Search Results - "Joseph El Khoury"

Microglia in neurodegeneration by Hickman, Suzanne, Izzy, Saef, Sen, Pritha, Morsett, Liza, El Khoury, Joseph

“…The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a century…”
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Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift by Jassam, Yasir N., Izzy, Saef, Whalen, Michael, McGavern, Dorian B., El Khoury, Joseph

“…Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a considerable socioeconomic burden. Heterogeneity of pathoanatomical…”
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TREM2 and the neuroimmunology of Alzheimer's disease by Hickman, Suzanne E., El Khoury, Joseph

“…Late-onset Alzheimer's disease (AD) is a sporadic disorder with increasing prevalence in aging. The ɛ4 allele of Apolipoprotein E(ApoEɛ4) was the only known…”
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The microglial sensome revealed by direct RNA sequencing by Hickman, Suzanne E, Kingery, Nathan D, Ohsumi, Toshiro K, Borowsky, Mark L, Wang, Li-chong, Means, Terry K, El Khoury, Joseph

“…In this Resource study, the authors used Direct RNA Sequencing (DRS) to quantitatively examine the transcriptional profile of microglia, focusing specifically…”
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TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease by Griciuc, Ana, Patel, Shaun, Federico, Anthony N., Choi, Se Hoon, Innes, Brendan J., Oram, Mary K., Cereghetti, Gea, McGinty, Danielle, Anselmo, Anthony, Sadreyev, Ruslan I., Hickman, Suzanne E., El Khoury, Joseph, Colonna, Marco, Tanzi, Rudolph E.

“…The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer’s disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We…”
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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer by Halle, Annett, Khoury, Joseph El, Lacy-Hulbert, Adam, Stewart, Cameron R, Frazier, William A, Rayner, Katey J, Boyer, Laurent, Moore, Kathryn J, van Gils, Janine M, Zhong, Ruiqin, Stuart, Lynda M, Deng, Jiusheng, Golenbock, Douglas T, Wilkinson, Kim

“…The molecular mechanisms behind recognition of altered self remain unclear. Moore and co-workers show that oxidized low-density lipoprotein (LDL) and β-amyloid…”
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Standardizing scavenger receptor nomenclature by Prabhudas, Mercy, Bowdish, Dawn, Drickamer, Kurt, Febbraio, Maria, Herz, Joachim, Kobzik, Lester, Krieger, Monty, Loike, John, Means, Terry K, Moestrup, Soren K, Post, Steven, Sawamura, Tatsuya, Silverstein, Samuel, Wang, Xiang-Yang, El Khoury, Joseph

“…Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These…”
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Mechanisms of microglia accumulation in Alzheimer’s disease: therapeutic implications by Khoury, Joseph El, Luster, Andrew D

“…In Alzheimer’s disease (AD), and other conditions affecting integrity of the blood–brain barrier, microglia can originate in the bone marrow, migrate into the…”
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Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria by Campanella, Gabriele S.V, Tager, Andrew M, El Khoury, Joseph K, Thomas, Seddon Y, Abrazinski, Tabitha A, Manice, Lindsay A, Colvin, Richard A, Luster, Andrew D

“…Cerebral malaria is a significant cause of global mortality, causing an estimated two million deaths per year, mainly in children. The pathogenesis of this…”
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The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity by Ramirez-Ortiz, Zaida G, Pendergraft, William F, Prasad, Amit, Byrne, Michael H, Iram, Tal, Blanchette, Christopher J, Luster, Andrew D, Hacohen, Nir, Khoury, Joseph El, Means, Terry K

“…Failure to clear apoptotic cells can lead to autoinflammatory disease. Means and colleagues demonstrate that the receptor SCARF1 recognizes C1q-bound apoptotic…”
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Comparative Analysis Identifies Similarities between the Human and Murine Microglial Sensomes by Abels, Erik R, Nieland, Lisa, Hickman, Suzanne, Broekman, Marike L D, El Khoury, Joseph, Maas, Sybren L N

“…One of the essential functions of microglia is to continuously sense changes in their environment and adapt to those changes. For this purpose, they use a set…”
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Case 11-2020: A 37-Year-Old Man with Facial Droop, Dysarthria, and Kidney Failure by Berns, Jeffrey S, Rapalino, Otto, Fenves, Andrew Z, El Khoury, Joseph B, Klepeis, Veronica E, Anahtar, Melis N

“…A 37-year-old man with a history of injection-drug use presented with a facial droop, dysarthria, and kidney failure. The creatinine level was 16.1 mg per…”
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Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease by Hickman, Suzanne E, El Khoury, Joseph

“…Alzheimer's disease (AD) is associated with a significant neuroinflammatory component. Mononuclear phagocytes including monocytes and microglia are the…”
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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity by Ramirez-Ortiz, Zaida G, Prasad, Amit, Griffith, Jason W, Pendergraft, William F, Cowley, Glenn S, Root, David E, Tai, Melissa, Luster, Andrew D, El Khoury, Joseph, Hacohen, Nir, Means, Terry K

“…Fine-tuning of TLR7 signaling modulates innate inflammatory responses. Means and colleagues identify the receptor TREML4 as an essential positive regulator of…”
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Repetitive head injury in adolescent mice: A role for vascular inflammation by Wu, Limin, Chung, Joon Y, Saith, Shivani, Tozzi, Lorenzo, Buckley, Erin M, Sanders, Bharat, Franceschini, Maria A, Lule, Sevda, Izzy, Saef, Lok, Josephine, Edmiston, William J, McAllister, Lauren M, Mebane, Sloane, Jin, Gina, Lu, Jiaxi, Sherwood, John S, Willwerth, Sarah, Hickman, Suzanne, Khoury, Joseph El, Lo, Eng H, Kaplan, David, Whalen, Michael J

“…Repetitive mild traumatic brain injury during adolescence can induce neurological dysfunction through undefined mechanisms. Interleukin-1 (IL-1) contributes to…”
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Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 by Means, Terry K, Mylonakis, Eleftherios, Tampakakis, Emmanouil, Colvin, Richard A, Seung, Edward, Puckett, Lindsay, Tai, Melissa F, Stewart, Cameron R, Pukkila-Worley, Read, Hickman, Suzanne E, Moore, Kathryn J, Calderwood, Stephen B, Hacohen, Nir, Luster, Andrew D, El Khoury, Joseph

“…Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3,…”
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Clinical utility of ICD‐11 diagnostic guidelines for high‐burden mental disorders: results from mental health settings in 13 countries by Reed, Geoffrey M., Keeley, Jared W., Rebello, Tahilia J., First, Michael B., Gureje, Oye, Ayuso‐Mateos, José Luis, Kanba, Shigenobu, Khoury, Brigitte, Kogan, Cary S., Krasnov, Valery N., Maj, Mario, Jesus Mari, Jair, Sharan, Pratap, Stein, Dan J., Zhao, Min, Akiyama, Tsuyoshi, Andrews, Howard F., Asevedo, Elson, Cheour, Majda, Domínguez‐Martínez, Tecelli, El‐Khoury, Joseph, Fiorillo, Andrea, Grenier, Jean, Gupta, Nitin, Kola, Lola, Kulygina, Maya, Leal‐Leturia, Itziar, Luciano, Mario, Lusu, Bulumko, Martínez‐López, J. Nicolás I., Matsumoto, Chihiro, Odunleye, Mayokun, Onofa, Lucky Umukoro, Paterniti, Sabrina, Purnima, Shivani, Robles, Rebeca, Sahu, Manoj K., Sibeko, Goodman, Zhong, Na, Gaebel, Wolfgang, Lovell, Anne M., Maruta, Toshimasa, Pike, Kathleen M., Roberts, Michael C., Medina‐Mora, María Elena

“…In this paper we report the clinical utility of the diagnostic guidelines for ICD‐11 mental, behavioural and neurodevelopmental disorders as assessed by 339…”
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Repetitive Traumatic Brain Injury Causes Neuroinflammation before Tau Pathology in Adolescent P301S Mice by Izzy, Saef, Brown-Whalen, Alexander, Yahya, Taha, Sarro-Schwartz, Aliyah, Jin, Gina, Chung, Joon Yong, Lule, Sevda, Morsett, Liza M, Alquraini, Ali, Wu, Limin, Hickman, Suzanne E, Whalen, Michael J, El Khoury, Joseph

“…Repetitive closed head injury (rCHI) is commonly encountered in young athletes engaged in contact and collision sports. Traumatic brain injury (TBI) including…”
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Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis by Wu, Limin, Chung, Joon Yong, Cao, Tian, Jin, Gina, Edmiston, William J., Hickman, Suzanne, Levy, Emily S., Whalen, Jordyn A., Abrams, Eliza Sophie LaRovere, Degterev, Alexei, Lo, Eng H., Tozzi, Lorenzo, Kaplan, David L., El Khoury, Joseph, Whalen, Michael J.

“…Traumatic brain injury (TBI) is a leading cause of death and disability with no specific effective therapy, in part because disease driving mechanisms remain…”
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Scavenger receptors by Alquraini, Ali, El Khoury, Joseph

“…Scavenger receptors (SRs) are a large family of cell-surface receptors that are diverse in their structure and biological function and are divided into…”
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