Search Results - "Josephs, Jonathan L."

Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis by Bailey, Aaron O, Han, Guanghui, Phung, Wilson, Gazis, Paul, Sutton, Jennifer, Josephs, Jonathan L, Sandoval, Wendy

“…The preponderance and diversity of charge variants in therapeutic monoclonal antibodies has implications for antibody efficacy and degradation. Understanding…”
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Creation and comparison of MS/MS spectral libraries using quadrupole ion trap and triple-quadrupole mass spectrometers by Josephs, Jonathan L., Sanders, Mark

“…Searchable libraries of MS/MS spectra, obtained using liquid chromatography/tandem mass spectrometry (LC/MS/MS) with data‐dependent scan mode switching on both…”
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On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library. 3. Focus on ion trap and upfront CID by Oberacher, Herbert, Pitterl, Florian, Siapi, Eleni, Steele, Barry R., Letzel, Thomas, Grosse, Sylvia, Poschner, Bernhard, Tagliaro, Franco, Gottardo, Rossella, Chacko, Silvi A., Josephs, Jonathan L.

“…Mass spectral libraries represent versatile tools for the identification of small bioorganic molecules. Libraries based on electron impact spectra are rated…”
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Metabolite Generation via Microbial Biotransformations with Actinomycetes: Rapid Screening for Active Strains and Biosynthesis of Important Human Metabolites of Two Development-Stage Compounds, 5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101) and Dasatinib by Li, Wenying, Josephs, Jonathan L, Skiles, Gary L, Humphreys, W Griffith

“…The enzymes present in many microbial strains are capable of carrying out a variety of biotransformations when presented with drug-like molecules. Although the…”
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High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry by Shi, Rachel Liuqing, Dillon, Michael A, Compton, Philip D, Sawyer, William S, Thorup, John R, Kwong, Mandy, Chan, Pamela, Chiu, Cecilia P C, Li, Ran, Yadav, Rajbharan, Lee, Genee Y, Gober, Joshua G, Li, Zhiyu, ElSohly, Adel M, Ovacik, Ayse Meric, Koerber, James T, Spiess, Christoph, Josephs, Jonathan L, Tran, John C

“…Intact protein mass spectrometry (MS) coupled with liquid chromatography was applied to characterize the pharmacokinetics and stability profiles of therapeutic…”
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Strategy to Improve the Quantitative LC-MS Analysis of Molecular Ions Resistant to Gas-Phase Collision Induced Dissociation: Application to Disulfide-Rich Cyclic Peptides by Ciccimaro, Eugene, Ranasinghe, Asoka, D’Arienzo, Celia, Xu, Carrie, Onorato, Joelle, Drexler, Dieter M., Josephs, Jonathan L., Poss, Michael, Olah, Timothy

“…Due to observed collision induced dissociation (CID) fragmentation inefficiency, developing sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS)…”
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HRMS: current usage, future directions and the promise of integration with unified data streams suited to post-acquisition mining by Josephs, Jonathan L

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Quantitative estimation of circulating metabolites without synthetic standards by ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry in combination with UV correction by Yang, Yanou, Grubb, Mary F., Luk, Chiuwa E., Humphreys, W. Griffith, Josephs, Jonathan L.

“…An early assessment of metabolite exposure in preclinical species can provide quantitative estimation on possible active or toxic metabolites. Frequently,…”
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Bioactivation of 2‑(Alkylthio)-1,3,4-Thiadiazoles and 2‑(Alkylthio)-1,3-Benzothiazoles by Yang, Yanou, Qiu, Feng, Josephs, Jonathan L, Humphreys, W. Griffith, Shu, Yue-Zhong

“…Certain functional groups/structural motifs are known to generate chemically reactive metabolites that can covalently modify essential cellular macromolecules…”
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Novel MS solutions inspired by MIST by Ramanathan, Ragu, Josephs, Jonathan L, Jemal, Mohammed, Arnold, Mark, Humphreys, W Griffith

“…To improve patient safety and to help avoid costly late-stage failures, the pharmaceutical industry, along with the US FDA and International Committee on…”
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A semi-automated method for the integrated evaluation of half-life and metabolic soft spots of discovery compounds by Grubb, Mary F, Humphreys, William G, Josephs, Jonathan L

“…An integrated method that provides rates of both parent disappearance and metabolite formation was developed. Buspirone, mirtazapine and verapamil were used as…”
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An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates by Drexler, Dieter M, Belcastro, James V, Dickinson, Kenneth E, Edinger, Kurt J, Hnatyshyn, Serhiy Y, Josephs, Jonathan L, Langish, Robert A, McNaney, Colleen A, Santone, Kenneth S, Shipkova, Petia A, Tymiak, Adrienne A, Zvyaga, Tatyana A, Sanders, Mark

“…An automated high throughput process, termed the MetFast assay, is described to assess in vitro the general microsomal cytochrome P450 beta-nicotinamide…”
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Detection and Characterization of Fumonisin Mycotoxins by Liquid Chromatography/Electrospray Ionization Using Ion Trap and Triple Quadrupole Mass Spectrometry by Josephs, Jonathan L.

“…Electrospray ionization (ESI) high‐performance liquid chromatography/mass spectrometry using both ion trap and triple quadrupole mass spectrometers has been…”
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Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis by Bailey, Aaron O., Han, Guanghui, Phung, Wilson, Gazis, Paul, Sutton, Jennifer, Josephs, Jonathan L., Sandoval, Wendy

“…The preponderance and diversity of charge variants in therapeutic monoclonal antibodies has implications for antibody efficacy and degradation. Understanding…”
Get full text

Determination of Buprenorphine in Human Plasma by Gas Chromatography-Positive Ion Chemical Ionization Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry by Moody, David E., Laycock, John D., Spanbauer, Alan C., Crouch, Dennis J., Foltz, Rodger L., Josephs, Jonathan L., Amass, Leslie, Bickel, Warren K.

“…Buprenorphine is used for the management of pain and has been advocated for the treatment of opioid addiction. Therapeutic doses result in low plasma…”
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