Search Results - "Joseph Tector, A."

Portal Vein Thrombosis Is a Risk Factor for Poor Early Outcomes After Liver Transplantation: Analysis of Risk Factors and Outcomes for Portal Vein Thrombosis in Waitlisted Patients by Ghabril, Marwan, Agarwal, Saurabh, Lacerda, Marco, Chalasani, Naga, Kwo, Paul, Tector, A Joseph

“…BACKGROUNDPortal vein thrombosis (PVT) is common in patients with cirrhosis, but the risk factors associated with PVT and its impact on outcomes following…”
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Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs by Martens, Gregory R, Reyes, Luz M, Butler, James R, Ladowski, Joseph M, Estrada, Jose L, Sidner, Richard A, Eckhoff, Devin E, Tector, Matt, Tector, A Joseph

“…BACKGROUNDAntipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan…”
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Stereotactic Body Radiotherapy for Primary Hepatocellular Carcinoma by Andolino, David L., M.D, Johnson, Cynthia S., M.S, Maluccio, Mary, M.D, Kwo, Paul, M.D, Tector, A. Joseph, M.D, Zook, Jennifer, M.D, Johnstone, Peter A.S., M.D, Cardenes, Higinia R., M.D., Ph.D

“…Purpose To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of primary hepatocellular carcinoma (HCC). Methods and…”
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Creating class I MHC-null pigs using guide RNA and the Cas9 endonuclease by Reyes, Luz M, Estrada, Jose L, Wang, Zheng Yu, Blosser, Rachel J, Smith, Rashod F, Sidner, Richard A, Paris, Leela L, Blankenship, Ross L, Ray, Caitlin N, Miner, Aaron C, Tector, Matthew, Tector, A Joseph

“…Pigs are emerging as important large animal models for biomedical research, and they may represent a source of organs for xenotransplantation. The MHC is…”
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Evaluation of response after stereotactic body radiotherapy for hepatocellular carcinoma by Price, Tracy R., Perkins, Susan M., Sandrasegaran, Kumar, Henderson, Mark A., Maluccio, Mary A., Zook, Jennifer E., Tector, A. Joseph, Vianna, Rodrigo M., Johnstone, Peter A.S., Cardenes, Higinia R.

“…BACKGROUND: Hepatocellular carcinoma (HCC) is increasing in incidence due to hepatitis C. Stereotactic body radiotherapy (SBRT) is a noninvasive, effective…”
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Multivisceral Transplantation for Diffuse Portomesenteric Thrombosis by VIANNA, Rodrigo M, MANGUS, Richard S, KUBAL, Chandrashekhar, FRIDELL, Jonathan A, BEDUSCHI, Thiago, TECTOR, A. Joseph

“…To evaluate the clinical outcomes of multivisceral transplantation (MVT) in the setting of diffuse thrombosis of the portomesenteric venous system. Liver…”
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Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model by Higginbotham, Laura, Mathews, Dave, Breeden, Cynthia A., Song, Mingqing, Farris III, Alton Brad, Larsen, Christian P., Ford, Mandy L., Lutz, Andrew J., Tector, Matthew, Newell, Kenneth A., Tector, A. Joseph, Adams, Andrew B.

“…Xenotransplantation has the potential to alleviate the organ shortage that prevents many patients with end‐stage renal disease from enjoying the benefits of…”
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The need for xenotransplantation as a source of organs and cells for clinical transplantation by Ekser, Burcin, Cooper, David K.C, Tector, A. Joseph

“…Abstract The limited availability of deceased human organs and cells for the purposes of clinical transplantation remains critical worldwide. Despite the…”
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Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins by Ladowski, Joseph M, Martens, Gregory R, Reyes, Luz M, Wang, Zheng-Yu, Eckhoff, Devin E, Hauptfeld-Dolejsek, Vera, Tector, Matt, Tector, A Joseph

“…Genetically engineered pig organs could provide transplants to all patients with end-stage organ failure, but Ab-mediated rejection remains an issue. This…”
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CRISPR genome-editing: A medical revolution by Butler, James R., MD, Tector, A. Joseph, MD, PhD

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Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection by Li, Ping, Estrada, Jose L., Burlak, Christopher, Montgomery, Jessica, Butler, James R., Santos, Rafael M., Wang, Zheng-Yu, Paris, Leela L., Blankenship, Ross L., Downey, Susan M., Tector, Matthew, Tector, A. Joseph

“…Background Manipulating the pig genome to increase compatibility with human biology may facilitate the clinical application of xenotransplantation. Genetic…”
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Eliminating Xenoantigen Expression on Swine RBC by Wang, Zheng-Yu, Martens, Gregory R., Blankenship, Ross L., Sidner, Richard A., Li, Ping, Estrada, Jose L., Tector, Matthew, Tector, A. Joseph

“…BACKGROUNDThe rapidly improving tools of genetic engineering may make it possible to overcome the humoral immune barrier that prevents xenotransplantation. We…”
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Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers by Butler, James Russell, Paris, Leela L, Blankenship, Ross L, Sidner, Richard A, Martens, Gregory R, Ladowski, Joseph M, Li, Ping, Estrada, Jose L, Tector, Matthew, Tector, A Joseph

“…A profound thrombocytopenia limits hepatic xenotransplantation in the pig-to-primate model. Porcine livers also have shown the ability to phagocytose human…”
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Role of cardiac catheterization and percutaneous coronary intervention in the preoperative assessment and management of patients before orthotopic liver transplantation by Maddur, Haripriya, Bourdillon, Patrick D., Liangpunsakul, Suthat, Joseph Tector, A., Fridell, Jonathan A., Ghabril, Marwan, Lacerda, Marco A., Bourdillon, Charlotte, Shen, Changyu, Kwo, Paul Y.

“…Limited data regarding the optimal risk assessment strategy for evaluating candidates for orthotopic liver transplantation (OLT) exist. Our center has adopted…”
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Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival by TECTOR, A. Joseph, MANGUS, Richard S, CHESTOVICH, Paul, VIANNA, Rodrigo, FRIDELL, Jonathan A, MILGROM, Martin L, SANDERS, Carrie, KWO, Paul Y

“…The use of extended criteria donors (ECDs) could minimize shortage of suitable donor livers for transplantation. In 3 years, the aggressive use of ECD livers…”
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Xenotransplantation in Humans: A Reality Check by Tector, A Joseph

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Immunogenicity of Renal Microvascular Endothelial Cells From Genetically Modified Pigs by Wang, Zheng-Yu, Li, Ping, Butler, James R, Blankenship, Ross L, Downey, Susan M, Montgomery, Jessica B, Nagai, Shunji, Estrada, Jose L, Tector, Matthew F, Tector, A Joseph

“…Disrupting the porcine GGTA1 and CMAH genes [double knockout (DKO)] that produce the gal-α(1,3)-gal and N-glycolylneuraminic acid xenoantigens reduces human…”
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Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables by Sher, Linda S., Levi, David M., Wecsler, Julie S., Lo, Mary, Petrovic, Lydia M., Groshen, Susan, Ji, Lingyun, Uso, Teresa Diago, Tector, A. Joseph, Hamilton, Ann S., Marsh, J. Wallis, Schwartz, Myron E.

“…Background Patient selection for liver transplantation for metastatic neuroendocrine tumors remains a topic of debate. There is no established MELD exception,…”
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Erythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates by Wang, Zheng-Yu, Burlak, Christopher, Estrada, Jose L., Li, Ping, Tector, Matthew F., Tector, A. Joseph

“…Background Pig erythrocytes are potentially useful to solve the worldwide shortage of human blood for transfusion. Domestic pig erythrocytes, however, express…”
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Pig Liver Xenotransplantation as a Bridge to Allotransplantation: Which Patients Might Benefit? by EKSER, Burcin, GRIDELLI, Bruno, TECTOR, A. Joseph, COOPER, David K. C

“…Acute liver failure is a potentially devastating clinical syndrome that, without liver transplantation (Tx), is associated with high mortality. Rapid…”
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