Search Results - "Joseph, Jamie W"

Kinetic modelling of β‐cell metabolism reveals control points in the insulin‐regulating pyruvate cycling pathways by Rahul, Rahul, Stinchcombe, Adam R., Joseph, Jamie W., Ingalls, Brian

“…Insulin, a key hormone in the regulation of glucose homoeostasis, is secreted by pancreatic β‐cells in response to elevated glucose levels. Insulin is released…”
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Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion by Patterson, Jessica N., Cousteils, Katelyn, Lou, Jennifer W., Manning Fox, Jocelyn E., MacDonald, Patrick E., Joseph, Jamie W.

“…It is well known that mitochondrial metabolism of pyruvate is critical for insulin secretion; however, we know little about how pyruvate is transported into…”
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Metabolic cycling in control of glucose-stimulated insulin secretion by Jensen, Mette V, Joseph, Jamie W, Ronnebaum, Sarah M, Burgess, Shawn C, Sherry, A Dean, Newgard, Christopher B

“…Glucose-stimulated insulin secretion (GSIS) is central to normal control of metabolic fuel homeostasis, and its impairment is a key element of beta-cell…”
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Glucose-sensing mechanisms in pancreatic β-cells by MacDonald, Patrick E, Joseph, Jamie W, Rorsman, Patrik

“…The appropriate secretion of insulin from pancreatic β-cells is critically important to the maintenance of energy homeostasis. The β-cells must sense and…”
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Effect of N-acetyl-l-cysteine on insulin resistance caused by prolonged free fatty acid elevation by Pereira, Sandra, Shah, Anu, George Fantus, I, W Joseph, Jamie, Giacca, Adria

“…Circulating free fatty acids (FFAs) are elevated in obesity and cause insulin resistance. The objective of the current study was to determine whether the…”
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Do Ketone Supplements Regulate Islet Hormone Secretion? by Joseph, Jamie W

“…Ketone supplementation has been gaining interest in improving health and treating some diseases, such as diabetes. However, the mechanism of action of how…”
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Therapeutic Potential of Blocking Nephrin Phosphorylation to Improve Pancreatic β-cell Function by Joseph, Jamie W

“…Abstract The phosphorylation of the transmembrane protein nephrin has been shown to play an important role in signaling in kidney podocytes, and it has now…”
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Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance by Nahle, Ashraf, Joseph, Yemisi Deborah, Pereira, Sandra, Mori, Yusaku, Poon, Frankie, Ghadieh, Hilda E, Ivovic, Aleksandar, Desai, Tejas, Ghanem, Simona S, Asalla, Suman, Muturi, Harrison T, Jentz, Emelien M, Joseph, Jamie W, Najjar, Sonia M, Giacca, Adria

“…The NAD-dependent deacetylase SIRT1 improves β cell function. Accordingly, nicotinamide mononucleotide (NMN), the product of the rate-limiting step in NAD…”
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A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion by Ronnebaum, Sarah M., Ilkayeva, Olga, Burgess, Shawn C., Joseph, Jamie W., Lu, Danhong, Stevens, Robert D., Becker, Thomas C., Sherry, A. Dean, Newgard, Christopher B., Jensen, Mette V.

“…Glucose-stimulated insulin secretion (GSIS) from pancreatic islet β-cells is central to control of mammalian fuel homeostasis. Glucose metabolism mediates GSIS…”
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The Mitochondrial Citrate/Isocitrate Carrier Plays a Regulatory Role in Glucose-stimulated Insulin Secretion by Joseph, Jamie W., Jensen, Mette V., Ilkayeva, Olga, Palmieri, Ferdinando, Alárcon, Cristina, Rhodes, Christopher J., Newgard, Christopher B.

“…Glucose-stimulated insulin secretion (GSIS) is mediated in part by glucose metabolism-driven increases in ATP/ADP ratio, but by-products of mitochondrial…”
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Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity by Fernandes, Maria F., Aristizabal-Henao, Juan J., Marvyn, Phillip M., M'Hiri, Iman, Wiens, Meghan A., Hoang, Monica, Sebastian, Manuel, Nachbar, Renato, St-Pierre, Philippe, Diaguarachchige De Silva, Kalsha, Wood, Geoffrey A., Joseph, Jamie W., Doucette, Christine A., Marette, André, Stark, Ken D., Duncan, Robin E.

“…Lipotoxic injury from renal lipid accumulation in obesity and type 2 diabetes (T2D) is implicated in associated kidney damage. However, models examining…”
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Prevention of Lipotoxicity in Pancreatic Islets with Gammahydroxybutyrate by Yung, Justin Hou Ming, Yeung, Lucy Shu Nga, Ivovic, Aleksandar, Tan, Yao Fang, Jentz, Emelien Mariella, Batchuluun, Battsetseg, Gohil, Himaben, Wheeler, Michael B, Joseph, Jamie W, Giacca, Adria, Mamelak, Mortimer

“…Oxidative stress caused by the exposure of pancreatic ß-cells to high levels of fatty acids impairs insulin secretion. This lipotoxicity is thought to play an…”
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Metabolomic analysis of pancreatic β-cell insulin release in response to glucose by Huang, Mei, Joseph, Jamie W.

“…Defining the key metabolic pathways that are important for fuel-regulated insulin secretion is critical to providing a complete picture of how nutrients…”
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Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet by Joseph, Jamie W, Koshkin, Vasilij, Zhang, Chen-Yu, Wang, Jing, Lowell, Bradford B, Chan, Catherine B, Wheeler, Michael B

“…Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet Jamie W. Joseph 1 , Vasilij Koshkin 1 , Chen-Yu Zhang 2 ,…”
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Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion by Joseph, Jamie W., Odegaard, Matthew L., Ronnebaum, Sarah M., Burgess, Shawn C., Muehlbauer, Jeffrey, Sherry, A. Dean, Newgard, Christopher B.

“…It has been proposed that de novo synthesis of long-chain acyl-CoA (LC-CoA) is a signal for glucose-stimulated insulin secretion (GSIS). Key enzymes involved…”
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Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice by Nasteska, Daniela, Cuozzo, Federica, Viloria, Katrina, Johnson, Elspeth M, Thakker, Alpesh, Bany Bakar, Rula, Westbrook, Rebecca L, Barlow, Jonathan P, Hoang, Monica, Joseph, Jamie W, Lavery, Gareth G, Akerman, Ildem, Cantley, James, Hodson, Leanne, Tennant, Daniel A, Hodson, David J

“…The α-ketoglutarate-dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is an HIF target that uses molecular oxygen to hydroxylate peptidyl prolyl residues…”
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Peroxisome Proliferator–Activated Receptor-α Agonist Treatment in a Transgenic Model of Type 2 Diabetes Reverses the Lipotoxic State and Improves Glucose Homeostasis by KIM, Hyunsook, HALUZIK, Martin, WHEELER, Michael B, LEROITH, Derek, ASGHAR, Zeenat, DAPHNE YAU, JOSEPH, Jamie W, FERNANDEZ, Ana M, REITMAN, Marc L, YAKAR, Shoshana, STANNARD, Bethel, HERON-MILHAVET, Lisa

“…Peroxisome Proliferator–Activated Receptor-α Agonist Treatment in a Transgenic Model of Type 2 Diabetes Reverses the Lipotoxic State and Improves Glucose…”
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Assessment of the Metabolic Pathways Associated With Glucose-Stimulated Biphasic Insulin Secretion by Huang, Mei, Joseph, Jamie W

“…Biphasic glucose-stimulated insulin secretion involves a rapid first phase followed by a prolonged second phase of insulin secretion. The biochemical pathways…”
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Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death by Lee, Eric A, Angka, Leonard, Rota, Sarah-Grace, Hanlon, Thomas, Mitchell, Andrew, Hurren, Rose, Wang, Xiao Ming, Gronda, Marcela, Boyaci, Ezel, Bojko, Barbara, Minden, Mark, Sriskanthadevan, Shrivani, Datti, Alessandro, Wrana, Jeffery L, Edginton, Andrea, Pawliszyn, Janusz, Joseph, Jamie W, Quadrilatero, Joe, Schimmer, Aaron D, Spagnuolo, Paul A

“…Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes. Through a high-throughput cell-based screen, we identified…”
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The Loss of ARNT/HIF1β in Male Pancreatic β-Cells Is Protective Against High-Fat Diet-Induced Diabetes by Hoang, Monica, Paglialunga, Sabina, Bombardier, Eric, Tupling, A Russell, Joseph, Jamie W

“…The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT)/hypoxia-inducible factor (HIF)-1β (ARNT/HIF1β) plays a key role in maintaining…”
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