Search Results - "Josan, Jatinder S."

Predictive features of ligand‐specific signaling through the estrogen receptor by Nwachukwu, Jerome C, Srinivasan, Sathish, Zheng, Yangfan, Wang, Song, Min, Jian, Dong, Chune, Liao, Zongquan, Nowak, Jason, Wright, Nicholas J, Houtman, René, Carlson, Kathryn E, Josan, Jatinder S, Elemento, Olivier, Katzenellenbogen, John A, Zhou, Hai‐Bing, Nettles, Kendall W

“…Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar…”
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Heterobivalent ligands target cell-surface receptor combinations in vivo by Xu, Liping, Josan, Jatinder S., Vagner, Josef, Caplan, Michael R., Hruby, Victor J., Mash, Eugene A., Lynch, Ronald M., Morse, David L., Gillies, Robert J.

“…A challenge in tumor targeting is to deliver payloads to cancers while sparing normal tissues. A limited number of antibodies appear to meet this challenge as…”
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Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors by Vagner, Josef, Xu, Liping, Handl, Heather L, Josan, Jatinder S, Morse, David L, Mash, Eugene A, Gillies, Robert J, Hruby, Victor J

“…Together we bind: A series of synthetic heterobivalent ligands containing a fragment of melanocyte stimulating hormone analogue MSH(7) and the δ‐opioid ligand…”
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Designer antiandrogens join the race against drug resistance by Josan, Jatinder S, Katzenellenbogen, John A

“…By using in silico models of the complexes formed by analogues of a cancer drug and its receptor, it may be possible to strategically redesign existing drugs…”
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Separation of stereoisomers of 7-oxa-bicyclo[2.2.1]heptene sulfonate (OBHS), a Selective Estrogen Receptor Modulator (SERM), via chiral stationary phases using SFC/UV and SFC/MS by Balasubramanyam, Penagaluri, Ashraf-Khorassani, Mehdi, Josan, Jatinder S.

“…The enantiomeric separation of a racemate of 7-oxa-bicyclo[2.2.1]heptene sulfonate (OBHS) derivatives, a Selective Estrogen Receptor Modulator (SERM), was…”
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Resazurin Live Cell Assay: Setup and Fine-Tuning for Reliable Cytotoxicity Results by Rodríguez-Corrales, José Á, Josan, Jatinder S

“…In vitro cytotoxicity tests allow for fast and inexpensive screening of drug efficacy prior to in vivo studies. The resazurin assay (commercialized as Alamar…”
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Development of Melanoma-Targeted Polymer Micelles by Conjugation of a Melanocortin 1 Receptor (MC1R) Specific Ligand by Barkey, Natalie M, Tafreshi, Narges K, Josan, Jatinder S, De Silva, Channa R, Sill, Kevin N, Hruby, Victor J, Gillies, Robert J, Morse, David L, Vagner, Josef

“…The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. Because of its high expression on the surface of…”
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Cell-Specific Targeting by Heterobivalent Ligands by Josan, Jatinder S, Handl, Heather L, Sankaranarayanan, Rajesh, Xu, Liping, Lynch, Ronald M, Vagner, Josef, Mash, Eugene A, Hruby, Victor J, Gillies, Robert J

“…Current cancer therapies exploit either differential metabolism or targeting to specific individual gene products that are overexpressed in aberrant cells. The…”
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Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ‑Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5 by Huynh, Amanda Shanks, Estrella, Veronica, Stark, Valerie E, Cohen, Allison S, Chen, Tingan, Casagni, Todd J, Josan, Jatinder S, Lloyd, Mark C, Johnson, Joseph, Kim, Jongphil, Hruby, Victor J, Vagner, Josef, Morse, David L

“…Fluorescence molecular imaging can be employed for the development of novel cancer targeting agents. Herein, we investigated the pharmacokinetics (PK) and…”
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Fluorescent and lanthanide labeling for ligand screens, assays, and imaging by Josan, Jatinder S, De Silva, Channa R, Yoo, Byunghee, Lynch, Ronald M, Pagel, Mark D, Vagner, Josef, Hruby, Victor J

“…The use of fluorescent (or luminescent) and metal contrast agents in high-throughput screens, in vitro assays, and molecular imaging procedures has rapidly…”
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Solid-Phase Synthetic Strategy and Bioevaluation of a Labeled δ-Opioid Receptor Ligand Dmt-Tic-Lys for In Vivo Imaging by Josan, Jatinder S, Morse, David L, Xu, Liping, Trissal, Maria, Baggett, Brenda, Davis, Peg, Vagner, Josef, Gillies, Robert J, Hruby, Victor J

“…A general solid-phase synthetic strategy is developed to prepare fluorescent and/or lanthanide-labeled derivatives of the δ-opioid receptor (δOR) ligand…”
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Synthesis and Evaluation of Bivalent NDP-α-MSH(7) Peptide Ligands for Binding to the Human Melanocortin Receptor 4 (hMC4R) by Handl, Heather L, Sankaranarayanan, Rajesh, Josan, Jatinder S, Vagner, Josef, Mash, Eugene A, Gillies, Robert J, Hruby, Victor J

“…We demonstrate the potential utility of multivalent ligands as targeting agents for cancer imaging or therapy by determining the binding of homobivalent…”
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Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors by Josan, Jatinder S., Vagner, Josef, Handl, Heather L., Sankaranarayanan, Rajesh, Gillies, Robert J., Hruby, Victor J.

“…Heteromultivalency provides a route to increase binding avidity and to high specificity when compared to monovalent ligands. The enhanced specificity can…”
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Synthesis, receptor binding, and activation studies of N(1)-alkyl- l-histidine containing thyrotropin-releasing hormone (TRH) analogues by Kaur, Navneet, Monga, Vikramdeep, Josan, Jatinder S., Lu, Xinping, Gershengorn, Marvin C., Jain, Rahul

“…Thyrotropin-releasing hormone (TRH) analogues in which the N(1)-position of the imidazole ring of the centrally placed histidine residue is substituted with…”
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Heterobivalent ligands crosslink multiple cell-surface receptors--a step towards personal medicine by Josan, Jatinder S, Sankaranarayanan, Rajesh, Handl, Heather L, Fernandes, Steve, Xu, Liping, Vagner, Josef, Gillies, Robert J, Hruby, Victor J

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MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression by Christenson, Jessica L., Butterfield, Kiel T., Spoelstra, Nicole S., Norris, John D., Josan, Jatinder S., Pollock, Julie A., McDonnell, Donald P., Katzenellenbogen, Benita S., Katzenellenbogen, John A., Richer, Jennifer K.

“…Triple-negative breast cancer (TNBC) has a faster rate of metastasis compared to other breast cancer subtypes, and no effective targeted therapies are…”
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Abstract 1805: Development of a selective androgen receptor degrader (SARD) for treatment of castration-resistant prostate cancer by Yao, ZhongKe, Wardell, Suzanne, Spasojevic, Ivan, Norris, John, Katzenellenbogen, John, McDonnell, Donald, Josan, Jatinder S.

“…Current treatments for prostate cancer are centered on blocking androgen-signaling axis, which is the target of several clinical androgen receptor (AR)…”
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Tumor Targeting, Pharmacokinetics and Biodistribution of a Near Infrared Fluorescent-labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5 by Huynh, Amanda Shanks, Estrella, Veronica, Stark, Valerie E., Cohen, Allison S., Chen, Tingan, Casagni, Todd J., Josan, Jatinder S., Lloyd, Mark C., Johnson, Joseph, Hruby, Victor J., Vagner, Josef, Morse, David L.

“…Fluorescence molecular imaging can be employed for the development of novel cancer targeting agents. Herein, we investigated the pharmacokinetics (PK),…”
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Modulation of Cell Specific Signaling by Cross‐Linking Receptors with Multivalent Ligands by Weber, Craig S, Vagner, Josef, Josan, Jatinder S, Gillies, Robert, Lynch, Ronald M

“…Connecting two ligands with a flexible linker produces a molecule with potential to cross‐link multiple receptors on a cells surface. We previously showed that…”
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Synthesis and Evaluation of Bivalent NDP-¿-MSH(7) Peptide Ligands for Binding to the Human Melanocortin Receptor 4 (hMC4R) by Handl, Heather L, Sankaranarayanan, Rajesh, Josan, Jatinder S, Vagner, Josef

“…We demonstrate the potential utility of multivalent ligands as targeting agents for cancer imaging or therapy by determining the binding of homobivalent…”
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