Search Results - "Joseph, James A"

Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia by Lau, Francis C., Bielinski, Donna F., Joseph, James A.

“…Sustained microglial activation in the central nervous system (CNS) has been extensively investigated in age‐related neurodegenerative diseases and has been…”
Get full text

Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds by JOSEPH, James A, SHUKITT-HALE, Barbara, CASADESUS, Gemma

“…Despite elegant research involving molecular biology studies and determination of the genetic mechanisms of aging, practical information on how to forestall or…”
Get full text

Effects of blackberries on motor and cognitive function in aged rats by Shukitt-Hale, Barbara, Cheng, Vivian, Joseph, James A.

“…The polyphenolics in fruits and vegetables, when fed to rats from 19-21 months of age, have been shown to retard and even reverse age-related decrements in…”
Get full text

Blueberry-Enriched Diet Attenuates Nephropathy in a Rat Model of Hypertension via Reduction in Oxidative Stress by Elks, Carrie M, Reed, Scott D, Mariappan, Nithya, Shukitt-Hale, Barbara, Joseph, James A, Ingram, Donald K, Francis, Joseph, Zoccali, Carmine

“…To assess renoprotective effects of a blueberry-enriched diet in a rat model of hypertension. Oxidative stress (OS) appears to be involved in the development…”
Get full text

Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid–rich plant foods by Willis, Lauren M, Shukitt-Hale, Barbara, Joseph, James A

“…Aging results in the development of cognitive and motor deficits in humans and animals that are evident by midlife. These deficits are thought to stem from…”
Get full text

Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging by Shukitt-Hale, Barbara, Carey, Amanda N, Jenkins, Daniel, Rabin, Bernard M, Joseph, James A

“…Abstract Exposing young rats to particles of high-energy and charge (HZE particles) enhances indices of oxidative stress and inflammation and disrupts the…”
Get full text

Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans by Wilson, Mark A., Shukitt‐Hale, Barbara, Kalt, Wilhelmina, Ingram, Donald K., Joseph, James A., Wolkow, Catherine A.

“…Summary The beneficial effects of polyphenol compounds in fruits and vegetables are mainly extrapolated from in vitro studies or short‐term dietary…”
Get full text

A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects by Youdim, Kuresh A, Joseph, James A

“…It is rare to see a day pass in which we are not told through some popular medium that the population is becoming older. Along with this information comes the…”
Get full text

The beneficial effects of fruit polyphenols on brain aging by Lau, Francis C., Shukitt-Hale, Barbara, Joseph, James A.

“…Brain aging is characterized by the continual concession to battle against insults accumulated over the years. One of the major insults is oxidative stress,…”
Get full text

Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory by Andres-Lacueva, Cristina, Shukitt-Hale, Barbara, Galli, Rachel L., Jauregui, Olga, Lamuela-Raventos, Rosa M., Joseph, James A.

“…Research has shown that fruits and vegetables containing high levels of polyphenolics (flavonoids) display high total antioxidant activity. Our laboratory…”
Get full text

Effects of Concord grape juice on cognitive and motor deficits in aging by Shukitt-Hale, Barbara, Carey, Amanda, Simon, Laura, Mark, David A., Joseph, James A.

“…Animals and humans show increased motor and cognitive declines with aging that are thought to be due to increased susceptibility to the long-term effects of…”
Get full text

Blueberry-Enriched Diet Protects Rat Heart from Ischemic Damage by Ahmet, Ismayil, Spangler, Edward, Shukitt-Hale, Barbara, Juhaszova, Magdalena, Sollott, Steven J, Joseph, James A, Ingram, Donald K, Talan, Mark

“…Objectives: to assess the cardioprotective properties of a blueberry enriched diet (BD). Background: Reactive oxygen species (ROS) play a major role in…”
Get full text

Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats by Malin, David H., Ph.D, Lee, David R., M.A., M.S, Goyarzu, Pilar, Ph.D, Chang, Yu-Hsuan, M.A, Ennis, Lalanya J., M.A, Beckett, Elizabeth, M.A, Shukitt-Hale, Barbara, Ph.D, Joseph, James A., Ph.D

“…Abstract Objective Previously, 4 mo of a blueberry-enriched (BB) antioxidant diet prevented impaired object recognition memory in aging rats. Experiment 1…”
Get full text

The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells by Carey, Amanda N., Fisher, Derek R., Joseph, James A., Shukitt-Hale, Barbara

“…Previous research from our lab has demonstrated that dietary walnut supplementation protects against age-related cognitive declines in rats; however, the…”
Get full text

Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus by Shukitt-Hale, Barbara, Lau, Francis C., Carey, Amanda N., Galli, Rachel L., Spangler, Edward L., Ingram, Donald K., Joseph, James A.

“…Cognitive impairment in age-related neurodegenerative diseases such as Alzheimer's disease may be partly due to long-term exposure and increased susceptibility…”
Get full text

Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats by Casadesus, Gemma, Shukitt-Hale, Barbara, Stellwagen, Heather M., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Joseph, James A.

“…During aging, reductions in hippocampal neurogenesis are associated with memory decline indicating a causal relationship. Indeed, insulin-like growth factor-1…”
Get full text

Survival and Cardioprotective Benefits of Long-Term Blueberry Enriched Diet in Dilated Cardiomyopathy Following Myocardial Infarction in Rats by Ahmet, Ismayil, Spangler, Edward, Shukitt-Hale, Barbara, Joseph, James A, Ingram, Donald K, Talan, Mark

“…Background: Despite remarkable progress in treatment of chronic heart failure (CHF) over the last two decades, mortality, personal suffering and cost remain…”
Get full text

Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats by Shukitt-Hale, Barbara, Ph.D, Kalt, Wilhelmina, Ph.D, Carey, Amanda N., M.A, Vinqvist-Tymchuk, Melinda, M.S, McDonald, Jane, B.S, Joseph, James A., Ph.D

“…Abstract Objective Normal aging in animals and humans is accompanied by a decline in cognitive performance that is thought to be due to the long-term effects…”
Get full text

Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial by Miller, Marshall G., Hamilton, Derek A., Joseph, James A., Shukitt-Hale, Barbara

“…Purpose As populations shift to include a larger proportion of older adults, the necessity of research targeting older populations is becoming increasingly…”
Get full text

Grape juice, berries, and walnuts affect brain aging and behavior by Joseph, James A, Shukitt-Hale, Barbara, Willis, Lauren M

“…Numerous studies have indicated that individuals consuming a diet containing high amounts of fruits and vegetables exhibit fewer age-related diseases such as…”
Get more information