Search Results - "Joshi, Samit"

Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial by Morales-Ramirez, Javier, Bogner, Johannes R, Molina, Jean-Michel, Lombaard, Johan, Dicker, Ira B, Stock, David A, DeGrosky, Michelle, Gartland, Margaret, Pene Dumitrescu, Teodora, Min, Sherene, Llamoso, Cyril, Joshi, Samit R, Lataillade, Max

“…GSK3532795 (formerly known as BMS-955176) is a second-generation maturation inhibitor targeting a specific Gag cleavage site between capsid p24 and spacer…”
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Viral Drug Resistance through 48 Weeks, in a Phase 2b, Randomized, Controlled Trial of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir by Lataillade, Max, Zhou, Nannan, Joshi, Samit R, Lee, Sangil, Stock, David A, Hanna, George J, Krystal, Mark

“…ABSTRACT [Journal limit250 words, currently 250] BACKGROUND:Fostemsavir is a prodrug of temsavir, an attachment inhibitor that binds to HIV-1 gp120, blocking…”
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A Phase I Evaluation of the Pharmacokinetics and Tolerability of the HIV-1 Maturation Inhibitor GSK3640254 and Tenofovir Alafenamide/Emtricitabine in Healthy Participants by Pene Dumitrescu, Teodora, Joshi, Samit R, Xu, Jianfeng, Zhan, Joyce, Johnson, Mark, Butcher, Laurie, Zimmerman, Eric, Webster, Lindsey, Davidson, Antonia M, Lataillade, Max, Min, Sherene

“…GSK3640254 is a next-generation maturation inhibitor that would likely be combined with standard antiretroviral agents to form a regimen of ≥2 fully active…”
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Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254 by Spinner, Christoph D, Felizarta, Franco, Rizzardini, Giuliano, Philibert, Patrick, Mitha, Essack, Domingo, Pere, Stephan, Christoph J, DeGrosky, Michelle, Bainbridge, Veronica, Zhan, Joyce, Dumitrescu, Teodora Pene, Jeffrey, Jerry L, Xu, Jianfeng, Halliday, Fiona, Gan, Jianjun, Johnson, Mark, Gartland, Martin, Joshi, Samit R, Lataillade, Max

“…GSK3640254 (GSK'254) is a next-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor with pharmacokinetics (PK) supporting once-daily…”
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Dysregulation of human Toll-like receptor function in aging by Shaw, Albert C, Panda, Alexander, Joshi, Samit R, Qian, Feng, Allore, Heather G, Montgomery, Ruth R

“…Research highlights ► Dysregulation of Toll-like receptor function occurs in aging humans. ► Adjustment for potential confounding factors is critical in human…”
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Phase I evaluation of pharmacokinetics and tolerability of the HIV‐1 maturation inhibitor GSK3640254 and dolutegravir in healthy adults by Pene Dumitrescu, Teodora, Joshi, Samit R., Xu, Jianfeng, Greene, Thomas J., Johnson, Mark, Butcher, Laurie, Zimmerman, Eric, Webster, Lindsey, Pham, Theresa T., Lataillade, Max, Min, Sherene

“…Aims GSK3640254, a novel, next‐generation maturation inhibitor effective against a range of HIV polymorphisms with no cross‐resistance to current…”
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Lack of pharmacokinetic interaction between the HIV‐1 maturation inhibitor GSK3640254 and combination oral contraceptives in healthy women by Pene Dumitrescu, Teodora, Greene, Thomas J., Joshi, Samit R., Xu, Jianfeng, Johnson, Mark, Halliday, Fiona, Butcher, Laurie, Zimmerman, Eric, Webster, Lindsey, Pham, Theresa T., Lataillade, Max, Min, Sherene

“…Aims GSK3640254 is a next‐generation maturation inhibitor likely to be coadministered with combined oral contraceptives in HIV‐positive women. Methods This…”
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Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation by Xu, Dongyi, Shen, Weiping, Guo, Rong, Xue, Yutong, Peng, Wei, Sima, Jian, Yang, Jay, Sharov, Alexei, Srikantan, Subramanya, Yang, Jiandong, Fox, David, Qian, Yong, Martindale, Jennifer L, Piao, Yulan, Machamer, James, Joshi, Samit R, Mohanty, Subhasis, Shaw, Albert C, Lloyd, Thomas E, Brown, Grant W, Ko, Minoru S H, Gorospe, Myriam, Zou, Sige, Wang, Weidong

“…Topoisomerases are thought to work in DNA, but not RNA, metabolism. Here Xu et al . describe that Top3A can also act as an RNA topoisomerase and find it in a…”
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Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults by Chou, Chih‐Hung, Mohanty, Subhasis, Kang, Heather A., Kong, Lingjia, Avila‐Pacheco, Julian, Joshi, Samit R., Ueda, Ikuyo, Devine, Lesley, Raddassi, Khadir, Pierce, Kerry, Jeanfavre, Sarah, Bullock, Kevin, Meng, Hailong, Clish, Clary, Santori, Fabio R., Shaw, Albert C., Xavier, Ramnik J.

“…Seasonal influenza causes mild to severe respiratory infections and significant morbidity, especially in older adults. Transcriptomic analysis in populations…”
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Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study by Dicker, Ira, Zhang, Sharon, Ray, Neelanjana, Beno, Brett R, Regueiro-Ren, Alicia, Joshi, Samit, Cockett, Mark, Krystal, Mark, Lataillade, Max

“…GSK3532795 (formerly BMS955176) is a second-generation maturation inhibitor (MI) that progressed through a Phase 2b study for treatment of HIV-1 infection…”
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Prolonged Proinflammatory Cytokine Production in Monocytes Modulated by Interleukin 10 After Influenza Vaccination in Older Adults by Mohanty, Subhasis, Joshi, Samit R., Ueda, Ikuyo, Wilson, Jean, Blevins, Tamara P., Siconolfi, Barbara, Meng, Hailong, Devine, Lesley, Raddassi, Khadir, Tsang, Sui, Belshe, Robert B., Hafler, David A., Kaech, Susan M., Kleinstein, Steven H., Trentalange, Mark, Allore, Heather G., Shaw, Albert C.

“…We evaluated in vivo innate immune responses in monocyte populations from 67 young (aged 21-30 years) and older (aged ≥65 years) adults before and after…”
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Multiple network-constrained regressions expand insights into influenza vaccination responses by Avey, Stefan, Mohanty, Subhasis, Wilson, Jean, Zapata, Heidi, Joshi, Samit R, Siconolfi, Barbara, Tsang, Sui, Shaw, Albert C, Kleinstein, Steven H

“…Systems immunology leverages recent technological advancements that enable broad profiling of the immune system to better understand the response to infection…”
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Relative Bioavailability and Food Effect of GSK3640254 Tablet and Capsule Formulations in Healthy Participants by Johnson, Mark, Pene Dumitrescu, Teodora, Joshi, Samit R., Mathew, Ashwin, Bainbridge, Veronica, Zhan, Joyce, Lataillade, Max

“…GSK3640254 is a next‐generation maturation inhibitor with demonstrated potency across HIV‐1 subtypes and a high barrier to emergent resistance. This phase I,…”
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Exploring HIV-1 Maturation: A New Frontier in Antiviral Development by McGraw, Aidan, Hillmer, Grace, Medehincu, Stefania M, Hikichi, Yuta, Gagliardi, Sophia, Narayan, Kedhar, Tibebe, Hasset, Marquez, Dacia, Mei Bose, Lilia, Keating, Adleigh, Izumi, Coco, Peese, Kevin, Joshi, Samit, Krystal, Mark, DeCicco-Skinner, Kathleen L, Freed, Eric O, Sardo, Luca, Izumi, Taisuke

“…HIV-1 virion maturation is an essential step in the viral replication cycle to produce infectious virus particles. Gag and Gag-Pol polyproteins are assembled…”
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Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next‐generation HIV‐1 maturation inhibitor by Joshi, Samit R., Fernando, Disala, Igwe, Stephanie, McKenzie, Litza, Krishnatry, Anu S., Halliday, Fiona, Zhan, Joyce, Greene, Thomas J., Xu, Jianfeng, Ferron‐Brady, Geraldine, Lataillade, Max, Min, Sherene

“…Despite advances in HIV‐1 management with antiretroviral therapy, drug resistance and toxicities with multidrug regimens can result in treatment failure…”
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Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants by Zhang, Ying, Bush, Mark, Yazdani, Parto, Zhan, Joyce, Wen, Bo, Bainbridge, Veronica, Wynne, Brian R., Joshi, Samit, Lataillade, Max

“…GSK3640254 (GSK'254) is a novel HIV‐1 maturation inhibitor with pharmacokinetics supporting once‐daily (QD) therapy for HIV‐1 treatment. This thorough…”
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Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination by Thakar, Juilee, Mohanty, Subhasis, West, A Phillip, Joshi, Samit R, Ueda, Ikuyo, Wilson, Jean, Meng, Hailong, Blevins, Tamara P, Tsang, Sui, Trentalange, Mark, Siconolfi, Barbara, Park, Koonam, Gill, Thomas M, Belshe, Robert B, Kaech, Susan M, Shadel, Gerald S, Kleinstein, Steven H, Shaw, Albert C

“…To elucidate gene expression pathways underlying age-associated impairment in influenza vaccine response, we screened young (age 21-30) and older (age≥65)…”
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Safety and efficacy of the HIV-1 attachment inhibitor prodrug BMS-663068 in treatment-experienced individuals: 24 week results of AI438011, a phase 2b, randomised controlled trial by Lalezari, Jacob P, Dr, Latiff, Gulam H, MD, Brinson, Cynthia, MD, Echevarría, Juan, MD, Treviño-Pérez, Sandra, MD, Bogner, Johannes R, Prof, Thompson, Melanie, MD, Fourie, Jan, MD, Sussmann Pena, Otto A, MD, Mendo Urbina, Fernando C, MD, Martins, Marcelo, MD, Diaconescu, Iulian G, MD, Stock, David A, PhD, Joshi, Samit R, DO, Hanna, George J, MD, Lataillade, Max, DO

“…Summary Background BMS-663068 is an oral prodrug of BMS-626529, an attachment inhibitor that binds to HIV-1 gp120, blocking viral attachment to host CD4 cells…”
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Safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in antiretroviral-experienced subjects: week 48 analysis of AI438011, a Phase IIb, randomized controlled trial by Thompson, Melanie, Lalezari, Jacob P, Kaplan, Richard, Pinedo, Yvett, Pena, Otto A Sussmann, Cahn, Pedro, Stock, David A, Joshi, Samit R, Hanna, George J, Lataillade, Max

“…Fostemsavir is a prodrug of temsavir, an attachment inhibitor that binds directly to HIV-1 gp120, blocking initial viral attachment and entry into host CD4…”
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Multicolor Digital Flow Cytometry in Human Translational Immunology by Joshi, Samit R, Mohanty, Subhasis, Shaw, Albert C

“…By facilitating the simultaneous analysis of parameters from diverse cell lineages and biological pathways, multicolor flow cytometry is integral to many…”
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