Search Results - "Jornvall, Hans"

Biological activity versus physiological function of proinsulin C-peptide by Landreh, Michael, Jörnvall, Hans

“…Proinsulin C-peptide (C-peptide) has drawn much research attention. Even if the peptide has turned out not to be important in the treatment of diabetes, every…”
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MDR-alcohol dehydrogenases by Jornvall, H

“…Close to 80 years of research have brought MDR alcohol dehydrogenases (ADHs) from unknown molecular concepts to molecules known in exact detail regarding…”
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Protective Effects of Dimethyl Sulfoxide on Labile Protein Interactions during Electrospray Ionization by Landreh, Michael, Alvelius, Gunvor, Johansson, Jan, Jörnvall, Hans

“…Electrospray ionization mass spectrometry is a valuable tool to probe noncovalent interactions. However, the integrity of the interactions in the gas-phase is…”
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Specific Chaperones and Regulatory Domains in Control of Amyloid Formation by Landreh, Michael, Rising, Anna, Presto, Jenny, Jörnvall, Hans, Johansson, Jan

“…Many proteins can form amyloid-like fibrils in vitro, but only about 30 amyloids are linked to disease, whereas some proteins form physiological amyloid-like…”
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C-peptide evolution: Generation from few structural restrictions of bioactivities not necessarily functional by Landreh, Michael, Jörnvall, Hans

“…•C-peptide lacks both disease-associated mutations and short-term loss-of-functions.•Insulin requires only few C-peptide structural features in their…”
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Separate Molecular Determinants in Amyloidogenic and Antimicrobial Peptides by Landreh, Michael, Johansson, Jan, Jörnvall, Hans

“…Several amyloid-forming and antimicrobial peptides (AMYs and AMPs) have the ability to bind to and damage cell membranes. In addition, some AMYs possess…”
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Superfamilies SDR and MDR: From early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities by Jörnvall, Hans, Hedlund, Joel, Bergman, Tomas, Oppermann, Udo, Persson, Bengt

“…Two large gene and protein superfamilies, SDR and MDR (short- and medium-chain dehydrogenases/reductases), were originally defined from analysis of alcohol and…”
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Alcohol dehydrogenase, SDR and MDR structural stages, present update and altered era by Jörnvall, Hans, Landreh, Michael, Östberg, Linus J.

“…•Molecular research on ADH since ∼50years.•Updates on numbers of known ADH, MDR and SDR forms.•Constant and variable forms, with apparent restrictions also in…”
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The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1–23) and amyloid β-peptide (Aβ1–40): Implications for Bri2 effects on processing of amyloid precursor protein and Aβ aggregation by Peng, Siwei, Fitzen, Michael, Jörnvall, Hans, Johansson, Jan

“…In Alzheimer’s disease the amyloid β-peptide (Aβ) aggregates in brain tissue and arteries. Aβ is proteolytically cleaved out from amyloid precursor protein…”
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N-terminal segment of proinsulin C-peptide active in insulin interaction/desaggregation by Nerelius, Charlotte, Alvelius, Gunvor, Jörnvall, Hans

“…► C-peptide fragment interactions with insulin involve the N-terminal part with Glu11. ► Insulin-interacting and membrane-interacting segments of C-peptide are…”
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Insulin, islet amyloid polypeptide and C-peptide interactions evaluated by mass spectrometric analysis by Landreh, Michael, Alvelius, Gunvor, Johansson, Jan, Jörnvall, Hans

“…RATIONALE Insulin, islet amyloid polypeptide (IAPP), and the C‐peptide part of proinsulin are co‐secreted from the pancreatic beta cell granules. IAPP…”
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A subdivided molecular architecture with separate features and stepwise emergence among proinsulin C-peptides by Landreh, Michael, Östberg, Linus J., Jörnvall, Hans

“…[Display omitted] •Segmental sub-division of proinsulin C-peptide structure, but variable in number and residues.•Compatible with step-wise evolution, with…”
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New developments in protein structure–function analysis by MS and use of hydrogen–deuterium exchange microfluidics by Landreh, Michael, Astorga‐Wells, Juan, Johansson, Jan, Bergman, Tomas, Jörnvall, Hans

“…The study of protein structure and function has evolved to become a leading discipline in the biophysical sciences. Although it is not yet possible to…”
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Integrated Sample Preparation and MALDI Mass Spectrometry on a Microfluidic Compact Disk by Gustafsson, Magnus, Hirschberg, Daniel, Palmberg, Carina, Jörnvall, Hans, Bergman, Tomas

“…High-throughput microfluidic processing of protein digests integrated with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry on a compact…”
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Back Cover: Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains (ChemBioChem 12/2015) by Otikovs, Martins, Chen, Gefei, Nordling, Kerstin, Landreh, Michael, Meng, Qing, Jörnvall, Hans, Kronqvist, Nina, Rising, Anna, Johansson, Jan, Jaudzems, Kristaps

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A Membrane Cell for On-line Hydrogen/Deuterium Exchange to Study Protein Folding and Protein-Protein Interactions by Mass Spectrometry by Astorga-Wells, Juan, Landreh, Michael, Johansson, Jan, Bergman, Tomas, Jörnvall, Hans

“…A membrane cell for hydrogen and deuterium exchange on-line with mass spectrometry has been developed to monitor protein-protein interactions and protein…”
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Proinsulin C-peptide interaction with protein tyrosine phosphatase 1B demonstrated with a labeling reaction by Jägerbrink, Theres, Lindahl, Emma, Shafqat, Jawed, Jörnvall, Hans

“…Based on nickel-catalyzed cross-labeling where binding partners become biotinylated, we have studied molecular interactions with an N-terminally fused GGH-tag…”
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Antimicrobial components of the neonatal gut affected upon colonization by KAI-LARSEN, Ylva, BERGSSON, Gudmundur, GUDMUNDSSON, Gudmundur H, PRINTZ, Gordana, JÖRNVALL, Hans, MARCHINI, Giovanna, AGERBERTH, Birgitta

“…Antimicrobial peptides (AMP) produced throughout our body are important effectors in the defense barrier of innate immunity. Here, we have analyzed…”
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Antibacterial Components in Bronchoalveolar Lavage Fluid from Healthy Individuals and Sarcoidosis Patients by AGERBERTH, BIRGITTA, GRUNEWALD, JOHAN, CASTANOS-VELEZ, ESMERALDA, OLSSON, BERIT, JORNVALL, HANS, WIGZELL, HANS, EKLUND, ANDERS, GUDMUNDSSON, GUDMUNDUR H

“…Antibacterial peptides and proteins are an integral part of the epithelial defense barrier that provides immediate protection against bacterial invasion. In…”
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A Microfluidic Electrocapture Device in Sample Preparation for Protein Analysis by MALDI Mass Spectrometry by Astorga-Wells, Juan, Jörnvall, Hans, Bergman, Tomas

“…The design and operation of a microfluidic device for sample preparation in MALDI mass spectrometry of peptides and proteins is described. It is particularly…”
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