Evidence-Based Management of Postoperative Pain in Adults Undergoing Laparoscopic Sleeve Gastrectomy

Evidence-Based Management of Postoperative Pain in Adults Undergoing Laparoscopic Sleeve Gastrectomy

Background Laparoscopic sleeve gastrectomy (LSG) is a common weight loss operation that is increasingly being managed on an outpatient or overnight stay basis. The aim of this systematic review was to evaluate the available literature and develop recommendations for optimal pain management after LSG...

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Bibliographic Details
Published in:World journal of surgery Vol. 43; no. 6; pp. 1571 - 1580
Main Authors: Macfater, Hoani, Xia, Weisi, Srinivasa, Sanket, Hill, Andrew Graham, Van De Velde, Marc, Joshi, Girsh P.
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 15-06-2019
Springer Nature B.V
Subjects:
Abdominal Surgery
Acetaminophen
Adrenergic alpha-2 Receptor Agonists - therapeutic use
Adults
Analgesia, Epidural
Analgesics
Analgesics, Non-Narcotic - therapeutic use
Anesthetics, Local
Anti-inflammatory agents
Anti-Inflammatory Agents - therapeutic use
Cardiac Surgery
Dexamethasone
English language
Gastrectomy
Gastrectomy - methods
General Surgery
Heterogeneity
Humans
Infiltration
Inflammation
Laparoscopy
Laparoscopy - methods
Literature reviews
Magnesium
Management
Medicine
Medicine & Public Health
Narcotics
Nerve Block
Nonsteroidal anti-inflammatory drugs
Opioids
Pain
Pain management
Pain, Postoperative - therapy
Postoperative period
Randomized Controlled Trials as Topic
Reviews
Scientific Review
Surgery
Systematic review
Thoracic Surgery
Tramadol
Vascular Surgery
Weight loss
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Summary:Background Laparoscopic sleeve gastrectomy (LSG) is a common weight loss operation that is increasingly being managed on an outpatient or overnight stay basis. The aim of this systematic review was to evaluate the available literature and develop recommendations for optimal pain management after LSG. Methods A systematic review utilizing preferred reporting items for systematic reviews and meta-analysis with PROcedure SPECific Postoperative Pain ManagemenT methodology was undertaken. Randomized controlled trials (RCTs) published in the English language from inception to September 2018 assessing postoperative pain using analgesic, anesthetic, and surgical interventions were identified from MEDLINE, EMBASE and Cochrane Databases. Results Significant heterogeneity was identified in the 18 RCTs included in this systematic review. Gabapentinoids and transversus abdominis plane blocks reduced LSG postoperative pain. There was limited procedure-specific evidence of analgesic effects for acetaminophen, non-steroidal anti-inflammatory drugs, dexamethasone, magnesium, and tramadol in this setting. Inconsistent evidence was found in the studies investigating alpha-2-agonists. No evidence was found for intraperitoneal local anesthetic administration or single-port laparoscopy. Conclusions The literature to recommend an optimal analgesic regimen for LSG is limited. The pragmatic view supports acetaminophen and a non-steroidal anti-inflammatory drug, with opioids as rescue analgesics. Gabapentinoids should be used with caution, as they may amplify opioid-induced respiratory depression. Although transversus abdominis plane blocks reduced pain, port-site infiltration may be considered instead, as it is a simple and inexpensive approach that provides adequate somatic blockade. Further RCTs are required to confirm the influence of the recommended analgesic regimen on postoperative pain relief.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-019-04934-y