Search Results - "Jose Joao Mansure"
-
1
INTEGRATING NOVEL IMMUNOTHERAPEUTIC APPROACHES IN ORGAN-PRESERVING THERAPIES FOR BLADDER CANCER
Published in British journal of pharmacology (16-01-2024)“…Bladder cancer is a prevalent malignancy with significant morbidity and mortality. Over the years, the landscape of bladder cancer treatment has witnessed…”
Get full text
Journal Article -
2
Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer
Published in Nature communications (13-05-2021)“…Radiation therapy (RT) is used in the management of several cancers; however, tumor radioresistance remains a challenge. Polymorphonuclear neutrophils (PMNs)…”
Get full text
Journal Article -
3
Phase 1 Trial of Atezolizumab Plus Trimodal Therapy in Patients With Localized Muscle-Invasive Bladder Cancer
Published in International journal of radiation oncology, biology, physics (01-07-2021)“…Immune checkpoint programmed death-ligand 1 inhibitor therapy has shown response in metastatic muscle invasive bladder cancer (MIBC). We evaluated the safety…”
Get full text
Journal Article -
4
The Role of HMGB1 in Radioresistance of Bladder Cancer
Published in Molecular cancer therapeutics (01-03-2016)“…Although radical cystectomy surgery is the standard-of-care for muscle-invasive bladder cancer, it entails complete removal of the bladder and surrounding…”
Get full text
Journal Article -
5
Presence of lymphocytic infiltrate cytotoxic T lymphocyte CD3+, CD8+, and immunoscore as prognostic marker in patients after radical cystectomy
Published in PloS one (11-10-2018)“…Tumor-Infiltrating Lymphocytes (TILs) has been shown to be essential to predict disease outcome in several types of cancers. Moreover, the distribution of…”
Get full text
Journal Article -
6
Adjuvant therapy in stage III endometrial cancer confined to the pelvis
Published in Gynecologic oncology (01-01-2019)“…To review outcomes of patients with stage III endometrial cancer confined to the pelvis treated with adjuvant pelvic radiotherapy (RT) or sequential…”
Get full text
Journal Article -
7
Effects of combined radiotherapy with immune checkpoint blockade on immunological memory in luminal-like subtype murine bladder cancer model
Published in Cancer biology & therapy (31-12-2024)“…MIBC is a highly lethal disease, and the patient survival rate has not improved significantly over the last decades. UPPL is a cell line that can be used to…”
Get full text
Journal Article -
8
Programmed cell death ligand-1 expression in tumor and immune cells is associated with better patient outcome and decreased tumor-infiltrating lymphocytes in uveal melanoma
Published in Modern pathology (01-08-2018)“…Programmed cell death-1/ligand (PD-1/PD-L1) interaction negatively regulates T cell activity. PD-L1 expression in tumor cells, antigen-presenting cells, and…”
Get full text
Journal Article -
9
Prognostic factors for progression in atypical meningioma
Published in Journal of neurosurgery (01-11-2018)“…In patients with postoperative residual atypical meningiomas, by using volumetric instead of linear measurements in follow-up imaging studies, the authors…”
Get full text
Journal Article -
10
Combining mTOR inhibition with radiation improves antitumor activity in bladder cancer cells in vitro and in vivo: a novel strategy for treatment
Published in PloS one (17-06-2013)“…Radiation therapy for invasive bladder cancer allows for organ preservation but toxicity and local control remain problematic. As such, improving efficacy of…”
Get full text
Journal Article -
11
Prognostic factors in T1 bladder urothelial carcinoma: the value of recording millimetric depth of invasion, diameter of invasive carcinoma, and muscularis mucosa invasion
Published in Human pathology (2013)“…Summary pT1 bladder urothelial carcinomas represent a heterogeneous group of tumors with different biologic behaviors, and identifying the subset of tumors…”
Get full text
Journal Article -
12
A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer
Published in PloS one (08-02-2013)“…Two signalling molecules that are attractive for targeted therapy are the epidermal growth factor receptor (EGFR) and the peroxisome proliferator-activated…”
Get full text
Journal Article -
13
Correction: A Novel Mechanism of PPAR Gamma Induction via EGFR Signalling Constitutes Rational for Combination Therapy in Bladder Cancer
Published in PloS one (10-05-2013)“…With regards to the in vivo experiment, similar results were obtained with theUM-UC13 cell line where tumor weights were only significantly reduced in the…”
Get full text
Journal Article -
14
Feasibility and Impact of Immunohistochemistry-based Molecular Subtyping for Muscle-invasive Bladder Cancer in Patients Treated with Radiation-based Therapy
Published in European urology open science (Online) (01-11-2023)“…Molecular subtyping of muscle-invasive bladder cancer using an immunohistochemical three-antibody classifier is feasible and can be more easily used across…”
Get full text
Journal Article -
15
Expression of anaplastic lymphoma kinase in uveal melanoma
Published in The Pan-American journal of ophthalmology (01-01-2021)“…Purpose: The purpose of this study was to determine the expression of anaplastic lymphoma kinase (ALK) in uveal melanoma (UM) to evaluate its potential utility…”
Get full text
Journal Article -
16
Prostate-specific antigen bounce after high-dose-rate prostate brachytherapy and hypofractionated external beam radiotherapy
Published in Brachytherapy (01-09-2014)“…Abstract Purpose To report the frequency, timing, and magnitude of prostate-specific antigen (PSA) bounce (PB) in patients who received high-dose-rate (HDR)…”
Get full text
Journal Article -
17
Desulfovibrio vulgaris Hildenborough HydE and HydG interact with the HydA subunit of the [FeFe] hydrogenase
Published in Biotechnology letters (01-10-2008)“…HydE, HydF, and HydG participate in the synthesis of the complex di-iron center of [FeFe] hydrogenases. The hydE, hydF, hydG, hydA, and hydB genes of…”
Get full text
Journal Article -
18
Asparaginase production by a recombinant Pichia pastoris strain harbouring Saccharomyces cerevisiae ASP3 gene
Published in Enzyme and microbial technology (03-11-2006)“…The therapeutic enzyme asparaginase, which is used for the treatment of acute lymphoblastic leukaemia, is industrially produced by the bacteria Escherichia…”
Get full text
Journal Article -
19
Control of transcription in Schistosoma mansoni: Chromatin remodeling and other regulatory elements
Published in Acta tropica (01-11-2008)“…The platyhelminth parasite Schistosoma mansoni, the causative agent of schistosomiasis, is a dioecious parasite with a complex life cycle that includes two…”
Get full text
Journal Article -
20
Cloning of a protein arginine methyltransferase PRMT1 homologue from Schistosoma mansoni: Evidence for roles in nuclear receptor signaling and RNA metabolism
Published in Biochemical and biophysical research communications (07-10-2005)“…The most studied arginine methyltransferase is the type I enzyme, which catalyzes the transfer of an S-adenosyl- l-methionine to a broad spectrum of…”
Get full text
Journal Article