Search Results - "Joshua R. Fletcher"

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota by Fletcher, Joshua R., Pike, Colleen M., Parsons, Ruth J., Rivera, Alissa J., Foley, Matthew H., McLaren, Michael R., Montgomery, Stephanie A., Theriot, Casey M.

“…Clostridioides difficile is a bacterial pathogen that causes a range of clinical disease from mild to moderate diarrhea, pseudomembranous colitis, and toxic…”
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Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies by Chen, Linxiao, Valentine, Jenny L., Huang, Chung-Jr, Endicott, Christine E., Moeller, Tyler D., Rasmussen, Jed A., Fletcher, Joshua R., Boll, Joseph M., Rosenthal, Joseph A., Dobruchowska, Justyna, Wang, Zhirui, Heiss, Christian, Azadi, Parastoo, Putnam, David, Trent, M. Stephen, Jones, Bradley D., DeLisa, Matthew P.

“…The O-antigen polysaccharide (O-PS) component of lipopolysaccharides on the surface of gram-negative bacteria is both a virulence factor and a B-cell antigen…”
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Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse Model by Fletcher, Joshua R, Erwin, Samantha, Lanzas, Cristina, Theriot, Casey M

“…Antibiotics alter the gut microbiota and decrease resistance to Clostridium difficile colonization; however, the mechanisms driving colonization resistance are…”
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Interactions of Francisella tularensis with Alveolar Type II Epithelial Cells and the Murine Respiratory Epithelium by Faron, Matthew, Fletcher, Joshua R, Rasmussen, Jed A, Apicella, Michael A, Jones, Bradley D

“…Francisella tularensis is classified as a Tier 1 select agent by the CDC due to its low infectious dose and the possibility that the organism can be used as a…”
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The Francisella tularensis migR, trmE, and cphA Genes Contribute to F. tularensis Pathogenicity Island Gene Regulation and Intracellular Growth by Modulation of the Stress Alarmone ppGpp by Faron, Matthew, Fletcher, Joshua R, Rasmussen, Jed A, Long, Matthew E, Allen, Lee-Ann H, Jones, Bradley D

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Ability to Acquire Iron Is Inversely Related to Virulence and the Protective Efficacy of Francisella tularensis Live Vaccine Strain by Fletcher, Joshua R, Crane, Deborah D, Wehrly, Tara D, Martens, Craig A, Bosio, Catharine M, Jones, Bradley D

“…is a highly infectious bacterial pathogen that causes the potentially fatal disease tularemia. The Live Vaccine Strain (LVS) of subsp. , while no longer…”
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Knowledge-based information and the effectiveness of R&D in small firms by Fletcher, Joshua C. R., Howard, Eric S., Link, Albert N., O’Connor, Alan C.

“…This paper explores the impact that external sources of information have on the effectiveness of R&D in small, entrepreneurial firms. The effectiveness of R&D…”
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In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials by Selle, Kurt, Fletcher, Joshua R, Tuson, Hannah, Schmitt, Daniel S, McMillan, Lana, Vridhambal, Gowrinarayani S, Rivera, Alissa J, Montgomery, Stephanie A, Fortier, Louis-Charles, Barrangou, Rodolphe, Theriot, Casey M, Ousterout, David G

“…is an important nosocomial pathogen that causes approximately 500,000 cases of infection (CDI) and 29,000 deaths annually in the United States. Antibiotic use…”
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Human fecal metabolomic profiling could inform Clostridioides difficile infection diagnosis and treatment by Theriot, Casey M, Fletcher, Joshua R

“…Clostridioides difficile is a significant public health threat, and diagnosis of this infection is challenging due to a lack of sensitivity in current…”
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Staphylococcus aureus Overcomes Anaerobe-Derived Short-Chain Fatty Acid Stress via FadX and the CodY Regulon by Fletcher, Joshua R, Villareal, Alex R, Penningroth, Mitchell R, Hunter, Ryan C

“…Chronic rhinosinusitis (CRS) is characterized by immune dysfunction, mucus hypersecretion, and persistent infection of the paranasal sinuses. While…”
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High-throughput quantification of microbial-derived organic acids in mucin-rich samples via reverse phase high performance liquid chromatography by Villarreal, Alex R, Lucas, Sarah K, Fletcher, Joshua R, Hunter, Ryan C

“…Organic acids (short chain fatty acids, amino acids, etc.) are common metabolic byproducts of commensal bacteria of the gut and oral cavity in addition to…”
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Inclusion of Epitopes That Expand High-Avidity CD4+ T Cells Transforms Subprotective Vaccines to Efficacious Immunogens against Virulent Francisella tularensis by Roberts, Lydia M, Crane, Deborah D, Wehrly, Tara D, Fletcher, Joshua R, Jones, Bradley D, Bosio, Catharine M

“…T cells are the immunological cornerstone in host defense against infections by intracellular bacterial pathogens, such as virulent Francisella tularensis spp…”
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Bacterial lipoproteins and other factors released by Francisella tularensis modulate human neutrophil lifespan: Effects of a TLR1 SNP on apoptosis inhibition by Kinkead, Lauren C., Whitmore, Laura C., McCracken, Jenna M., Fletcher, Joshua R., Ketelsen, Brandi B., Kaufman, Justin W., Jones, Bradley D., Weiss, David S., Barker, Jason H., Allen, Lee‐Ann H.

“…Francisella tularensis infects several cell types including neutrophils, and aberrant neutrophil accumulation contributes to tissue destruction during…”
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Uncovering the components of the Francisella tularensis virulence stealth strategy by Jones, Bradley D, Faron, Matthew, Rasmussen, Jed A, Fletcher, Joshua R

“…Over the last decade, studies on the virulence of the highly pathogenic intracellular bacterial pathogen Francisella tularensis have increased dramatically…”
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Epigenetic regulation of the calcitonin gene-related peptide gene in trigeminal glia by Park, Ki-Youb, Fletcher, Joshua R, Raddant, Ann C, Russo, Andrew F

“…The neuropeptide calcitonin gene-related peptide (CGRP) plays a key role in migraine. CGRP gene expression involves an enhancer that is active in neurons, yet…”
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Characterization of Francisella tularensis Schu S4 mutants identified from a transposon library screened for O-antigen and capsule deficiencies by Rasmussen, Jed A, Fletcher, Joshua R, Long, Matthew E, Allen, Lee-Ann H, Jones, Bradley D

“…The lipopolysaccharide (LPS) and O-antigen polysaccharide capsule structures of Francisella tularensis play significant roles in helping these highly virulent…”
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Inclusion of epitopes that expand high avidity CD4+ T cells transforms sub-protective vaccines to efficacious immunogens against virulent Francisella tularensis by Roberts, Lydia M, Crane, Deborah D, Wehrly, Tara D, Fletcher, Joshua R, Jones, Bradley D, Bosio, Catharine M

“…T cells are the immunological cornerstone in host defense against infections by intracellular bacterial pathogens, such as virulent Francisella tularensis…”
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Inclusion of non- Francisella epitopes promotes expansion of high avidity, antigen-specific CD4+ T cells for improvement of existing Francisella vaccines by Roberts, Lydia M, Crane, Deborah D, Wehrly, Tara D, Fletcher, Joshua R, Jones, Bradley D, Bosio, Catharine M

“…Abstract Francisella tularensis subsp. tularensis strain SchuS4 (Ftt) is a highly virulent bacterial pathogen and the causative agent of tularemia. There are…”
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italic toggle="yes">In Vivo /italic> Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials by Kurt Selle, Joshua R. Fletcher, Hannah Tuson, Daniel S. Schmitt, Lana McMillan, Gowrinarayani S. Vridhambal, Alissa J. Rivera, Stephanie A. Montgomery, Louis-Charles Fortier, Rodolphe Barrangou, Casey M. Theriot, David G. Ousterout

“…ABSTRACT Clostridioides difficile is an important nosocomial pathogen that causes approximately 500,000 cases of C. difficile infection (CDI) and 29,000 deaths…”
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Interactions of Francisella tularensis with Alveolar Type II Epithelial Cells and the Murine Respiratory Epithelium: e0127458 by Faron, Matthew, Fletcher, Joshua R, Rasmussen, Jed A, Apicella, Michael A, Jones, Bradley D

“…Francisella tularensis is classified as a Tier 1 select agent by the CDC due to its low infectious dose and the possibility that the organism can be used as a…”
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