Search Results - "Joseph, R. P."

Measurement of Elastic Modulus of Collagen Type I Single Fiber by Dutov, Pavel, Antipova, Olga, Varma, Sameer, Orgel, Joseph P R O, Schieber, Jay D

“…Collagen fibers are the main components of the extra cellular matrix and the primary contributors to the mechanical properties of tissues. Here we report a…”
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Microfibrillar Structure of Type I Collagen in situ by Orgel, Joseph P. R. O., Irving, Thomas C., Miller, Andrew, Wess, Tim J.

“…The fibrous collagens are ubiquitous in animals and form the structural basis of all mammalian connective tissues, including those of the heart, vasculature,…”
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Intermolecular channels direct crystal orientation in mineralized collagen by Xu, YiFei, Nudelman, Fabio, Eren, E. Deniz, Wirix, Maarten J. M., Cantaert, Bram, Nijhuis, Wouter H., Hermida-Merino, Daniel, Portale, Giuseppe, Bomans, Paul H. H., Ottmann, Christian, Friedrich, Heiner, Bras, Wim, Akiva, Anat, Orgel, Joseph P. R. O., Meldrum, Fiona C., Sommerdijk, Nico

“…The mineralized collagen fibril is the basic building block of bone, and is commonly pictured as a parallel array of ultrathin carbonated hydroxyapatite (HAp)…”
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Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding by Orgel, Joseph P R O, Eid, Aya, Antipova, Olga, Bella, Jordi, Scott, John E

“…Decorin is the archetypal small leucine rich repeat proteoglycan of the vertebrate extracellular matrix (ECM). With its glycosaminoglycuronan chain, it is…”
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Contrasting Local and Macroscopic Effects of Collagen Hydroxylation by Varma, Sameer, Orgel, Joseph P. R. O., Schieber, Jay D.

“…Collagen is heavily hydroxylated. Experiments show that proline hydroxylation is important to triple helix (monomer) stability, fibril assembly, and…”
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Molecular Tissue Responses to Mechanical Loading by Orgel, Joseph P R O

“…The intention of this special edition is to highlight the benefits of a holistic approach to computational and experimental approaches in the context of aiding…”
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Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis by Perumal, Shiamalee, Antipova, Olga, Orgel, Joseph P.R.O

“…We describe the molecular structure of the collagen fibril and how it affects collagen proteolysis or "collagenolysis." The fibril-forming collagens are major…”
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Variation in the helical structure of native collagen by Orgel, Joseph P R O, Persikov, Anton V, Antipova, Olga

“…The structure of collagen has been a matter of curiosity, investigation, and debate for the better part of a century. There has been a particularly productive…”
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Ultrastructural Location and Interactions of the Immunoglobulin Receptor Binding Sequence within Fibrillar Type I Collagen by Zhu, Jie, Madhurapantula, Rama S, Kalyanasundaram, Aruna, Sabharwal, Tanya, Antipova, Olga, Bishnoi, Sandra W, Orgel, Joseph P R O

“…Collagen type I is a major constituent of animal bodies. It is found in large quantities in tendon, bone, skin, cartilage, blood vessels, bronchi, and the lung…”
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Functional Grading of a Transversely Isotropic Hyperelastic Model with Applications in Modeling Tricuspid and Mitral Valve Transition Regions by Roy, Rajarshi, Warren, Jr, Eric, Xu, Yaoyao, Yow, Caleb, Madhurapantula, Rama S, Orgel, Joseph P R O, Lister, Kevin

“…Surgical simulators and injury-prediction human models require a combination of representative tissue geometry and accurate tissue material properties to…”
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Evidence for Novel β-Sheet Structures in Iowa Mutant β-Amyloid Fibrils by Tycko, Robert, Sciarretta, Kimberly L, Orgel, Joseph P. R. O, Meredith, Stephen C

“…Asp23-to-Asn mutation within the coding sequence of β-amyloid, called the Iowa mutation, is associated with early onset, familial Alzheimer’s disease and…”
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Molecular and ultrastructural studies of a fibrillar collagen from octocoral (Cnidaria) by Orgel, Joseph P R O, Sella, Ido, Madhurapantula, Rama S, Antipova, Olga, Mandelberg, Yael, Kashman, Yoel, Benayahu, Dafna, Benayahu, Yehuda

“…We report here the biochemical, molecular and ultrastructural features of a unique organization of fibrillar collagen extracted from the octocoral Collagen,…”
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Diversity and geographic distribution of soil streptomycetes with antagonistic potential against actinomycetoma-causing Streptomyces sudanensis in Sudan and South Sudan by Hamid, Mohamed E, Reitz, Thomas, Joseph, Martin R P, Hommel, Kerstin, Mahgoub, Adil, Elhassan, Mogahid M, Buscot, François, Tarkka, Mika

“…Production of antibiotics to inhibit competitors affects soil microbial community composition and contributes to disease suppression. In this work, we…”
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Large Deformation and Strain Gradient Fracture Analysis of Double Cantilever Beams with Piezoelectric Effect by Joseph, R. P, Wang, B. L, Samali, B

“…AbstractThis paper examines the size-dependent fracture of a piezoelectric double cantilever beam (DCB) specimen based on large deformation–strain gradient…”
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Non-enzymatic decomposition of collagen fibers by a biglycan antibody and a plausible mechanism for rheumatoid arthritis by Antipova, Olga, Orgel, Joseph P R O

“…Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory and destructive joint disorder that affects tens of millions of people worldwide. Normal…”
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In Situ D-periodic Molecular Structure of Type II Collagen by Antipova, Olga, Orgel, Joseph P.R.O.

“…Collagens are essential components of extracellular matrices in multicellular animals. Fibrillar type II collagen is the most prominent component of articular…”
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Dinosaur peptides suggest mechanisms of protein survival by San Antonio, James D, Schweitzer, Mary H, Jensen, Shane T, Kalluri, Raghu, Buckley, Michael, Orgel, Joseph P R O

“…Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril…”
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A structural prospective for collagen receptors such as DDR and their binding of the collagen fibril by Orgel, Joseph P.R.O., Madhurapantula, Rama S.

“…The structure of the collagen fibril surface directly effects and possibly assists the management of collagen receptor interactions. An important class of…”
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Multidrug-Resistant Acinetobacter baumannii: An Emerging Health Threat in Aseer Region, Kingdom of Saudi Arabia by Hamid, Mohamed E., Assiry, Mohammed M., Joseph, Martin R. P., Almaghrabi, Mohammed K.

“…Objective. The study aims to determine the prevalence of multidrug-resistant A. baumannii in Aseer Region, Kingdom of Saudi Arabia. Methods. This study…”
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Helix-Turn-Helix Peptides That Form α-Helical Fibrils:  Turn Sequences Drive Fibril Structure by Lazar, Kristi L, Miller-Auer, Hélène, Getz, Godfrey S, Orgel, Joseph P. R. O, Meredith, Stephen C

“…Models of apolipoprotein A-I (apo A-I), the main protein of high-density lipoprotein, predict that it contains 10 amphiphilic, α-helical segments connected by…”
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