Search Results - "Joseph, Lavania"

Assessment of epidemiological and genetic characteristics and clinical outcomes of resistance to bedaquiline in patients treated for rifampicin-resistant tuberculosis: a cross-sectional and longitudinal study by Ismail, Nazir Ahmed, Omar, Shaheed Vally, Moultrie, Harry, Bhyat, Zaheda, Conradie, Francesca, Enwerem, M, Ferreira, Hannetjie, Hughes, Jennifer, Joseph, Lavania, Kock, Yulene, Letsaolo, Vancy, Maartens, Gary, Meintjes, Graeme, Ngcamu, Dumisani, Okozi, Nana, Padanilam, Xavier, Reuter, Anja, Romero, Rodolf, Schaaf, Simon, te Riele, Julian, Variava, Ebrahim, van der Meulen, Minty, Ismail, Farzana, Ndjeka, Norbert

“…Bedaquiline improves outcomes of patients with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this…”
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Epidemiological cut-offs for Sensititre susceptibility testing of Mycobacterium tuberculosis: interpretive criteria cross validated with whole genome sequencing by Ismail, Nazir A., Ismail, Farzana, Joseph, Lavania, Govender, Netricia, Blows, Linsay, Kaniga, Koné, Omar, Shaheed V.

“…Universal drug susceptibility testing (DST) is an important requirement of the End TB Strategy. The Sensititre broth micro-dilution assay (BMD) tests multiple…”
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Defining Bedaquiline Susceptibility, Resistance, Cross-Resistance and Associated Genetic Determinants: A Retrospective Cohort Study by Ismail, Nazir A., Omar, Shaheed V., Joseph, Lavania, Govender, Netricia, Blows, Linsay, Ismail, Farzana, Koornhof, Hendrik, Dreyer, Andries W., Kaniga, Koné, Ndjeka, Norbert

“…Bedaquiline (BDQ) is a novel agent approved for use in combination treatment of multi-drug resistant tuberculosis (MDR-TB). We sought to determine BDQ…”
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Treatment Outcome of Tubercular Uveitis in a High TB and HIV Setting: A Prospective Cohort Study by Alli, Hassan Dawood, Ally, Naseer, Mayet, Ismail, Joseph, Lavania, Omar, Shaheed, Madhi, Shabir

“…To determine the time to resolution of inflammation in tubercular uveitis (TBU) cases on standard anti-tubercular treatment. Sub-analysis of time to resolution…”
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Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis by Ismail, Nazir A., Said, Halima M., Ismail, Farzana, Ismail, Nabila, Omar, Shaheed V., Gwala, Thabisile L., Joseph, Lavania

“…South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq,…”
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Draft Genome Sequence of Mycobacterium peregrinum Isolated from an HIV-Positive Patient in South Africa by Omar, Shaheed V, Allam, Mushal, Joseph, Lavania, Mtshali, Senzo, Ismail, Nazir A, Ismail, Arshad

“…Here, we report a draft genome sequence of obtained from a sputum sample of a South African HIV-infected patient with suspected pulmonary tuberculosis. The…”
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Whole-Genome Sequence of a Mycobacterium goodii Isolate from a Pediatric Patient in South Africa by Allam, Mushal, Joseph, Lavania, Ismail, Farzana, Said, Halima, Ismail, Nazir A, Ismail, Arshad, Mtshali, Senzo, Mnyameni, Florah, Goussard, Pierre, Pekeur, Jade C, Lourens, Adré, Omar, Shaheed V

“…We describe here the draft genome sequence of a isolate from a pediatric patient in Western Cape, South Africa. To our knowledge, this is the second reported…”
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Validation of Bedaquiline Phenotypic Drug Susceptibility Testing Methods and Breakpoints: a Multilaboratory, Multicountry Study by Kaniga, Koné, Aono, Akio, Borroni, Emanuele, Cirillo, Daniela Maria, Desmaretz, Christel, Hasan, Rumina, Joseph, Lavania, Mitarai, Satoshi, Shakoor, Sadia, Torrea, Gabriela, Ismail, Nazir Ahmed, Omar, Shaheed V

“…Drug-resistant tuberculosis persists as a major public health concern. Alongside efficacious treatments, validated and standardized drug susceptibility testing…”
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Evaluating culture-free targeted next-generation sequencing for diagnosing drug-resistant tuberculosis: a multicentre clinical study of two end-to-end commercial workflows by Colman, Rebecca E, Seifert, Marva, De la Rossa, Andres, Georghiou, Sophia B, Hoogland, Christine, Uplekar, Swapna, Laurent, Sacha, Rodrigues, Camilla, Kambli, Priti, Tukvadze, Nestani, Maghradze, Nino, Omar, Shaheed V, Joseph, Lavania, Suresh, Anita, Rodwell, Timothy C

“…Drug-resistant tuberculosis remains a major obstacle in ending the global tuberculosis epidemic. Deployment of molecular tools for comprehensive drug…”
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Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis by Brown, Tyler S, Tang, Linrui, Omar, Shaheed Vally, Joseph, Lavania, Meintjes, Graeme, Maartens, Gary, Wasserman, Sean, Shah, N Sarita, Farhat, Maha R, Gandhi, Neel R, Ismail, Nazir, Brust, James C M, Mathema, Barun

“…Emerging resistance to bedaquiline (BDQ) threatens to undermine advances in the treatment of drug-resistant tuberculosis (DRTB). Characterizing serial…”
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Application of machine learning techniques to tuberculosis drug resistance analysis by Kouchaki, Samaneh, Yang, Yang, Walker, Timothy M, Sarah Walker, A, Wilson, Daniel J, Peto, Timothy E A, Crook, Derrick W, Clifton, David A

“…Timely identification of Mycobacterium tuberculosis (MTB) resistance to existing drugs is vital to decrease mortality and prevent the amplification of existing…”
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MmpR5 protein truncation and bedaquiline resistance in Mycobacterium tuberculosis isolates from South Africa: a genomic analysis by Roberts, Leah W, Malone, Kerri M, Hunt, Martin, Joseph, Lavania, Wintringer, Penelope, Knaggs, Jeff, Crook, Derrick, Farhat, Maha R, Iqbal, Zamin, Omar, Shaheed V

“…The antibiotic bedaquiline is a key component of new WHO regimens for drug-resistant tuberculosis; however, predicting bedaquiline resistance from bacterial…”
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Tubercular Uveitis in Uveitis Cases in a High TB and HIV Setting: A Prospective Cohort Study by Alli, Hassan D, Ally, Naseer, Mayet, Ismail, Joseph, Lavania, Omar, Shaheed V, Madhi, Shabir A

“…The diagnosis of tubercular uveitis (TBU) is difficult. The lack of a diagnostic gold standard has contributed to challenges in determining the true prevalence…”
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GenomegaMap: Within-Species Genome-Wide dN/dS Estimation from over 10,000 Genomes by Wilson, Daniel J

“…The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess or deficit of amino…”
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