Search Results - "Joshi, Amar"

Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis by Chaudhari, Nutan, Findlay, Alison D., Stevenson, Andrew W., Clemons, Tristan D., Yao, Yimin, Joshi, Amar, Sayyar, Sepidar, Wallace, Gordon, Rea, Suzanne, Toshniwal, Priyanka, Deng, Zhenjun, Melton, Philip E., Hortin, Nicole, Iyer, K. Swaminathan, Jarolimek, Wolfgang, Wood, Fiona M., Fear, Mark W.

“…Scarring is a lifelong consequence of skin injury, with scar stiffness and poor appearance presenting physical and psychological barriers to a return to normal…”
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Evaluation of Antibiotic Prophylaxis for Acute Nonoperative Orbital Fractures by Esce, Antoinette R., Chavarri, Vanina M., Joshi, Amar B., Meiklejohn, Duncan A.

“…The use of antibiotic prophylaxis for the prevention of infection in nonoperative orbital fractures is controversial, with limited high-quality evidence and…”
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Author Correction: Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis by Chaudhari, Nutan, Findlay, Alison D., Stevenson, Andrew W., Clemons, Tristan D., Yao, Yimin, Joshi, Amar, Sayyar, Sepidar, Wallace, Gordon, Rea, Suzanne, Toshniwal, Priyanka, Deng, Zhenjun, Melton, Philip E., Hortin, Nicole, Iyer, K. Swaminathan, Jarolimek, Wolfgang, Wood, Fiona M., Fear, Mark W.

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Structural and biophysical analysis of nuclease protein antibiotics by Klein, Alexander, Wojdyla, Justyna Aleksandra, Joshi, Amar, Josts, Inokentijs, McCaughey, Laura C, Housden, Nicholas G, Kaminska, Renata, Byron, Olwyn, Walker, Daniel, Kleanthous, Colin

“…Protein antibiotics (bacteriocins) are a large and diverse family of multidomain toxins that kill specific Gram-negative bacteria during intraspecies…”
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Defining the roles and interactions of PTB by Kafasla, Panagiota, Mickleburgh, Ian, Llorian, Miriam, Coelho, Miguel, Gooding, Clare, Cherny, Dmitry, Joshi, Amar, Kotik-Kogan, Olga, Curry, Stephen, Eperon, Ian C, Jackson, Richard J, Smith, Christopher W J

“…PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein with four RRM (RNA recognition motif) domains. PTB is…”
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Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing by Joshi, Amar, Coelho, Miguel B., Kotik-Kogan, Olga, Simpson, Peter J., Matthews, Stephen J., Smith, Christopher W.J., Curry, Stephen

“…The polypyrimidine tract-binding protein (PTB) is an important regulator of alternative splicing. PTB-regulated splicing of α-tropomyosin is enhanced by…”
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DNA Cross-linking, Double-Strand Breaks, and Apoptosis in Corneal Endothelial Cells after a Single Exposure to Mitomycin C by Roh, Danny S, Cook, Amanda L, Rhee, Steven S, Joshi, Amar, Kowalski, Regis, Dhaliwal, Deepinder K, Funderburgh, James L

“…To investigate the cellular effects of mitomycin C (MMC) treatment on corneal endothelial (CE) cells at clinically relevant applications and dosages. Radial…”
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Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB) by Joshi, Amar, Esteve, Vicent, Buckroyd, Adrian N, Blatter, Markus, Allain, Frédéric H-T, Curry, Stephen

“…The eukaryotic polypyrimidine tract binding protein (PTB) serves primarily as a regulator of alternative splicing of messenger RNA, but is also co-opted to…”
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Measurement of Collagen Cross-Links from Tissue Samples by Mass Spectrometry by Joshi, Amar, Zahoor, Amna, Buson, Alberto

“…All tissues contain an extracellular matrix (ECM) which is constantly and dynamically remodeled, either in physiological or pathological processes, such as…”
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Exploitation of an iron transporter for bacterial protein antibiotic import by White, Paul, Joshi, Amar, Rassam, Patrice, Housden, Nicholas G., Kaminska, Renata, Goult, Jonathan D., Redfield, Christina, McCaughey, Laura C., Walker, Daniel, Mohammed, Shabaz, Kleanthous, Colin

“…Unlike their descendants, mitochondria and plastids, bacteria do not have dedicated protein import systems. However, paradoxically, import of protein…”
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The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis by Schilter, Heidi, Findlay, Alison D., Perryman, Lara, Yow, Tin T., Moses, Joshua, Zahoor, Amna, Turner, Craig I., Deodhar, Mandar, Foot, Jonathan S., Zhou, Wenbin, Greco, Angelique, Joshi, Amar, Rayner, Benjamin, Townsend, Sarah, Buson, Alberto, Jarolimek, Wolfgang

“…Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue…”
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Manufacturing a chimpanzee adenovirus‐vectored SARS‐CoV‐2 vaccine to meet global needs by Joe, Carina C. D., Jiang, Jinlin, Linke, Thomas, Li, Yuanyuan, Fedosyuk, Sofiya, Gupta, Gaurav, Berg, Adam, Segireddy, Rameswara R., Mainwaring, David, Joshi, Amar, Cashen, Paul, Rees, Byron, Chopra, Nitin, Nestola, Piergiuseppe, Humphreys, Jonathan, Davies, Sarah, Smith, Nick, Bruce, Scott, Verbart, Dennis, Bormans, Daan, Knevelman, Carol, Woodyer, Mark, Davies, Lee, Cooper, Lisa, Kapanidou, Maria, Bleckwenn, Nicole, Pappas, Daniel, Lambe, Teresa, Smith, Daniel C., Green, Catherine M., Venkat, Raghavan, Ritchie, Adam J., Gilbert, Sarah C., Turner, Richard, Douglas, Alexander D.

“…Manufacturing has been the key factor limiting rollout of vaccination during the COVID‐19 pandemic, requiring rapid development and large‐scale implementation…”
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Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects by Arrington, Eulette D, Caldwell, M.Craig, Kumaravel, T.S, Lohani, Althaf, Joshi, Amar, Evans, Michele K, Chen, Hua Tang, Nussenzweig, Andre, Holbrook, Nikki J, Gorospe, Myriam

“…While the Ku complex, comprised of Ku70 and Ku80, is primarily involved in the repair of DNA double-strand breaks, it is also believed to participate in…”
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Evaluation of Antibiotic Prophylaxis for Acute Nonoperative Orbital Fractures by Esce, Antoinette R., Chavarri, Vanina M., Joshi, Amar B., Meiklejohn, Duncan A.

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A501 Variation in Pre-Operative Clinical Characteristics by Health Insurance Among Women Undergoing Sleeve Gastrectomy by Rattu, Mohammad, Joshi, Amar, Nguyen, Long, Tyrrell, Jessica, Zucconi, Nicole, Slotman, Gus

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Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease by Colombano, Giampiero, Caldwell, John J, Matthews, Thomas P, Bhatia, Chitra, Joshi, Amar, McHardy, Tatiana, Mok, Ngai Yi, Newbatt, Yvette, Pickard, Lisa, Strover, Jade, Hedayat, Somaieh, Walton, Michael I, Myers, Stephanie M, Jones, Alan M, Saville, Harry, McAndrew, Craig, Burke, Rosemary, Eccles, Suzanne A, Davies, Faith E, Bayliss, Richard, Collins, Ian

“…A series of imidazo­[1,2-b]­pyridazin-8-amine kinase inhibitors were discovered to allosterically inhibit the endoribonuclease function of the dual…”
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Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5‑b]pyridine Derivatives as Highly Selective Inhibitors of Aurora‑A Kinase in Cells by Bavetsias, Vassilios, Faisal, Amir, Crumpler, Simon, Brown, Nathan, Kosmopoulou, Magda, Joshi, Amar, Atrash, Butrus, Pérez-Fuertes, Yolanda, Schmitt, Jessica A, Boxall, Katherine J, Burke, Rosemary, Sun, Chongbo, Avery, Sian, Bush, Katherine, Henley, Alan, Raynaud, Florence I, Workman, Paul, Bayliss, Richard, Linardopoulos, Spiros, Blagg, Julian

“…Aurora-A differs from Aurora-B/C at three positions in the ATP-binding pocket (L215, T217, and R220). Exploiting these differences, crystal structures of…”
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Molecular mechanisms of human IRE1 activation through dimerization and ligand binding by Joshi, Amar, Newbatt, Yvette, McAndrew, P Craig, Stubbs, Mark, Burke, Rosemary, Richards, Mark W, Bhatia, Chitra, Caldwell, John J, McHardy, Tatiana, Collins, Ian, Bayliss, Richard

“…IRE1 transduces the unfolded protein response by splicing XBP1 through its C-terminal cytoplasmic kinase-RNase region. IRE1 autophosphorylation is coupled to…”
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Structures of the Ultra-High-Affinity Protein–Protein Complexes of Pyocins S2 and AP41 and Their Cognate Immunity Proteins from Pseudomonas aeruginosa by Joshi, Amar, Grinter, Rhys, Josts, Inokentijs, Chen, Sabrina, Wojdyla, Justyna A., Lowe, Edward D., Kaminska, Renata, Sharp, Connor, McCaughey, Laura, Roszak, Aleksander W., Cogdell, Richard J., Byron, Olwyn, Walker, Daniel, Kleanthous, Colin

“…How ultra-high-affinity protein–protein interactions retain high specificity is still poorly understood. The interaction between colicin DNase domains and…”
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Investigating the protein and rna interactions of the polypyrimidine tract binding protein: high resolution structures with implications in the regulation of alternative splicing by Joshi, Amar

“…Alternative splicing produces multiple mRNAs from a single gene. It is a powerful mechanism used to amplify complexity of the metazoan proteome. The…”
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