Search Results - "Joseph, Mary K"

Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines by Tahir, Stephen K, Wass, John, Joseph, Mary K, Devanarayan, Viswanath, Hessler, Paul, Zhang, Haichao, Elmore, Steve W, Kroeger, Paul E, Tse, Christin, Rosenberg, Saul H, Anderson, Mark G

“…ABT-263 inhibits the antiapoptotic proteins Bcl-2, Bcl-x(L), and Bcl-w and has single-agent efficacy in numerous small cell lung carcinoma (SCLC) and…”
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A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo by SHOEMAKER, Alex R, OLEKSIJEW, Anatol, MARSH, Kennan, MCCLELLAN, William, NELLANS, Hugh, NG, Shichung, NIMMER, Paul, O'CONNOR, Jacqueline M, OLTERSDORF, Tilman, WEIGUO QING, WANG SHEN, STAVROPOULOS, Jason, BAUCH, Joy, TAHIR, Stephen K, BAOLE WANG, WARNER, Robert, HAICHAO ZHANG, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, BELLI, Barbara A, BORRE, Tony, BRUNCKO, Milan, DECKWIRTH, Thomas, FROST, David J, JARVIS, Ken, JOSEPH, Mary K

“…Inhibition of the prosurvival members of the Bcl-2 family of proteins represents an attractive strategy for the treatment of cancer. We have previously…”
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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis by Petros, Andrew M, Dinges, Jurgen, Augeri, David J, Baumeister, Steven A, Betebenner, David A, Bures, Mark G, Elmore, Steven W, Hajduk, Philip J, Joseph, Mary K, Landis, Shelley K, Nettesheim, David G, Rosenberg, Saul H, Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W

“…The antiapoptotic proteins Bcl-xL and Bcl-2 play key roles in the maintenance of normal cellular homeostasis. However, their overexpression can lead to…”
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Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo by Wendt, Michael D, Shen, Wang, Kunzer, Aaron, McClellan, William J, Bruncko, Milan, Oost, Thorsten K, Ding, Hong, Joseph, Mary K, Zhang, Haichao, Nimmer, Paul M, Ng, Shi-Chung, Shoemaker, Alexander R, Petros, Andrew M, Oleksijew, Anatol, Marsh, Kennan, Bauch, Joy, Oltersdorf, Tilman, Belli, Barbara A, Martineau, Darlene, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

“…Development of a rationally designed potentiator of cancer chemotherapy, via inhibition of Bcl-XL function, is described. Lead compounds generated by NMR…”
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Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL by Bruncko, Milan, Oost, Thorsten K, Belli, Barbara A, Ding, Hong, Joseph, Mary K, Kunzer, Aaron, Martineau, Darlene, McClellan, William J, Mitten, Michael, Ng, Shi-Chung, Nimmer, Paul M, Oltersdorf, Tilman, Park, Cheol-Min, Petros, Andrew M, Shoemaker, Alexander R, Song, Xiaohong, Wang, Xilu, Wendt, Michael D, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

“…Overexpression of the antiapototic proteins Bcl-2 and Bcl-xL provides a common mechanism through which cancer cells gain a survival advantage and become…”
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Laser therapy in diabetic macular edema by Zacharia, George, Bhat, Varsha K, Joseph, Mary K, Ideculla, Thara

“…Diabetic macular edema results in irreversible loss of vision and is the major cause of visual morbidity in patients with Diabetes of adult onset. DCCT trial…”
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Divergence of Genbank and human tumor Bcl-2 sequences and implications for binding affinity to key apoptotic proteins by JOSEPH, Mary K, SOLOMON, Larry R, PETROS, Andrew M, CAI, Jill, SIMMER, Robert L, HAICHAO ZHANG, ROSENBERG, Saul, NG, Shi-Chung

“…Heterodimerization of antiapoptotic and pro-apoptotic Bcl-2 family of proteins provides an important mechanism for apoptosis regulation. Knowledge about key…”
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours by Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao

“…Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL and Bcl-2, are overexpressed…”
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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x L from NMR and Parallel Synthesis by Petros, Andrew M., Dinges, Jurgen, Augeri, David J., Baumeister, Steven A., Betebenner, David A., Bures, Mark G., Elmore, Steven W., Hajduk, Philip J., Joseph, Mary K., Landis, Shelley K., Nettesheim, David G., Rosenberg, Saul H., Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W.

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Proteins Binding to Kallikrein and Esterase A2 in the Urine of Salt-Sensitive and Salt-Resistant Rats by RAPP, JOHN P, JOSEPH, MARY K, MCPARTLAND, RICHARD P

“…Iodine-labeled ([I]) rat urinary kallikrein and rat urinary TAME esterase A2 were used as probes to look for urinary and plasma proteins that bind to these…”
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Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents by Luo, Y, Rockow-Magnone, S K, Joseph, M K, Bradner, J, Butler, C C, Tahir, S K, Han, E K, Ng, S C, Severin, J M, Gubbins, E J, Reilly, R M, Rueter, A, Simmer, R L, Holzman, T F, Giranda, V L

“…Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and…”
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Isolation and partial characterization of rat urinary esterase A2 by McPartland, R P, Rapp, J P, Joseph, M K, Sustarsic, D L

“…An enzyme, esterase A2, which hydrolyzes tosyl-arginine methyl ester was isolated from the urine of female, inbred, Dahl-salt-resistant rats using…”
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