Search Results - "Joseph, L.K."

Artificial intelligence for prostate cancer histopathology diagnostics by Sandoval, Victor, Chuang, Zachary, Power, Nicholas, Chin, Joseph L K

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QUEST at 25: An enduring innovation in Canadian urology by Touma, Naji J, Leveridge, Michael J, Beiko, Darren, Rowe, Neal, Warren, Jeff, Watterson, James, Blais, Anne-Sophie, Wilson, James W L, Morales, Alvaro, Razvi, Hassan, Chin, Joseph L K, MacNeily, Andrew E

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Simple prostatectomy using the open and robotic approaches for lower urinary tract symptoms: A retrospective, case-control series by Golomb, Dor, Berto, Fernanda Gabrigna, Bjazevic, Jennifer, Gomez, Jose A, Chin, Joseph L K, Luke, Patrick P, Pautler, Stephen E

“…We aimed to assess the outcome of our series of simple prostatectomy at our institution using the open simple prostatectomy (OSP) and robotic-assisted simple…”
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Metastatic progression following multimodal therapy for unfavorable-risk prostate cancer by Guy, David, Glicksman, Rachel, Buckley, Roger, Cheung, Patrick, Chung, Hans, Flax, Stanley, Hajek, David, Loblaw, Andrew, Morton, Gerard, Noakes, Jeffery, Spevack, Les, Chin, Joseph L K, Rodrigues, George

“…Identifying the optimal management of unfavorable-risk (Prostate Cancer Risk Stratification [ProCaRS] high intermediate-, high-, and very high-risk categories)…”
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Longitudinal experience with Studer neobladders: Outcomes and complications by Chan, Ernest Pang, Nair, Shiva Madhwan, Hetou, Khalil, Stephenson, Emily, Power, Nicholas E, Izawa, Jonathan, Chin, Joseph L K

“…This study aims to assess the longer-term functional, anatomical, and metabolic outcomes of patients who underwent Studer neobladder (SNB) urinary diversion. A…”
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Neoadjuvant Cabazitaxel plus Abiraterone/Leuprolide Acetate in Patients with High-Risk Prostate Cancer: ACDC-RP Phase II Trial by Fleshner, Neil E., Sayyid, Rashid K., Hansen, Aaron R., Chin, Joseph L.K., Fernandes, Ricardo, Winquist, Eric, van der Kwast, Theodorus, Sweet, Joan, Lajkosz, Katherine, Kenk, Miran, Hersey, Karen, Veloso, Rosette, Berlin, Doron, Herrera-Caceres, Jaime O., Sridhar, Srikala, Moussa, Madeleine, Finelli, Antonio, Hamilton, Robert J., Kulkarni, Girish S., Zlotta, Alexandre R., Joshua, Anthony M.

“…Abstract Purpose: Early treatment intensification with neoadjuvant therapy may improve outcomes in patients with high-risk, localized prostate cancer treated…”
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Glutamatergic Pathway Targeting in Melanoma: Single-Agent and Combinatorial Therapies by HWA JIN LEE, WALL, Brian A, WANGARI-TALBOT, Janet, SHIN, Seung-Shick, ROSENBERG, Stephen, CHAN, Joseph L-K, NAMKOONG, Jin, GOYDOS, James S, CHEN, Suzie

“…Melanoma is a heterogeneous disease where monotherapies are likely to fail due to variations in genomic signatures. B-RAF inhibitors have been clinically…”
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A Phase 0 Trial of Riluzole in Patients with Resectable Stage III and IV Melanoma by YIP, Dana, LE, Maithao N, CHAN, Joseph L.-K, LEE, Jonathan H, MEHNERT, Janice A, YUDD, Anthony, KEMPF, Jeffery, SHIH, Weichung J, CHEN, Suzie, GOYDOS, James S

“…Purpose: Ectopic expression of GRM1 in murine melanocytes results in transformation into a form of melanoma, and more than 60% of human melanoma samples tested…”
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The Glutamate Release Inhibitor Riluzole Decreases Migration, Invasion, and Proliferation of Melanoma Cells by Le, Maithao N., Chan, Joseph L.-K., Rosenberg, Stephen A., Nabatian, Adam S., Merrigan, Kim T., Cohen-Solal, Karine A., Goydos, James S.

“…The goal of this study was to examine the effects of metabotropic glutamate receptor-1 (GRM1) blockade on melanoma anchorage-independent growth and invasion…”
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Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression by Rosenberg, Stephen A, Niglio, Scot A, Salehomoum, Negar, Chan, Joseph L.-K, Jeong, Byeong-Seon, Wen, Yu, Li, Jiadong, Fukui, Jami, Chen, Suzie, Shin, Seung-Shick, Goydos, James S

“…Abstract Our group has previously reported that the majority of human melanomas (> 60%) express the metabotropic glutamate receptor 1 (GRM1) and that the…”
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Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition by Cohen-Solal, Karine A., Merrigan, Kim T., Chan, Joseph L.-K., Goydos, James S., Chen, Wenjin, Foran, David J., Liu, Fang, Lasfar, Ahmed, Reiss, Michael

“…Summary Melanoma cells are resistant to transforming growth factor‐β (TGFβ)‐induced cell‐cycle arrest. In this study, we investigated a mechanism of resistance…”
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Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells by Schlosshauer, Peter W, Li, Wei, Lin, Kai-Ti, Chan, Joseph L.-K, Wang, Lu-Hai

“…Abstract Objective The current standard treatment for ovarian carcinoma, consisting of surgery followed by chemotherapy with carboplatin and paclitaxel, is…”
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Rapamycin together with herceptin significantly increased anti‐tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells by Wang, Lu‐Hai, Chan, Joseph L.‐K., Li, Wei

“…The objective of this study was to assess the anti‐tumor efficacy of rapamycin alone or in combination with herceptin in breast cancer. A total of 20 human…”
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Thermal characterisation of dye-intercalated K-10 montmorillonite ceramics using photoacoustic technique by Joseph, L.K., Sanjay, G., Suja, H., Sugunan, S., Nampoori, V.P.N., Radhakrishnan, P.

“…Thermal diffusivity (TD) measurements were performed on some industrially important dyes - auramine O (AO), malachite green and methylene blue (MB) - adsorbed…”
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The Role of Phosphatidylinositol 3-Kinase, Rho Family GTPases, and STAT3 in Ros-induced Cell Transformation by Nguyen, Kevin T., Zong, Cong S., Uttamsingh, Shailaja, Sachdev, Pallavi, Bhanot, Monica, Le, Mai-Thao, Chan, Joseph L.-K., Wang, Lu-Hai

“…Using loss-of-function mutants of Ros and inducible epidermal growth factor receptor-Ros chimeras we investigated the role of various signaling pathways in…”
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Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells by TRI NGUYEN, Kevin, WANG, Wang-June, CHAN, Joseph L-K, WANG, Lu-Hai

“…There have been few studies on the specific signaling pathways involved in the transformation of epithelial cells by oncogenic protein tyrosine kinases. Here…”
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Effect of Tyrosine Mutations on the Kinase Activity and Transforming Potential of an Oncogenic Human Insulin-like Growth Factor I Receptor (∗) by Jiang, Yixing, Chan, Joseph L.-K., Zong, Cong S., Wang, Lu-Hai

“…The tyrosines in the cytoplasmic domain of an oncogenic human insulin-like growth factor I receptor (gag-IGFR) were systematically mutated to phenylalanines to…”
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Mutations of Ros Differentially Effecting Signal Transduction Pathways Leading to Cell Growth Versus Transformation by Zong, Cong S., Chan, Joseph L.-K., Yang, Sheng-Kai, Wang, Lu-Hai

“…The signaling functions of the oncogenic protein-tyrosine kinase v-Ros were studied by systematically mutating the tyrosine residues in its cytoplasmic domain…”
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Two chimeric receptors of epidermal growth factor receptor and c-Ros that differ in their transmembrane domains have opposite effects on cell growth by Xiong, Qinghua, Chan, Joseph L.-K., Zong, Cong S., Wang, Lu-Hai

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Effect of Dimerization on Signal Transduction and Biological Function of Oncogenic Ros, Insulin, and Insulin-like Growth Factor I Receptors by Chan, J L, Lai, M, Wang, L H

“…The avian sarcoma virus UR2 codes for an oncogenic Gag-Ros fusion protein-tyrosine kinase (PTK). We have previously derived two retroviruses, T6 and NM1,…”
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