Search Results - "Josef, Kurt"

Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation by Merrick, Deborah, Stadler, Lukas Kurt Josef, Larner, Dean, Smith, Janet

“…Examination of embryonic myogenesis of two distinct, but functionally related, skeletal muscle dystrophy mutants (mdx and cav-3(-/-)) establishes for the first…”
Get full text

1,2-Benzothiazine 1,1-Dioxide P2−P3 Peptide Mimetic Aldehyde Calpain I Inhibitors by Wells, Gregory J, Tao, Ming, Josef, Kurt A, Bihovsky, Ron

“…A series of peptide mimetic aldehyde inhibitors of calpain I was prepared in which the P2 and P3 amino acids were replaced by substituted…”
Get full text

Poster 78 Novel Bimodal Technology Addresses Vitamin D Malabsorption by Kreb, Robert, MD, MPH, Hunt, Maxwell, N/A, Josef, Kurt, BS

Get full text

Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists by Josef, Kurt A., Aimone, Lisa D., Lyons, Jacquelyn, Raddatz, Rita, Hudkins, Robert L.

“…A novel class of benzocinnolinones analogs of irdabisant were designed and synthesized as histamine H3R antagonists/inverse agonists. Modifications to the…”
Get full text

4-Phenoxypiperidine pyridazin-3-one histamine H3 receptor inverse agonists demonstrating potent and robust wake promoting activity by Hudkins, Robert L., Zulli, Allison L., Dandu, Reddeppa reddy, Tao, Ming, Josef, Kurt A., Aimone, Lisa D., Curtis Haltiwanger, R., Huang, Zeqi, Lyons, Jacquelyn A., Mathiasen, Joanne R., Raddatz, Rita, Gruner, John A.

“…Structure–activity relationships for a series of phenoxypiperidine pyridazin-3-one H3R antagonists/inverse agonists are disclosed. The search for compounds…”
Get full text

Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models by Hudkins, Robert L, Diebold, James L, Tao, Ming, Josef, Kurt A, Park, Chung Ho, Angeles, Thelma S, Aimone, Lisa D, Husten, Jean, Ator, Mark A, Meyer, Sheryl L, Holskin, Beverly P, Durkin, John T, Fedorov, Alexander A, Fedorov, Elena V, Almo, Steven C, Mathiasen, Joanne R, Bozyczko-Coyne, Donna, Saporito, Michael S, Scott, Richard W, Mallamo, John P

“…The optimization of the dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-one R2 and R12 positions led to the identification of the first MLK1 and MLK3…”
Get full text

4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists by Hudkins, Robert L., Aimone, Lisa D., Dandu, Reddeppa reddy, Dunn, Derek, Gruner, John A., Huang, Zeqi, Josef, Kurt A., Lyons, Jacquelyn A., Mathiasen, Joanne R., Tao, Ming, Zulli, Allison L., Raddatz, Rita

“…H3R structure–activity relationships for a new class of 4,5-dihydropyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modification of the…”
Get full text

Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity by Hudkins, Robert L., Aimone, Lisa D., Bailey, Thomas R., Bendesky, Robert J., Dandu, Reddeppa reddy, Dunn, Derek, Gruner, John A., Josef, Kurt A., Lin, Yin-Guo, Lyons, Jacquelyn, Marcy, Val R., Mathiasen, Joanne R., Sundar, Babu G., Tao, Ming, Zulli, Allison L., Raddatz, Rita, Bacon, Edward R.

“…H3R structure–activity relationships on a novel class of pyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone…”
Get full text

Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): Histamine H3 receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity by Hudkins, Robert L., Josef, Kurt A., Becknell, Nadine C., Aimone, Lisa D., Lyons, Jacquelyn A., Mathiasen, Joanne R., Gruner, John A., Raddatz, Rita

Get full text

Peptide aptamer microarrays: bridging the bio-detector interface by Song, Qifeng, Stadler, Lukas Kurt Josef, Peng, Jianhe, Ko Ferrigno, Paul

“…In the near future, personalised medicine and phase-0 trials will require that clinical practitioners move from the "one biomarker per disease" paradigm to the…”
Get more information

Conformationally restrained analogs of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor by D'Ambra, Thomas E, Estep, Kimberly G, Bell, Malcolm R, Eissenstat, Michael A, Josef, Kurt A, Ward, Susan J, Haycock, Dean A, Baizman, Eugene R, Casiano, Frances M

“…Pravadoline (1) is an (aminoalkyl)indole analgesic agent which is an inhibitor of cyclooxygenase and, in contrast to other NSAIDs, inhibits neuronally…”
Get full text

Potent peptide α-Ketohydroxamate inhibitors of recombinant human calpain I by Josef, Kurt A, Kauer, Frederick W, Bihovsky, Ron

“…A series of potent dipeptide and tripeptide α-ketohydroxamic esters was prepared as inhibitors of recombinant human calpain I. Compound 3c, a Cbz-Leu-Phe…”
Get full text

Does political and social feasibility matter in energy scenarios? by Schubert, Daniel Kurt Josef, Thuß, Sebastian, Möst, Dominik

“…Scenarios have become an influential tool in the process of energy system transitions, as they form a basis for, e.g., investment decisions or legislative…”
Get full text

1,3,5-Trialkyl-2,4,6-triiodobenzenes:  Novel X-ray Contrast Agents for Gastrointestinal Imaging by Estep, Kimberly G, Josef, Kurt A, Bacon, Edward R, Illig, Carl R, Toner, John L, Mishra, Dinesh, Blazak, William F, Miller, Dennis M, Johnson, David K, Allen, Jack M, Spencer, Andy, Wilson, Susan A

“…Examination of the gastrointestinal (GI) tract has been performed for decades using barium sulfate. Although this agent has many recognized limitations…”
Get full text

Synthesis and Structure-Activity Relationships of 6-Heterocyclic-Substituted Purines as Inactivation Modifiers of Cardiac Sodium Channels by Estep, Kimberly G, Josef, Kurt A, Bacon, Edward R, Carabateas, Philip M, Rumney, Squire, Pilling, Garry M, Krafte, Douglas S, Volberg, Walter A, Dillon, Kathleen, Dugrenier, Nancy, Briggs, G. Maurice, Canniff, Paul C, Gorczyca, William P, Stankus, Gerald P, Ezrin, Alan M

“…Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in…”
Get full text

Wann kommt die Kostenwende bei der EEG-Umlage? Eine Analyse der Entwicklung und Einflussparameter bis 2030 by Schubert, Daniel Kurt Josef, Hinz, Fabian, Dierle, Matthias, Möst, Dominik

“…The apportionment of the German Renewable Energy Sources Act (EEG-Umlage) constitutes a significant portion of the electricity price for domestic and…”
Get full text

SACRED TREES AMONG THE TAMIL PEOPLE OF SOUTH INDIA by Kurt Josef Walter

“…Among the Tamil people of South India the veneration of trees and forests still occupies an important part of their daily life. Once recognized as the abode of…”
Get full text

Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bi c yclo[4.1.0]hept-4-en-2-one (R,S-4a): Histamine H3 receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity by Hudkins, Robert, Josef, Kurt, Becknell, Nadine, Aimone, Lisa, Lyons, Jacquelyn, Mathiasen, Joanne, Gruner, John, Raddatz, Rita

“…A series of fused cyclopropyl-4,5-dihydropyridazin-3-one (3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one) phenoxypiperidine analogs was designed and synthesized,…”
Get full text

1,2-Benzothiazine 1,1-Dioxide P 2 −P 3 Peptide Mimetic Aldehyde Calpain I Inhibitors by Wells, Gregory J., Tao, Ming, Josef, Kurt A., Bihovsky, Ron

Get full text

Structure−function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant by Stadler, Lukas Kurt Josef, Hoffmann, Toni, Tomlinson, Darren Charles, Song, Qifeng, Lee, Tracy, Busby, Michael, Nyathi, Yvonne, Gendra, Elisenda, Tiede, Christian, Flanagan, Keith, Cockell, Simon J., Wipat, Anil, Harwood, Colin, Wagner, Simon D., Knowles, Margaret A., Davis, Jason J., Keegan, Neil, Ko Ferrigno, Paul

“…Constrained binding peptides (peptide aptamers) may serve as tools to explore protein conformations and disrupt protein−protein interactions. The quality of…”
Get full text