Search Results - "José Ángel Díaz Arias"

Prognostic Stratification of Multiple Myeloma Using Clinicogenomic Models: Validation and Performance Analysis of the IAC‐50 Model by Mosquera Orgueira, Adrián, González Pérez, Marta Sonia, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, Mateos, María‐Victoria

“…A growing need to evaluate risk‐adapted treatments in multiple myeloma (MM) exists. Several clinical and molecular scores have been developed in the last…”
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Time to Treatment Prediction in Chronic Lymphocytic Leukemia Based on New Transcriptional Patterns by Mosquera Orgueira, Adrián, Antelo Rodríguez, Beatriz, Alonso Vence, Natalia, Bendaña López, Ángeles, Díaz Arias, José Ángel, Díaz Varela, Nicolás, González Pérez, Marta Sonia, Pérez Encinas, Manuel Mateo, Bello López, José Luis

“…Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative syndrome in western countries. CLL evolution is frequently indolent, and treatment…”
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Survival prediction and treatment optimization of multiple myeloma patients using machine-learning models based on clinical and gene expression data by Mosquera Orgueira, Adrián, González Pérez, Marta Sonia, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuín Blanco, Aitor, Bao Pérez, Laura, Peleteiro Raíndo, Andrés, Cid López, Miguel, Pérez Encinas, Manuel Mateo, Bello López, José Luis, Mateos Manteca, Maria Victoria

“…Multiple myeloma (MM) remains mostly an incurable disease with a heterogeneous clinical evolution. Despite the availability of several prognostic scores,…”
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Corrigendum: Evaluation of the Stellae-123 prognostic gene expression signature in acute myeloid leukemia by Mosquera Orgueira, Adrián, Peleteiro Raíndo, Andrés, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, López Riñón, Mónica, Cerchione, Claudio, de la Fuente Burguera, Adolfo, González Pérez, Marta Sonia, Martinelli, Giovanni, Montesinos Fernández, Pau, Pérez Encinas, Manuel Mateo

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New Recurrent Structural Aberrations in the Genome of Chronic Lymphocytic Leukemia Based on Exome-Sequencing Data by Mosquera Orgueira, Adrián, Antelo Rodríguez, Beatriz, Díaz Arias, José Ángel, González Pérez, Marta Sonia, Bello López, José Luis

“…Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative syndrome in Western countries, and it is characterized by recurrent large genomic…”
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Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling by Mosquera Orgueira, Adrián, Díaz Arias, José Ángel, Cid López, Miguel, Peleteiro Raíndo, Andrés, Antelo Rodríguez, Beatriz, Aliste Santos, Carlos, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuín Blanco, Aitor, Bao Pérez, Laura, González Pérez, Marta Sonia, Pérez Encinas, Manuel Mateo, Fraga Rodríguez, Máximo Francisco, Bello López, José Luis

“…Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology…”
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The association of germline variants with chronic lymphocytic leukemia outcome suggests the implication of novel genes and pathways in clinical evolution by Mosquera Orgueira, Adrián, Antelo Rodríguez, Beatriz, Alonso Vence, Natalia, Díaz Arias, José Ángel, Díaz Varela, Nicolás, Pérez Encinas, Manuel Mateo, Allegue Toscano, Catarina, Goiricelaya Seco, Elena María, Carracedo Álvarez, Ángel, Bello López, José Luis

“…Chronic Lymphocytic Leukemia (CLL) is the most frequent lymphoproliferative disorder in western countries and is characterized by a remarkable clinical…”
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Correction: Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia by Mosquera Orgueira, Adrián, Peleteiro Raíndo, Andrés, Cid López, Miguel, Antelo Rodríguez, Beatriz, Díaz Arias, José Ángel, Ferreiro Ferro, Roi, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuín Blanco, Aitor, Bao Pérez, Laura, Melero Valentín, Paula, Sonia González Pérez, Marta, Cerchione, Claudio, Martinelli, Giovanni, Montesinos Fernández, Pau, Mateo Pérez Encinas, Manuel, Luis Bello López, José

“…[This corrects the article DOI: 10.1371/journal.pone.0247093.]…”
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De novo drug design through artificial intelligence: an introduction by Crucitti, Davide, Pérez Míguez, Carlos, Díaz Arias, José Ángel, Fernandez Prada, Diego Beltrán, Mosquera Orgueira, Adrián

“…Developing new drugs is a complex and formidable challenge, intensified by rapidly evolving global health needs. De novo drug design is a promising strategy to…”
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Detection of Rare Germline Variants in the Genomes of Patients with B-Cell Neoplasms by Mosquera Orgueira, Adrián, Cid López, Miguel, Peleteiro Raíndo, Andrés, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, Bao Pérez, Laura, Alonso Vence, Natalia, Bendaña López, Ángeles, Abuin Blanco, Aitor, Melero Valentín, Paula, Ferreiro Ferro, Roi, Aliste Santos, Carlos, Fraga Rodríguez, Máximo Francisco, González Pérez, Marta Sonia, Pérez Encinas, Manuel Mateo, Bello López, José Luis

“…There is growing evidence indicating the implication of germline variation in cancer predisposition and prognostication. Here, we describe an analysis of…”
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Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling by Mosquera Orgueira, Adrián, Krali, Olga, Pérez Míguez, Carlos, Peleteiro Raíndo, Andrés, Díaz Arias, José Ángel, González Pérez, Marta Sonia, Pérez Encinas, Manuel Mateo, Fernández Sanmartín, Manuel, Sinnet, Daniel, Heyman, Mats, Lönnerholm, Gudmar, Norén-Nyström, Ulrika, Schmiegelow, Kjeld, Nordlund, Jessica

“…Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatment outcomes, relapses still pose…”
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A prognostic model based on gene expression parameters predicts a better response to bortezomib-containing immunochemotherapy in diffuse large B-cell lymphoma by Mosquera Orgueira, Adrián, Díaz Arías, Jose Ángel, Serrano Martín, Rocio, Portela Piñeiro, Victor, Cid López, Miguel, Peleteiro Raíndo, Andrés, Bao Pérez, Laura, González Pérez, Marta Sonia, Pérez Encinas, Manuel Mateo, Fraga Rodríguez, Máximo Francisco, Vallejo Llamas, Juan Carlos, Bello López, José Luis

“…Diffuse Large B-cell Lymphoma (DLBCL) is the most common type of aggressive lymphoma. Approximately 60% of fit patients achieve curation with…”
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Prognostic Stratification of Diffuse Large B‐cell Lymphoma Using Clinico‐genomic Models: Validation and Improvement of the LymForest‐25 Model by Mosquera Orgueira, Adrián, Díaz Arías, Jose Ángel, Cid López, Miguel, Peleteiro Raíndo, Andrés, López García, Alberto, Abal García, Rosanna, González Pérez, Marta Sonia, Antelo Rodríguez, Beatriz, Aliste Santos, Carlos, Pérez Encinas, Manuel Mateo, Fraga Rodríguez, Máximo Francisco, Bello López, José Luis

“…Diffuse large B‐cell lymphoma (DLBCL) is the most common type of non‐Hodgkin lymphoma. Despite notable therapeutic advances in the last decades, 30%–40% of…”
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Correction: Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia by Adrián Mosquera Orgueira, Andrés Peleteiro Raíndo, Miguel Cid López, Beatriz Antelo Rodríguez, José Ángel Díaz Arias, Roi Ferreiro Ferro, Natalia Alonso Vence, Ángeles Bendaña López, Aitor Abuín Blanco, Laura Bao Pérez, Paula Melero Valentín, Marta Sonia González Pérez, Claudio Cerchione, Giovanni Martinelli, Pau Montesinos Fernández, Manuel Mateo Pérez Encinas, José Luis Bello López

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Novel Mutation Hotspots within Non-Coding Regulatory Regions of the Chronic Lymphocytic Leukemia Genome by Mosquera Orgueira, Adrián, Rodríguez Antelo, Beatriz, Díaz Arias, José Ángel, Díaz Varela, Nicolás, Alonso Vence, Natalia, González Pérez, Marta Sonia, Bello López, José Luis

“…Mutations in non-coding DNA regions are increasingly recognized as cancer drivers. These mutations can modify gene expression in cis or by inducing high-order…”
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Personalized Survival Prediction of Patients With Acute Myeloblastic Leukemia Using Gene Expression Profiling by Mosquera Orgueira, Adrián, Peleteiro Raíndo, Andrés, Cid López, Miguel, Díaz Arias, José Ángel, González Pérez, Marta Sonia, Antelo Rodríguez, Beatriz, Alonso Vence, Natalia, Bao Pérez, Laura, Ferreiro Ferro, Roi, Albors Ferreiro, Manuel, Abuín Blanco, Aitor, Fontanes Trabazo, Emilia, Cerchione, Claudio, Martinnelli, Giovanni, Montesinos Fernández, Pau, Mateo Pérez Encinas, Manuel, Luis Bello López, José

“…Acute Myeloid Leukemia (AML) is a heterogeneous neoplasm characterized by cytogenetic and molecular alterations that drive patient prognosis. Currently…”
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Evaluation of the Stellae-123 prognostic gene expression signature in acute myeloid leukemia by Mosquera Orgueira, Adrián, Peleteiro Raíndo, Andrés, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, López Riñón, Mónica, Cerchione, Claudio, de la Fuente Burguera, Adolfo, González Pérez, Marta Sonia, Martinelli, Giovanni, Montesinos Fernández, Pau, Pérez Encinas, Manuel Mateo

“…Risk stratification in acute myeloid leukemia (AML) has been extensively improved thanks to the incorporation of recurrent cytogenomic alterations into risk…”
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Personally Tailored Survival Prediction of Patients With Follicular Lymphoma Using Machine Learning Transcriptome-Based Models by Mosquera Orgueira, Adrián, Cid López, Miguel, Peleteiro Raíndo, Andrés, Abuín Blanco, Aitor, Díaz Arias, Jose Ángel, González Pérez, Marta Sonia, Antelo Rodríguez, Beatriz, Bao Pérez, Laura, Ferreiro Ferro, Roi, Aliste Santos, Carlos, Pérez Encinas, Manuel Mateo, Fraga Rodríguez, Máximo Francisco, Cerchione, Claudio, Mozas, Pablo, Bello López, José Luis

“…Follicular Lymphoma (FL) has a 10-year mortality rate of 20%, and this is mostly related to lymphoma progression and transformation to higher grades. In the…”
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A Three-Gene Expression Signature Identifies a Cluster of Patients with Short Survival in Chronic Lymphocytic Leukemia by Díaz Varela, Nicolás, Díaz Arias, José Ángel, Antelo Rodríguez, Beatriz, Mosquera Orgueira, Adrián, Bello López, José Luis

“…Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by its heterogeneous clinical evolution. Despite the discovery of the most…”
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Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes by Mosquera Orgueira, Adrián, Ferreiro Ferro, Roi, Díaz Arias, José Ángel, Aliste Santos, Carlos, Antelo Rodríguez, Beatriz, Bao Pérez, Laura, Alonso Vence, Natalia, Bendaña López, Ággeles, Abuin Blanco, Aitor, Melero Valentín, Paula, Peleteiro Raindo, And Res, Cid López, Miguel, Pérez Encinas, Manuel Mateo, González Pérez, Marta Sonia, Fraga Rodríguez, Máximo Francisco, Bello López, José Luis

“…B-cell lymphoproliferative disorders exhibit a diverse spectrum of diagnostic entities with heterogeneous behaviour. Multiple efforts have focused on the…”
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