Search Results - "Joruiz, Sebastien M."

p53 Isoforms: Key Regulators of the Cell Fate Decision by Joruiz, Sebastien M, Bourdon, Jean-Christophe

“…It is poorly understood how a single protein, p53, can be responsive to so many stress signals and orchestrates very diverse cell responses to maintain/restore…”
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Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence by Joruiz, Sebastien M., Von Muhlinen, Natalia, Horikawa, Izumi, Gilbert, Mark R., Harris, Curtis C.

“…Despite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore, exploring the…”
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Germline variant affecting p53β isoforms predisposes to familial cancer by Schubert, Stephanie A., Ruano, Dina, Joruiz, Sebastien M., Stroosma, Jordy, Glavak, Nikolina, Montali, Anna, Pinto, Lia M., Rodríguez-Girondo, Mar, Barge-Schaapveld, Daniela Q. C. M., Nielsen, Maartje, van Nesselrooij, Bernadette P. M., Mensenkamp, Arjen R., van Leerdam, Monique E., Sharp, Thomas H., Morreau, Hans, Bourdon, Jean-Christophe, de Miranda, Noel F. C. C., van Wezel, Tom

“…Germline and somatic TP53 variants play a crucial role during tumorigenesis. However, genetic variations that solely affect the alternatively spliced p53…”
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The [DELTA]133p53 Isoforms, Tuners of the p53 Pathway by Joruiz, Sebastien M, Beck, Jessica A, Horikawa, Izumi, Harris, Curtis C

“…TP53, the most frequently mutated gene in human cancers, has a key role in the maintenance of the genetic stability and, thus, in preventing tumor development…”
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Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development by Kazantseva, Marina, Eiholzer, Ramona A, Mehta, Sunali, Taha, Ahmad, Bowie, Sara, Roth, Imogen, Zhou, Jean, Joruiz, Sebastien M, Royds, Janice A, Hung, Noelyn A, Slatter, Tania L, Braithwaite, Antony W

“…As tumor protein 53 (p53) isoforms have tumor‐promoting, migration, and inflammatory properties, this study investigated whether p53 isoforms contributed to…”
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The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer by Kazantseva, Marina, Mehta, Sunali, Eiholzer, Ramona A., Gimenez, Gregory, Bowie, Sara, Campbell, Hamish, Reily-Bell, Ashley L., Roth, Imogen, Ray, Sankalita, Drummond, Catherine J., Reid, Glen, Joruiz, Sebastien M., Wiles, Anna, Morrin, Helen R., Reader, Karen L., Hung, Noelyn A., Baird, Margaret A., Slatter, Tania L., Braithwaite, Antony W.

“…Prostate cancer is the second most common cancer in men, for which there are no reliable biomarkers or targeted therapies. Here we demonstrate that elevated…”
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The Δ133p53 Isoforms, Tuners of the p53 Pathway by Joruiz, Sebastien M., Beck, Jessica A., Horikawa, Izumi, Harris, Curtis C.

“…The TP53 gene is a critical tumor suppressor and key determinant of cell fate which regulates numerous cellular functions including DNA repair, cell cycle…”
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TP53 drives invasion through expression of its Δ133p53β variant by Gadea, Gilles, Arsic, Nikola, Fernandes, Kenneth, Diot, Alexandra, Joruiz, Sébastien M, Abdallah, Samer, Meuray, Valerie, Vinot, Stéphanie, Anguille, Christelle, Remenyi, Judit, Khoury, Marie P, Quinlan, Philip R, Purdie, Colin A, Jordan, Lee B, Fuller-Pace, Frances V, de Toledo, Marion, Cren, Maïlys, Thompson, Alastair M, Bourdon, Jean-Christophe, Roux, Pierre

“…is conventionally thought to prevent cancer formation and progression to metastasis, while mutant has transforming activities. However, in the clinic, mutation…”
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