Evolution of pediatric pharmaceutical forms for treatment of Hansen's disease (leprosy)

Leprosy is a neglected, infectious, granulomatous and chronic disease caused by the pathological agent . The course of the disease is more aggressive in patients under 15 years of age, but the current treatment offered worldwide consists of solid forms, by the combination of antibiotics such as rifa...

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Bibliographic Details
Published in:	Expert opinion on therapeutic patents Vol. 33; no. 1; p. 1
Main Authors:	da Silva Santos, Jocimar, da Costa Alves, Franciely, José Dos Santos Júnior, Efraim, Soares Sobrinho, José Lamartine, de La Roca Soares, Mônica Felts
Format:	Journal Article
Language:	English
Published:	England 02-01-2023
Subjects:	Child Humans Leprostatic Agents - therapeutic use Leprosy - drug therapy Leprosy - microbiology Patents as Topic Pharmaceutical Preparations Rifampin - therapeutic use rifampicin Pharmaceutical technology dapsone clofazimine routes of drug administration
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Summary:	Leprosy is a neglected, infectious, granulomatous and chronic disease caused by the pathological agent . The course of the disease is more aggressive in patients under 15 years of age, but the current treatment offered worldwide consists of solid forms, by the combination of antibiotics such as rifampicin, clofazimine and dapsone. This represents results in lack of adherence in pediatric patients and drug therapy failure, although numerous formulations and technologies have already been developed. This study aims to analyze the technological evolution of the pharmaceutical treatment of leprosy, aimed at children. A review of patents around the world was conducted to look for technical and clinical aspects of formulations and devices. Innovative formulations for pediatric patients were classified according to the routes of administration as oral, inhalable, injectable and transdermal. The formulations were organized as alternatives for pediatric therapy, taking into account the physicochemical aspects of drugs and the physiological aspects of pediatric patients. Among the difficulties for the patented formulations to reach the market, of special note is the low stability of the physicochemical characteristics of the drugs. Optimization of formulations would favor the pediatric treatment of leprosy, aiming at therapeutic success.
ISSN:	1744-7674
DOI:	10.1080/13543776.2023.2178301