Search Results - "Joseph, D P"

Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation by O'Boyle, Graeme, Fox, Christopher R. J, Walden, Hannah R, Willet, Joseph D. P, Mavin, Emily R, Hine, Dominic W, Palmer, Jeremy M, Barker, Catriona E, Lamb, Christopher A, Ali, Simi, Kirby, John A

“…The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed by these cells…”
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Identification of Heterozygous Single- and Multi-exon Deletions in IL7R by Whole Exome Sequencing by Engelhardt, Karin R., Xu, Yaobo, Grainger, Angela, Germani Batacchi, Mila G. C., Swan, David J., Willet, Joseph D. P., Abd Hamid, Intan J., Agyeman, Philipp, Barge, Dawn, Bibi, Shahnaz, Jenkins, Lucy, Flood, Terence J., Abinun, Mario, Slatter, Mary A., Gennery, Andrew R., Cant, Andrew J., Santibanez Koref, Mauro, Gilmour, Kimberly, Hambleton, Sophie

“…Purpose We aimed to achieve a retrospective molecular diagnosis by applying state-of-the-art genomic sequencing methods to past patients with T-B+NK+ severe…”
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Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency by Dang, Tarana Singh, Willet, Joseph DP, Griffin, Helen R, Morgan, Neil V, O’Boyle, Graeme, Arkwright, Peter D, Hughes, Stephen M, Abinun, Mario, Tee, Louise J, Barge, Dawn, Engelhardt, Karin R, Jackson, Michael, Cant, Andrew J, Maher, Eamonn R, Koref, Mauro Santibanez, Reynard, Louise N, Ali, Simi, Hambleton, Sophie

“…Purpose To investigate the clinical and functional aspects of MST1 ( STK4 ) deficiency in a profoundly CD4-lymphopenic kindred with a novel homozygous nonsense…”
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Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain by Acres, Meghan J., Gothe, Florian, Grainger, Angela, Skelton, Andrew J., Swan, David J., Willet, Joseph D.P., Leech, Suzy, Galcheva, Sonya, Iotova, Violeta, Hambleton, Sophie, Engelhardt, Karin R.

“…Compared with 3 controls, the patient showed reduced STAT5 phosphorylation (Fig 2, E). Because the antibody used recognizes phosphorylated STAT5A and STAT5B,…”
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Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in TNFAIP3 (A20) by Duncan, Christopher J A, Dinnigan, Emma, Theobald, Rachel, Grainger, Angela, Skelton, Andrew J, Hussain, Rafiqul, Willet, Joseph D P, Swan, David J, Coxhead, Jonathan, Thomas, Matthew F, Thomas, Julian, Zamvar, Veena, Slatter, Mary A, Cant, Andrew J, Engelhardt, Karin R, Hambleton, Sophie

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Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-β by Willet, Joseph D. P., Pichitsiri, Watchara, Jenkinson, Sarah E., Brain, John G., Wood, Katrina, Alhasan, Abd A., Spielhofer, Julia, Robertson, Helen, Ali, Simi, Kirby, John A.

“…T cells activate latent TGF‐β by an LSKL peptide‐sensitive mechanism, suggesting a role for thrombospondin‐1 in T cell differentiation after kidney…”
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Erratum to: Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency by Dang, Tarana Singh, Willet, Joseph D. P., Griffin, Helen R., Morgan, Neil V., O’Boyle, Graeme, Arkwright, Peter D., Hughes, Stephen M., Abinun, Mario, Tee, Louise J., Barge, Dawn, Engelhardt, Karin R., Jackson, Michael, Cant, Andrew J., Maher, Eamonn R., Koref, Mauro Santibanez, Reynard, Louise N., Ali, Simi, Hambleton, Sophie

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Renal allograft rejection: Examination of delayed differentiation of Treg and Th17 effector T cells by Pekalski, Marcin, Jenkinson, Sarah E, Willet, Joseph D.P, Poyner, Elizabeth F.M, Alhamidi, Abdulaziz H, Robertson, Helen, Ali, Simi, Kirby, John A

“…Abstract Antigen presentation after kidney transplantation occurs in lymphoid tissues remote from the allograft, with activated T cells then migrating towards…”
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Apical and basal membrane ion transport mechanisms in bovine retinal pigment epithelium by Joseph, D P, Miller, S S

“…1. Intracellular voltage recordings using conventional and double-barrelled chloride-selective microelectrodes have been used to identify several transport…”
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Facilitators of Self-Initiated HIV Testing Among Youths: A Qualitative Study by ADEBAYO, Oluwamuyiwa Winifred, DE SANTIS, Joseph P., GATTAMORTA, Karina A., VILLEGAS, Natalia Andrea

“…Background: Youth experience disparities in HIV infection but have significantly low rates of HIV testing that lead to late diagnoses, increased transmission…”
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NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome by Chen, Rui, Lukianova, Elena, van der Loeff, Ina Schim, Spegarova, Jarmila Stremenova, Willet, Joseph D P, James, Kieran D, Ryder, Edward J, Griffin, Helen, IJspeert, Hanna, Gajbhiye, Akshada, Lamoliatte, Frederic, Marin-Rubio, Jose L, Woodbine, Lisa, Lemos, Henrique, Swan, David J, Pintar, Valeria, Sayes, Kamal, Ruiz-Morales, Elias R, Eastham, Simon, Dixon, David, Prete, Martin, Prigmore, Elena, Jeggo, Penny, Boyes, Joan, Mellor, Andrew, Huang, Lei, van der Burg, Mirjam, Engelhardt, Karin R, Stray-Pedersen, Asbjørg, Erichsen, Hans Christian, Gennery, Andrew R, Trost, Matthias, Adams, David J, Anderson, Graham, Lorenc, Anna, Trynka, Gosia, Hambleton, Sophie

“…Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 11 affected patients…”
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Ocular photodynamic therapy with verteporfin for choroidal neovascularization secondary to ocular histoplasmosis syndrome by Busquets, M A, Shah, G K, Wickens, J, Callanan, D, Blinder, K J, Burgess, D, Grand, M G, Holekamp, N M, Boniuk, I, Joseph, D P, Thomas, M A, Fish, E, Bakal, J, Hollands, H, Sharma, S

“…To evaluate the use of ocular photodynamic therapy (OPT) with verteporfin in patients with choroidal neovascularization (CNV) from ocular histoplasmosis…”
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The delayed basolateral membrane hyperpolarization of the bovine retinal pigment epithelium: mechanism of generation by Bialek, S, Joseph, D P, Miller, S S

“…1. Conventional and ion-selective double-barrelled microelectrodes were used in an in vitro preparation of bovine retinal pigment epithelium (RPE)-choroid to…”
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Grading Osteoarthritic Changes of the Zygapophyseal Joints from Radiographs: A Reliability Study by Little, Joshua W., DC, PhD, Grieve, Thomas J., DC, MPH, Cramer, Gregory D., DC, PhD, Rich, Jeffrey A., DC, Laptook, Evelyn E., MS, DC, Stiefel, Joseph P.D., MS, EdD, DC, Linaker, Kathleen, DC, PhD

“…Abstract Objective This study tested the reliability of a 5-point ordinal scale used to grade the severity of degenerative changes of zygapophyseal (Z) joints…”
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Biotransformation of Nevirapine, a Non-nucleoside HIV-1 Reverse Transcriptase Inhibitor, in Mice, Rats, Rabbits, Dogs, Monkeys, and Chimpanzees by RISKA, P. S, JOSEPH, D. P, DINALLO, R. M, DAVIDSON, W. C, KEIRNS, J. J, HATTOX, S. E

“…The study objectives were to characterize the metabolism of nevirapine (NVP) in mouse, rat, rabbit, dog, monkey, and chimpanzee after oral administration of…”
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T Cell‐mediated biliary epithelial‐to‐mesenchymal transition in liver allograft rejection by Rygiel, Karolina A., Robertson, Helen, Willet, Joseph D. P., Brain, John G., Burt, Alastair D., Jones, David E. J., Kirby, John A.

“…Loss of bile duct epithelium is characteristic of early chronic rejection following liver transplantation. Recent studies have suggested that intrahepatic…”
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Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 7. 8-Arylethyldipyridodiazepinones as Potent Broad-Spectrum Inhibitors of Wild-Type and Mutant Enzymes by Klunder, Janice M, Hoermann, MaryAnn, Cywin, Charles L, David, Eva, Brickwood, Janice R, Schwartz, Racheline, Barringer, Kevin J, Pauletti, Daniel, Shih, Cheng-Kon, Erickson, David A, Sorge, Christopher L, Joseph, David P, Hattox, Susan E, Adams, Julian, Grob, Peter M

“…Like other nonnucleoside inhibitors of HIV-1 reverse transcriptase, the dipyridodiazepinone nevirapine (Viramune, 1) selects for drug resistant variants of…”
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Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 8. 8-Aryloxymethyl- and 8-Arylthiomethyldipyridodiazepinones by Cywin, Charles L, Klunder, Janice M, Hoermann, MaryAnn, Brickwood, Janice R, David, Eva, Grob, Peter M, Schwartz, Racheline, Pauletti, Daniel, Barringer, Kevin J, Shih, Cheng-Kon, Sorge, Christopher L, Erickson, David A, Joseph, David P, Hattox, Susan E

“…Nevirapine (I) is the first human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitor to reach regulatory approval. As a…”
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Apical and basolateral membrane mechanisms that regulate pHi in bovine retinal pigment epithelium by Kenyon, E, Maminishkis, A, Joseph, D P, Miller, S S

“…pH regulation was studied in fresh explant bovine retinal pigment epithelium-choroid using the pH-sensitive dye 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein…”
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cAMP stimulates the Na+-K+ pump in frog retinal pigment epithelium by Hughes, B A, Miller, S S, Joseph, D P, Edelman, J L

“…Adenosine 3', 5'-cyclic monophosphate (cAMP) induced increases in active Na+ secretion and K+ absorption that were blocked by apical ouabain (10(-4) M),…”
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