Search Results - "Joseph Silburt"

MORPHIOUS: an unsupervised machine learning workflow to detect the activation of microglia and astrocytes by Silburt, Joseph, Aubert, Isabelle

“…In conditions of brain injury and degeneration, defining microglial and astrocytic activation using cellular markers alone remains a challenging task. We…”
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The human brain endothelial barrier: transcytosis of AAV9, transduction by AAV2 by Weber‐Adrian, Danielle, Heinen, Stefan, Silburt, Joseph, Noroozian, Zeinab, Aubert, Isabelle

“…Read the highlighted article ‘Trafficking of adeno‐associated virus vectors across a model of the blood–brain barrier; a comparative study of transcytosis and…”
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Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis by Kofoed, Rikke Hahn, Heinen, Stefan, Silburt, Joseph, Dubey, Sonam, Dibia, Chinaza Lilian, Maes, Miriam, Simpson, Elizabeth M., Hynynen, Kullervo, Aubert, Isabelle

“…Efficient disease-modifying treatments for Alzheimer disease, the most common form of dementia, have yet to be established. Gene therapy has the potential to…”
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Disrupting the blood–brain barrier with focused ultrasound: Perspectives on inflammation and regeneration by Silburt, Joseph, Lipsman, Nir, Aubert, Isabelle

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Glutamate Induces Blood-Brain Barrier Permeability through Activation of N-Methyl-D-Aspartate Receptors by Xhima, Kristiana, Weber-Adrian, Danielle, Silburt, Joseph

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The Glial Response to Focused Ultrasound-Mediated Permeabilization of the Blood-Brain Barrier: Evaluating the Potential Contribution of Microglia and Astrocytes to Pathology and Regeneration by Silburt, Joseph

“…Focused ultrasound in the presence of intravenous microbubbles (FUS) facilitates the non-invasive temporary permeabilization of the blood-brain barrier (BBB)…”
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Median Meld at Transplant Minus 3 Reduces the Mortality of Non-Hepatocellular Carcinoma Patients on the Liver Transplant Waitlist by Pouramin, Panthea, Allen, Susan E., Silburt, Joseph L., Gala-Lopez, Boris L.

“…Liver transplants (LTs) are prioritized by mortality risk, which is estimated by MELD scores. Since hepatocellular carcinoma (HCC) patients present with lower…”
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Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery by Weber-Adrian, Danielle, Kofoed, Rikke Hahn, Silburt, Joseph, Noroozian, Zeinab, Shah, Kairavi, Burgess, Alison, Rideout, Shawna, Kügler, Sebastian, Hynynen, Kullervo, Aubert, Isabelle

“…Non-surgical gene delivery to the brain can be achieved following intravenous injection of viral vectors coupled with transcranial MRI-guided focused…”
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The human brain endothelial barrier: transcytosis of AAV9, transduction by AAV2: An Editorial Highlight for 'Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells' by Weber-Adrian, Danielle, Heinen, Stefan, Silburt, Joseph, Noroozian, Zeinab, Aubert, Isabelle

“…Read the highlighted article 'Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and…”
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Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease by Weber-Adrian, Danielle, Kofoed, Rikke Hahn, Chan, Josephine Wing Yee, Silburt, Joseph, Noroozian, Zeinab, Kügler, Sebastian, Hynynen, Kullervo, Aubert, Isabelle

“…Gene therapy can be designed to efficiently counter pathological features characteristic of neurodegenerative disorders. Here, we took advantage of the glial…”
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A Blinded Comparison of Three Generative Artificial Intelligence Chatbots for Orthopaedic Surgery Therapeutic Questions by Arora, Vikram, Silburt, Joseph, Phillips, Mark, Khan, Moin, Petrisor, Brad, Chaudhry, Harman, Mundi, Raman, Bhandari, Mohit

“…Objective To compare the quality of responses from three chatbots (ChatGPT, Bing Chat, and AskOE) across various orthopaedic surgery therapeutic treatment…”
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NEURON-SPECIFIC TRANSGENE DELIVERY TO THE BRAIN USING MRI-GUIDED FOCUSED ULTRASOUND by Weber-Adrian, Danielle, Noroozian, Zeinab, Silburt, Joseph, Shah, Kairavi, Burgess, Alison, Kügler, Sebastian, Hynynen, Kullervo, Aubert, Isabelle

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P2‐247: Neuron‐Specific Transgene Delivery to the Brain using MRI‐Guided Focused Ultrasound by Weber-Adrian, Danielle, Noroozian, Zeinab, Silburt, Joseph, Shah, Kairavi, Burgess, Alison, Kügler, Sebastian, Hynynen, Kullervo, Aubert, Isabelle

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Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1 2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery by Danielle Weber-Adrian, Rikke Hahn Kofoed, Joseph Silburt, Zeinab Noroozian, Kairavi Shah, Alison Burgess, Shawna Rideout, Sebastian Kügler, Kullervo Hynynen, Isabelle Aubert

“…Abstract Non-surgical gene delivery to the brain can be achieved following intravenous injection of viral vectors coupled with transcranial MRI-guided focused…”
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