Search Results - "Joseph, Suresh"

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360 by Paillard, Melanie, Csordás, György, Huang, Kai-Ting, Várnai, Peter, Joseph, Suresh K., Hajnóczky, György

“…Proper control of the mitochondrial Ca2+ uniporter’s pore (MCU) is required to allow Ca2+-dependent activation of oxidative metabolism and to avoid…”
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Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER by Booth, David M., Várnai, Péter, Joseph, Suresh K., Hajnóczky, György

“…The emerging role of mitochondria as signaling organelles raises the question of whether individual mitochondria can initiate heterotypic communication with…”
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IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer by Bartok, Adam, Weaver, David, Golenár, Tünde, Nichtova, Zuzana, Katona, Máté, Bánsághi, Száva, Alzayady, Kamil J., Thomas, V. Kaye, Ando, Hideaki, Mikoshiba, Katsuhiko, Joseph, Suresh K., Yule, David I., Csordás, György, Hajnóczky, György

“…Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP 3 receptors (IP3R) and the mitochondrial calcium…”
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Multi-classifier and meta-heuristic based cache pollution attacks and interest flooding attacks detection and mitigation model for named data networking by R., Buvanesvari, Joseph K, Suresh

“…This study's main goal is to provide a novel assault detection model with two phases. The features such node, distribution, pattern, frequency, and run time…”
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Energy and spectrum aware unequal clustering with deep learning based primary user classification in cognitive radio sensor networks by Stephan, Thompson, Al-Turjman, Fadi, K, Suresh Joseph, Balusamy, Balamurugan

“…The problem of energy efficiency in cognitive radio sensor networks (CRSN) is mainly caused by the limited energy of sensor nodes and other channel-related…”
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Isoform- and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP3) Receptors by Reactive Oxygen Species by Bánsághi, Száva, Golenár, Tünde, Madesh, Muniswamy, Csordás, György, RamachandraRao, Satish, Sharma, Kumar, Yule, David I., Joseph, Suresh K., Hajnóczky, György

“…Reactive oxygen species (ROS) stimulate cytoplasmic [Ca2+] ([Ca2+]c) signaling, but the exact role of the IP3 receptors (IP3R) in this process remains unclear…”
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Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity by Dong, Zhiwei, Shanmughapriya, Santhanam, Tomar, Dhanendra, Siddiqui, Naveed, Lynch, Solomon, Nemani, Neeharika, Breves, Sarah L., Zhang, Xueqian, Tripathi, Aparna, Palaniappan, Palaniappan, Riitano, Massimo F., Worth, Alison M., Seelam, Ajay, Carvalho, Edmund, Subbiah, Ramasamy, Jaña, Fabián, Soboloff, Jonathan, Peng, Yizhi, Cheung, Joseph Y., Joseph, Suresh K., Caplan, Jeffrey, Rajan, Sudarsan, Stathopulos, Peter B., Madesh, Muniswamy

“…Ca2+ dynamics and oxidative signaling are fundamental mechanisms for mitochondrial bioenergetics and cell function. The MCU complex is the major pathway by…”
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Adaptive Load Balancing Schema for efficient data dissemination in Vehicular Ad-Hoc Network VANET by Vijayakumar, V, Suresh Joseph, K

“…•Adaptive Load Balancing Schema for data dissemination has been developed for V2I communication model.•Expected Transmission Time will be calculated based on…”
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Redox regulation of ER and mitochondrial Ca2+ signaling in cell survival and death by Joseph, Suresh K., Booth, David M., Young, Michael P., Hajnóczky, György

“…[Display omitted] •Methods for the measurement of IP3 receptor redox state are described.•Findings regarding the role of cytosolic and luminal IP3R thiols are…”
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Role of Inositol Trisphosphate Receptors in Autophagy in DT40 Cells by Khan, M. Tariq, Joseph, Suresh K.

“…Previous studies have shown that small interfering RNA knockdown and pharmacological inhibition of inositol 1,4,5-trisphosphate receptors (IP3Rs) stimulate…”
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Metabolic adaptation to the chronic loss of Ca2+ signaling induced by KO of IP3 receptors or the mitochondrial Ca2+ uniporter by Young, Michael P., Schug, Zachary T., Booth, David M., Yule, David I., Mikoshiba, Katsuhiko, Hajnόczky, Gyӧrgy, Joseph, Suresh K.

“…Calcium signaling is essential for regulating many biological processes. Endoplasmic reticulum inositol trisphosphate receptors (IP3Rs) and the mitochondrial…”
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Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells by Joseph, Suresh K., Young, Michael P., Alzayady, Kamil, Yule, David I., Ali, Mehboob, Booth, David M., Hajnóczky, György

“…A sensitization of inositol 1,4,5-trisphosphate receptor (IP3R)–mediated Ca2+ release is associated with oxidative stress in multiple cell types. These effects…”
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Particle Swarm Optimization-Based Energy Efficient Channel Assignment Technique for Clustered Cognitive Radio Sensor Networks by Stephan, Thompson, Suresh Joseph, K

“…Abstract In a clustered cognitive radio sensor network (CRSN), the available free channels should be considered during cluster head (CH) election. Energy…”
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IP₃ receptors in cell survival and apoptosis: Ca²⁺ release and beyond by Joseph, Suresh K, Hajnóczky, György

“…Inositol 1,4,5-trisphosphate receptors (IP₃Rs) serve to discharge Ca²⁺ from ER stores in response to agonist stimulation. The present review summarizes the…”
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Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors by Arige, Vikas, Terry, Lara E, Wagner, 2nd, Larry E, Malik, Sundeep, Baker, Mariah R, Fan, Guizhen, Joseph, Suresh K, Serysheva, Irina I, Yule, David I

“…Inositol 1,4,5-trisphosphate receptors (IP Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca )…”
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Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle by De La Fuente, Sergio, Fernandez-Sanz, Celia, Vail, Caitlin, Agra, Elorm J., Holmstrom, Kira, Sun, Junhui, Mishra, Jyotsna, Williams, Dewight, Finkel, Toren, Murphy, Elizabeth, Joseph, Suresh K., Sheu, Shey-Shing, Csordás, György

“…Control of myocardial energetics by Ca2+ signal propagation to the mitochondrial matrix includes local Ca2+ delivery from sarcoplasmic reticulum (SR) ryanodine…”
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An Improved Boykov's Graph Cut-based Segmentation Technique for the Efficient Detection of Cervical Cancer by Devi, Anousouya, Ezhilarasie, R, Joseph, Suresh, Kotecha, Ketan, Abraham, Ajith, Vairavasundaram, Subramaniyaswamy

“…The accurate and reliable derivation of the pap smear cell, which contains cytoplasm and nucleus regions, depends on the segmentation process employed in the…”
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Subcellular ROS imaging methods: Relevance for the study of calcium signaling by Booth, David M, Joseph, Suresh K, Hajnóczky, György

“…Graphical abstract…”
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MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca 2+ uniporter channel by Tomar, Dhanendra, Thomas, Manfred, Garbincius, Joanne F, Kolmetzky, Devin W, Salik, Oniel, Jadiya, Pooja, Joseph, Suresh K, Carpenter, April C, Hajnóczky, György, Elrod, John W

“…MICU1 is a calcium (Ca )-binding protein that regulates the mitochondrial Ca uniporter channel complex (mtCU) and mitochondrial Ca uptake. knockout mice…”
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S-glutathionylation activates STIM1 and alters mitochondrial homeostasis by Hawkins, Brian J, Irrinki, Krishna M, Mallilankaraman, Karthik, Lien, Yu-Chin, Wang, Youjun, Bhanumathy, Cunnigaiper D, Subbiah, Ramasamy, Ritchie, Michael F, Soboloff, Jonathan, Baba, Yoshihiro, Kurosaki, Tomohiro, Joseph, Suresh K, Gill, Donald L, Madesh, Muniswamy

“…Oxidant stress influences many cellular processes, including cell growth, differentiation, and cell death. A well-recognized link between these processes and…”
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