Search Results - "Jose, Roby J"
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Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and Atherosclerosis
Published in Arteriosclerosis, thrombosis, and vascular biology (01-03-2017)“…OBJECTIVE—Sclerostin (SOST) has been identified as an important regulator of bone formation; however, it has not been previously implicated in arterial…”
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Osteoprotegerin Deficiency Limits Angiotensin II–Induced Aortic Dilatation and Rupture in the Apolipoprotein E–Knockout Mouse
Published in Arteriosclerosis, thrombosis, and vascular biology (01-12-2014)“…OBJECTIVE—Mounting evidence links osteoprotegerin with cardiovascular disease. Elevated serum and aortic tissue osteoprotegerin are associated with the…”
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A Peptide Antagonist of Thrombospondin-1 Promotes Abdominal Aortic Aneurysm Progression in the Angiotensin II–Infused Apolipoprotein-E–Deficient Mouse
Published in Arteriosclerosis, thrombosis, and vascular biology (01-02-2015)“…OBJECTIVE—Interaction of the activating sequence in thrombospondin-1 (TSP-1) with the conserved sequence (leucine-serine-lysine-leucine [LSKL]) in the…”
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Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis
Published in Scientific reports (21-02-2017)“…Intraluminal thrombus is a consistent feature of human abdominal aortic aneurysm (AAA). Coagulation factor Xa (FXa) catalyses FII to thrombin (FIIa). We…”
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Everolimus Limits Aortic Aneurysm in the Apolipoprotein E–Deficient Mouse by Downregulating C-C Chemokine Receptor 2 Positive Monocytes
Published in Arteriosclerosis, thrombosis, and vascular biology (01-04-2013)“…OBJECTIVE—We aimed to determine the effect of mechanistic target of rapamycin inhibitor everolimus on abdominal aortic aneurysm within the angiotensin II…”
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Influence of apolipoprotein E, age and aortic site on calcium phosphate induced abdominal aortic aneurysm in mice
Published in Atherosclerosis (01-07-2014)“…Abstract Objective To assess relevant features of abdominal aortic aneurysms (AAA) induced by calcium phosphate within a mouse model. Specifically we…”
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Urocortin 2 is associated with abdominal aortic aneurysm and mediates anti-proliferative effects on vascular smooth muscle cells via corticotrophin releasing factor receptor 2
Published in Clinical science (1979) (01-04-2014)“…AAA (abdominal aortic aneurysm) is an important cause of sudden death in older adults, but there is no current effective drug therapy for this disease. The…”
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Development of a two-stage limb ischemia model to better simulate human peripheral artery disease
Published in Scientific reports (26-02-2020)“…Peripheral arterial disease (PAD) develops due to the narrowing or blockage of arteries supplying blood to the lower limbs. Surgical and endovascular…”
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Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth
Published in Clinical science (1979) (15-11-2019)“…The role of chronic inflammation in abdominal aortic aneurysm (AAA) is controversial. CD11c+ antigen-presenting cells (APCs) (dendritic cells (DCs)) have been…”
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Anionic nanoliposomes reduced atherosclerosis progression in Low Density Lipoprotein Receptor (LDLR) deficient mice fed a high fat diet
Published in Journal of cellular physiology (01-10-2018)“…Atherosclerosis is a systemic disease characterized by the deposition of cholesterol and inflammatory cells within the arterial wall. Removal of cholesterol…”
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Modulation of Kinin B2 Receptor Signaling Controls Aortic Dilatation and Rupture in the Angiotensin II–Infused Apolipoprotein E–Deficient Mouse
Published in Arteriosclerosis, thrombosis, and vascular biology (01-05-2016)“…OBJECTIVE—Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Activity of the local kallikrein–kinin system may be important in…”
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Herpes simplex virus-1–associated congenital cataract
Published in American journal of ophthalmology (01-08-2004)“…To report association of herpes simplex virus-type 1 (HSV-1) in four cases of congenital cataract. Prospective interventional case series. Four infants younger…”
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