Search Results - "Joudeh, Luay I"

Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics by Raducanu, Vlad-Stefan, Tehseen, Muhammad, Al-Amodi, Amani, Joudeh, Luay I., De Biasio, Alfredo, Hamdan, Samir M.

“…The final steps of lagging strand synthesis induce maturation of Okazaki fragments via removal of the RNA primers and ligation. Iterative cycles between…”
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Dynamic structure mediates halophilic adaptation of a DNA polymerase from the deep‐sea brines of the Red Sea by Takahashi, Masateru, Takahashi, Etsuko, Joudeh, Luay I., Marini, Monica, Das, Gobind, Elshenawy, Mohamed M., Akal, Anastassja, Sakashita, Kosuke, Alam, Intikhab, Tehseen, Muhammad, Sobhy, Mohamed A., Stingl, Ulrich, Merzaban, Jasmeen S., Di Fabrizio, Enzo, Hamdan, Samir M.

“…ABSTRACT The deep‐sea brines of the Red Sea are remote and unexplored environments characterized by high temperatures, anoxic water, and elevated…”
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Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1 by Rashid, Fahad, Harris, Paul D, Zaher, Manal S, Sobhy, Mohamed A, Joudeh, Luay I, Yan, Chunli, Piwonski, Hubert, Tsutakawa, Susan E, Ivanov, Ivaylo, Tainer, John A, Habuchi, Satoshi, Hamdan, Samir M

“…Human flap endonuclease 1 (FEN1) and related structure-specific 5'nucleases precisely identify and incise aberrant DNA structures during replication, repair…”
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Sequential and Multistep Substrate Interrogation Provides the Scaffold for Specificity in Human Flap Endonuclease 1 by Sobhy, Mohamed A., Joudeh, Luay I., Huang, Xiaojuan, Takahashi, Masateru, Hamdan, Samir M.

“…Human flap endonuclease 1 (FEN1), one of the structure-specific 5′ nucleases, is integral in replication, repair, and recombination of cellular DNA. The 5′…”
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Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway by Zaher, Manal S, Rashid, Fahad, Song, Bo, Joudeh, Luay I, Sobhy, Mohamed A, Tehseen, Muhammad, Hingorani, Manju M, Hamdan, Samir M

“…Abstract RNA-DNA hybrid primers synthesized by low fidelity DNA polymerase α to initiate eukaryotic lagging strand synthesis must be removed efficiently during…”
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Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem cell rolling by AbuZineh, Karmen, Joudeh, Luay I, Al Alwan, Bader, Hamdan, Samir M, Merzaban, Jasmeen S, Habuchi, Satoshi

“…Hematopoietic stem/progenitor cell (HSPC) homing occurs via cell adhesion mediated by spatiotemporally organized ligand-receptor interactions. Although…”
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