Search Results - "Joshua, Vijay"
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Mechanisms involved in triggering rheumatoid arthritis
Published in Immunological reviews (01-01-2016)“…Summary Rheumatoid arthritis (RA) is a chronic inflammatory syndrome with a strong autoimmune component. The autoantigens in RA are neither tissue nor…”
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Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts
Published in Annals of the rheumatic diseases (01-12-2019)“…Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) might contribute to bone loss and arthralgia before the onset of joint…”
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The lung microbiota in early rheumatoid arthritis and autoimmunity
Published in Microbiome (17-11-2016)“…Airway abnormalities and lung tissue citrullination are found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. This…”
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Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss
Published in Annals of the rheumatic diseases (01-04-2016)“…Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction…”
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Structural Changes and Antibody Enrichment in the Lungs Are Early Features of Anti–Citrullinated Protein Antibody–Positive Rheumatoid Arthritis
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-01-2014)“…Objective It has been suggested that immunologic events in the lungs may be involved in triggering immunity, in particular production of anti–citrullinated…”
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Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
Published in The Journal of experimental medicine (11-03-2013)“…Antibodies targeting citrullinated proteins (ACPAs [anticitrullinated protein antibodies]) are commonly found in patients with rheumatoid arthritis (RA),…”
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Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-11-2023)“…The lung is implicated as a site for breach of tolerance prior to onset of seropositive rheumatoid arthritis (RA). To substantiate this, we investigated…”
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Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins
Published in Annals of the rheumatic diseases (01-02-2015)“…To investigate the role of genetic and environmental factors in the development of anticitrullinated protein antibodies (ACPA) and ACPA-positive rheumatoid…”
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Presence of anti-modified protein antibodies in idiopathic pulmonary fibrosis
Published in Respirology (Carlton, Vic.) (01-10-2023)“…Studies of autoimmunity and anti-citrullinated protein antibodies (ACPA) in idiopathic pulmonary fibrosis (IPF) have been confined to investigations of…”
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The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients
Published in Arthritis research & therapy (14-09-2021)“…Abstract Background There is a need for biomarker to identify patients “at risk” for rheumatoid arthritis (risk-RA) and to better predict the therapeutic…”
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Evidence of membranolytic targeting and intracellular citrullination in neutrophils isolated from patients with rheumatoid arthritis
Published in Scientific reports (05-07-2024)“…Anti-citrullinated protein autoantibodies (ACPA) are diagnostic for rheumatoid arthritis (RA). The antigens recognized by these autoantibodies are produced by…”
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Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate
Published in Arthritis research & therapy (04-09-2015)“…Receptor activator of nuclear factor kappa B ligand (RANKL) is a key regulator of bone metabolism. Anti-citrullinated protein antibodies (ACPA) have been…”
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Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL
Published in Rheumatic & musculoskeletal diseases open (01-06-2021)“…ObjectivesOur knowledge about the effect of tocilizumab (TCZ) on the synovium in rheumatoid arthritis (RA) is limited. The aim of this study was to investigate…”
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Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells
Published in Arthritis research & therapy (01-12-2016)“…Antibodies against citrullinated proteins (ACPA) are common in patients with rheumatoid arthritis (RA). ACPA can appear before disease onset and target many…”
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Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis
Published in Rheumatic & musculoskeletal diseases open (10-09-2020)“…BackgroundRheumatoid arthritis (RA)-associated anticitrullinated protein/peptide antibodies (ACPA) might originate at mucosal sites such as the lungs. We aimed…”
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Aspiration during Rapid Sequence Induction: Prevalence and Risk Factors
Published in Indian journal of critical care medicine (01-02-2021)“…Securing definitive airway with minimal complications is a challenging task for high-volume emergency departments (ED) that deal with patients with compromised…”
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A Chemist with a Strange Etiology of Rhabdomyolysis: A Case Report of a Rare Toxicological Emergency
Published in Clinical practice and cases in emergency medicine (01-11-2021)“…Chloroform, a halogenated hydrocarbon, causes central nervous depression, hepatotoxicity, nephrotoxicity, and rhabdomyolysis. Historically, chloroform had been…”
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Impact of lockdown and unlocking on symptomatology and emergency department visits during the first wave of the COVID-19 pandemic
Published in Journal of family medicine and primary care (01-03-2022)“…Background: The COVID-19 pandemic resulted in a complete nationwide lockdown on March 24, 2020. The months of April and May had stringent lockdown measures…”
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This Article Corrects: "A Chemist with a Strange Etiology of Rhabdomyolysis: A Case Report of a Rare Toxicological Emergency"
Published in Clinical practice and cases in emergency medicine (01-02-2022)“…n/a…”
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