, Kinsey, Martinou, Jean-Claude

“…In mitochondria, DNA replication, gene expression, and RNA degradation machineries coexist within a common nondelimited space, raising the question of how…”
Get full text

GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules by Jourdain, Alexis A., Koppen, Mirko, Wydro, Mateusz, Rodley, Chris D., Lightowlers, Robert N., Chrzanowska-Lightowlers, Zofia M., Martinou, Jean-Claude

“…Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial…”
Get full text

The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules by Zaganelli, Sofia, Rebelo-Guiomar, Pedro, Maundrell, Kinsey, Rozanska, Agata, Pierredon, Sandra, Powell, Christopher A., Jourdain, Alexis A., Hulo, Nicolas, Lightowlers, Robert N., Chrzanowska-Lightowlers, Zofia M., Minczuk, Michal, Martinou, Jean-Claude

“…Mitochondrial gene expression is a fundamental process that is largely dependent on nuclear-encoded proteins. Several steps of mitochondrial RNA processing and…”
Get full text

A Mitochondria-Specific Isoform of FASTK Is Present In Mitochondrial RNA Granules and Regulates Gene Expression and Function by Jourdain, Alexis A., Koppen, Mirko, Rodley, Christopher D., Maundrell, Kinsey, Gueguen, Naïg, Reynier, Pascal, Guaras, Adela M., Enriquez, José A., Anderson, Paul, Simarro, Maria, Martinou, Jean-Claude

“…The mitochondrial genome relies heavily on post-transcriptional events for its proper expression, and misregulation of this process can cause mitochondrial…”
Get full text

CLIC, a tool for expanding biological pathways based on co-expression across thousands of datasets by Li, Yang, Jourdain, Alexis A, Calvo, Sarah E, Liu, Jun S, Mootha, Vamsi K

“…In recent years, there has been a huge rise in the number of publicly available transcriptional profiling datasets. These massive compendia comprise billions…”
Get full text

The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages by Gobelli, Dino, Serrano-Lorenzo, Pablo, Esteban-Amo, María J., Serna, Julia, Pérez-García, M. Teresa, Orduña, Antonio, Jourdain, Alexis A., Martín-Casanueva, Miguel Á., Á. de la Fuente, Miguel, Simarro, María

“…The functions of macrophages are tightly regulated by their metabolic state. However, the role of the mitochondrial electron transport chain (ETC) in…”
Get full text

Cytosine methylation flags mitochondrial RNA for degradation by Recazens, Emeline, Jourdain, Alexis A.

“…Mitochondrial double-stranded RNA (dsRNA) can form spontaneously in mitochondria, blocking mitochondrial gene expression and triggering an immune response. A…”
Get full text

Dead-Seq: Discovering Synthetic Lethal Interactions from Dead Cells Genomics by Blanco-Fernandez, Joan, Jourdain, Alexis A

“…Pooled genetic screens have revolutionized the field of functional genomics, yet perturbations that decrease fitness, such as those leading to synthetic…”
Get more information

MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations by Rath, Sneha, Sharma, Rohit, Gupta, Rahul, Ast, Tslil, Chan, Connie, Durham, Timothy J, Goodman, Russell P, Grabarek, Zenon, Haas, Mary E, Hung, Wendy H W, Joshi, Pallavi R, Jourdain, Alexis A, Kim, Sharon H, Kotrys, Anna V, Lam, Stephanie S, McCoy, Jason G, Meisel, Joshua D, Miranda, Maria, Panda, Apekshya, Patgiri, Anupam, Rogers, Robert, Sadre, Shayan, Shah, Hardik, Skinner, Owen S, To, Tsz-Leung, Walker, Melissa A, Wang, Hong, Ward, Patrick S, Wengrod, Jordan, Yuan, Chen-Ching, Calvo, Sarah E, Mootha, Vamsi K

“…Abstract The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the…”
Get full text

Nucleosides are overlooked fuels in central carbon metabolism by Strefeler, Abigail, Blanco-Fernandez, Joan, Jourdain, Alexis A.

“…Nucleosides and nucleic acids are abundant in our diet, but their nutritional value has been poorly investigated.Nucleosides maintain the viability of cells…”
Get full text

Two-Step Tag-Free Isolation of Mitochondria for Improved Protein Discovery and Quantification by Blanco-Fernandez, Joan, Jourdain, Alexis A

“…Most physiological and disease processes, from central metabolism to immune response to neurodegeneration, involve mitochondria. The mitochondrial proteome is…”
Get more information

The FASTK family of proteins: emerging regulators of mitochondrial RNA biology by Jourdain, Alexis A, Popow, Johannes, de la Fuente, Miguel A, Martinou, Jean-Claude, Anderson, Paul, Simarro, Maria

“…The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its…”
Get full text

Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS by Jourdain, Alexis A., Begg, Bridget E., Mick, Eran, Shah, Hardik, Calvo, Sarah E., Skinner, Owen S., Sharma, Rohit, Blue, Steven M., Yeo, Gene W., Burge, Christopher B., Mootha, Vamsi K.

“…Oxidative phosphorylation (OXPHOS) and glycolysis are the two major pathways for ATP production. The reliance on each varies across tissues and cell states,…”
Get full text

FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain by Boehm, Erik, Zaganelli, Sofia, Maundrell, Kinsey, Jourdain, Alexis A, Thore, Stéphane, Martinou, Jean-Claude

“…FASTK family proteins have been identified as regulators of mitochondrial RNA homeostasis linked to mitochondrial diseases, but much remains unknown about…”
Get full text

Cytosolic N6AMT1- dependent translation supports mitochondrial RNA processing by Foged, Mads M., Recazens, Emeline, Chollet, Sylvain, Lisci, Miriam, Allen, George E., Zinshteyn, Boris, Boutguetait, Doha, Münch, Christian, Mootha, Vamsi K., Jourdain, Alexis A.

“…Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and imbalance in their expression can lead to inborn errors of metabolism,…”
Get full text

Career pathways, part 13 by Jourdain, Alexis A., Wang, Feilong

“…Following one’s passion and curiosity are major drivers for a successful career in science, and finding the right mentors and collaborators is essential in…”
Get full text

Mitochondrial genome copy number variation across tissues in mice and humans by Rath, Sneha P., Gupta, Rahul, Todres, Ellen, Wang, Hong, Jourdain, Alexis A., Ardlie, Kristin G., Calvo, Sarah E., Mootha, Vamsi K.

“…The mammalian mitochondrial genome (mtDNA) is multicopy and its copy number (mtCN) varies widely across tissues, in development and in disease. Here, we…”
Get full text

Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets by Brun, Thierry, Li, Ning, Jourdain, Alexis A, Gaudet, Pascale, Duhamel, Dominique, Meyer, Jérémy, Bosco, Domenico, Maechler, Pierre

“…In pancreatic β-cells, mitochondria play a central role in coupling glucose metabolism to insulin secretion. Chronic exposure of β-cells to metabolic stresses…”
Get full text