Search Results - "Joshi, Amrita"

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms by Davis, Frank M, Tsoi, Lam C, Melvin, William J, denDekker, Aaron, Wasikowski, Rachael, Joshi, Amrita D, Wolf, Sonya, Obi, Andrea T, Billi, Allison C, Xing, Xianying, Audu, Christopher, Moore, Bethany B, Kunkel, Steven L, Daugherty, Alan, Lu, Hong S, Gudjonsson, Johann E, Gallagher, Katherine A

“…Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing aortic rupture. During AAA…”
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A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis by Oak, Sameer R, Murray, Lynne, Herath, Athula, Sleeman, Matthew, Anderson, Ian, Joshi, Amrita D, Coelho, Ana Lucia, Flaherty, Kevin R, Toews, Galen B, Knight, Darryl, Martinez, Fernando J, Hogaboam, Cory M

“…Idiopathic pulmonary fibrosis exhibits differential progression from the time of diagnosis but the molecular basis for varying progression rates is poorly…”
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The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair by Kimball, Andrew S., Davis, Frank M., denDekker, Aaron, Joshi, Amrita D., Schaller, Matthew A., Bermick, Jennifer, Xing, Xianying, Burant, Charles F., Obi, Andrea T., Nysz, Dylan, Robinson, Scott, Allen, Ron, Lukacs, Nicholas W., Henke, Peter K., Gudjonsson, Johann E., Moore, Bethany B., Kunkel, Steve L., Gallagher, Katherine A.

“…Macrophage plasticity is critical for normal tissue repair to ensure transition from the inflammatory to the proliferative phase of healing. We examined…”
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Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing by Davis, Frank M, Schaller, Matthew A, Dendekker, Aaron, Joshi, Amrita D, Kimball, Andrew S, Evanoff, Holly, Wilke, Carol, Obi, Andrea T, Melvin, William J, Cavassani, Karen, Scola, Melissa, Carson, Beau, Moser, Stephanie, Blanc, Victoria, Engoren, Milo, Moore, Bethany B, Kunkel, Steven L, Gallagher, Katherine A

“…OBJECTIVE:Sepsis represents an acute life-threatening disorder resulting from a dysregulated host response. For patients who survive sepsis, there remains…”
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Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes by Gallagher, Katherine A, Joshi, Amrita, Carson, William F, Schaller, Matthew, Allen, Ronald, Mukerjee, Sumanta, Kittan, Nico, Feldman, Eva L, Henke, Peter K, Hogaboam, Cory, Burant, Charles F, Kunkel, Steven L

“…Classically activated (M1) macrophages are known to play a role in the development of chronic inflammation associated with impaired wound healing in type 2…”
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Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing by Davis, Frank M., denDekker, Aaron, Joshi, Amrita D., Wolf, Sonya J., Audu, Christopher, Melvin, William J., Mangum, Kevin, Riordan, Mary O., Kunkel, Steven L., Gallagher, Katherine A.

“…Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized…”
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Murine macrophage chemokine receptor CCR2 plays a crucial role in macrophage recruitment and regulated inflammation in wound healing by Boniakowski, Anna E., Kimball, Andrew S., Joshi, Amrita, Schaller, Matt, Davis, Frank M., denDekker, Aaron, Obi, Andrea T, Moore, Bethany B., Kunkel, Steve L., Gallagher, Katherine A.

“…Macrophages play a critical role in the establishment of a regulated inflammatory response following tissue injury. Following injury, CCR2+ monocytes are…”
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Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair by Audu, Christopher O., Melvin, William J., Joshi, Amrita D., Wolf, Sonya J., Moon, Jadie Y., Davis, Frank M., Barrett, Emily C., Mangum, Kevin D., Deng, Hongping, Xing, Xianying, Wasikowski, Rachel, Tsoi, Lam C., Sharma, Sriganesh B., Bauer, Tyler M., Shadiow, James, Corriere, Matthew A., Obi, Andrea T., Kunkel, Steven L., Levi, Benjamin, Moore, Bethany B., Gudjonsson, Johann E., Smith, Andrew M., Gallagher, Katherine A.

“…Macrophage plasticity is critical for normal tissue repair following injury. In pathologic states such as diabetes, macrophage plasticity is impaired, and…”
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The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages by Carson, 4th, William F, Cavassani, Karen A, Soares, Elyara M, Hirai, Soichiro, Kittan, Nicolai A, Schaller, Matthew A, Scola, Melissa M, Joshi, Amrita, Matsukawa, Akihiro, Aronoff, David M, Johnson, Craig N, Dou, Yali, Gallagher, Katherine A, Kunkel, Steven L

“…Macrophages are critical immune cells for the clearance of microbial pathogens and cellular debris from peripheral tissues. Macrophage inflammatory responses…”
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The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development by Davis, Frank M, Melvin, William J, Mangum, Kevin, Tsoi, Lam C, Joshi, Amrita D, Cai, Qing, Henke, Peter K, Gudjonsson, Johann E, Gallagher, Katherine A

“…To determine macrophage-specific alterations in epigenetic enzyme function contributing to the development of abdominal aortic aneurysms (AAAs). AAA is a…”
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The Histone Methyltransferase MLL1 Directs Macrophage-Mediated Inflammation in Wound Healing and Is Altered in a Murine Model of Obesity and Type 2 Diabetes by Kimball, Andrew S, Joshi, Amrita, Carson, 4th, William F, Boniakowski, Anna E, Schaller, Matthew, Allen, Ronald, Bermick, Jennifer, Davis, Frank M, Henke, Peter K, Burant, Charles F, Kunkel, Steve L, Gallagher, Katherine A

“…Macrophages are critical for the initiation and resolution of the inflammatory phase of wound repair. In diabetes, macrophages display a prolonged inflammatory…”
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Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair by Davis, Frank M, denDekker, Aaron, Kimball, Andrew, Joshi, Amrita D, El Azzouny, Mahmoud, Wolf, Sonya J, Obi, Andrea T, Lipinski, Jay, Gudjonsson, Johann E, Xing, Xianying, Plazyo, Olesya, Audu, Christopher, Melvin, William J, Singer, Kanakadurga, Henke, Peter K, Moore, Bethany B, Burant, Charles, Kunkel, Steven L, Gallagher, Katherine A

“…Macrophages are critical for the initiation and resolution of the inflammatory phase of wound healing. In diabetes, macrophages display a prolonged…”
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Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing by Kimball, Andrew S, Joshi, Amrita D, Boniakowski, Anna E, Schaller, Matthew, Chung, Jooho, Allen, Ronald, Bermick, Jennifer, Carson, 4th, William F, Henke, Peter K, Maillard, Ivan, Kunkel, Steve L, Gallagher, Katherine A

“…Macrophages are essential immune cells necessary for regulated inflammation during wound healing. Recent studies have identified that Notch plays a role in…”
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Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling by Wolf, Sonya J, Audu, Christopher O, Moon, Jadie Y, Joshi, Amrita D, Melvin, William J, Barrett, Emily C, Mangum, Kevin, de Jimenez, Gabriela Saldana, Rocco, Sabrina, Buckley, Sam, Ahmed, Zara, Wasikowski, Rachael, Kahlenberg, J Michelle, Tsoi, Lam C, Gudjonsson, Johann E, Gallagher, Katherine A

“…Macrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist in a low-grade inflammatory state that prevents…”
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Histone Methylation Directs Myeloid TLR4 Expression and Regulates Wound Healing following Cutaneous Tissue Injury by Davis, Frank M, Kimball, Andrew, denDekker, Aaron, Joshi, Amrita D, Boniakowski, Anna E, Nysz, Dylan, Allen, Ronald M, Obi, Andrea, Singer, Kanakadurga, Henke, Peter K, Moore, Bethany B, Kunkel, Steven L, Gallagher, Katherine A

“…Myeloid cells are critical for orchestrating regulated inflammation during wound healing. TLRs, particularly TLR4, and its downstream-signaling MyD88 pathway…”
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Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection by Byrne, Brenda G, Dubuisson, Jean-Francois, Joshi, Amrita D, Persson, Jenny J, Swanson, Michele S

“…When microbes contaminate the macrophage cytoplasm, leukocytes undergo a proinflammatory death that is initiated by nucleotide-binding-domain-,…”
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Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages by Joshi, Amrita D, Oak, Sameer R, Hartigan, Adam J, Finn, William G, Kunkel, Steven L, Duffy, Karen E, Das, Anuk, Hogaboam, Cory M

“…Interleukin-33 is a member of the IL-1 cytokine family whose functions are mediated and modulated by the ST2 receptor. IL-33-ST2 expression and interactions…”
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TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis by Trujillo, Glenda, Meneghin, Alessia, Flaherty, Kevin R, Sholl, Lynette M, Myers, Jeffrey L, Kazerooni, Ella A, Gross, Barry H, Oak, Sameer R, Coelho, Ana Lucia, Evanoff, Holly, Day, Elizabeth, Toews, Galen B, Joshi, Amrita D, Schaller, Matthew A, Waters, Beatrice, Jarai, Gabor, Westwick, John, Kunkel, Steven L, Martinez, Fernando J, Hogaboam, Cory M

“…Idiopathic pulmonary fibrosis is characterized by diffuse alveolar damage and severe fibrosis, resulting in a steady worsening of lung function and gas…”
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Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages by Murray, Lynne A, Rosada, Rogerio, Moreira, Ana Paula, Joshi, Amrita, Kramer, Michael S, Hesson, David P, Argentieri, Rochelle L, Mathai, Susan, Gulati, Mridu, Herzog, Erica L, Hogaboam, Cory M

“…Macrophages promote tissue remodeling but few mechanisms exist to modulate their activity during tissue fibrosis. Serum amyloid P (SAP), a member of the…”
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The histone methyltransferase mixed-lineage-leukemia-1 drives T cell phenotype via notch signaling in diabetic tissue repair by Melvin, William J, Bauer, Tyler M, Magnum, Kevin D, Audu, Christopher O, Shadiow, James, Barrett, Emily, Joshi, Amrita, Moon, Jadie Y, Bogel, Rachel, Mazumder, Purba, Wolf, Sonya J, Kunkel, Steven, Gudjonsson, Johann E, Davis, Frank M, Gallagher, Katherine A

“…Immune cell mediated inflammation is important in normal tissue regeneration but can be pathologic in diabetic wounds. Limited literature exists on the role of…”
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