Search Results - "Jorkasky, D K"

Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin by Sheth, S B, DiCicco, R A, Hursting, M J, Montague, T, Jorkasky, D K

“…The effects of argatroban, a direct thrombin inhibitor, on the International Normalized Ratio (INR), activated partial thromboplastin time (aPTT) and…”
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Systemic exposure to rosiglitazone is unaltered by food by FREED, M. I, ALLEN, A, JORKASKY, D. K, DICICCO, R. A

“…To evaluate the effect of food on the bioavailability and pharmacokinetics of the insulin sensitizer rosiglitazone. In a randomized, open-label,…”
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Use of topical corticosteroid pretreatment to reduce the incidence and severity of skin reactions associated with testosterone transdermal therapy by Wilson, Douglas E., Kaidbey, Kays, Boike, Steven C., Jorkasky, Diane K.

“…Local skin reactions at the application site are the most common adverse events associated with the testosterone transdermal delivery (TTD) systems used to…”
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Urinary excretion of 6β-hydroxycortisol as an in vivo marker for CYP3A induction: Applications and recommendations by Kovacs, Steven J., Martin, David E., Everitt, Daniel E., Patterson, Scott D., Jorkasky, Diane K.

“…Objective To evaluate the usefulness of 6β‐hydroxycortisol as a screen for CYP3A induction in early‐phase drug development. Methods Five groups of 12 healthy…”
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Lack of Effect of Rosiglitazone on the Pharmacokinetics of Oral Contraceptives in Healthy Female Volunteers by Inglis, Anne Marie L., Miller, Ann K., Culkin, Kathleen Thompson, Finnerty, Dana, Patterson, Scott D., Jorkasky, Diane K., Freed, Martin I.

“…The effect of rosiglitazone (Avandia® [BRL 49653C]) on the pharmacokinetics of ethinylestmdiol and norethindrone was evaluated after repeat dosing of…”
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Rosiglitazone Has No Clinically Significant Effect on Nifedipine Pharmacokinetics by Harris, Robert Z., Inglis, Anne Marie L., Miller, Ann K., Thompson, Kathleen A., Finnerty, Dana, Patterson, Scott, Jorkasky, Diane K., Freed, Martin I.

“…To examine the effects of repeat oral dosing of rosiglitazone on the pharmacokinetics of nifedipine, a prototype CYP3A4 substrate, a randomized, open‐label,…”
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The Pharmacokinetics, Antigenicity, and Fusion-Inhibition Activity of RSHZ19, a Humanized Monoclonal Antibody to Respiratory Syncytial Virus, in Healthy Volunteers by Everitt, Daniel E., Davis, Charles B., Thompson, Kathleen, DiCicco, Robert, Ilson, Bernard, Demuth, Sandra G., Herzyk, Danuta J., Jorkasky, Diane K.

“…Single ascending doses of RSHZ19 (also known as SB 209763), a humanized monoclonal antibody (MAb) directed to the fusion protein of respiratory syncytial…”
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Effect of fluconazole on the pharmacokinetics of eprosartan and losartan in healthy male volunteers by Kazierad, David J., Martin, David E., Blum, Robert A., Tenero, David M., Ilson, Bernard, Boike, Steven C., Etheredge, Rickey, Jorkasky, Diane K.

“…Objective To investigate the effect of steady‐state fluconazole administration on the disposition of eprosartan, losartan, and E‐3174. Methods Sixteen healthy…”
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Effect of a new synthetic hexapeptide to selectively stimulate growth hormone release in healthy human subjects by Ilson, B E, Jorkasky, D K, Curnow, R T, Stote, R M

“…Growth hormone-releasing peptide (GHRP, SK&F 110679) is a hexapeptide (His-DTrp-Ala-Trp-DPhe-LysNH2) that selectively stimulates the release of growth hormone…”
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Lack of effect of eprosartan on the single dose pharmacokinetics of orally administered digoxin in healthy male volunteers by Martin, D. E., Tompson, D., Boike, S. C., Tenero, D., Ilson, B., Citerone, D., Jorkasky, D. K.

“…Aims To study the effect of eprosartan, a nonbiphenyl tetrazole angiotensin II receptor antagonist, on digoxin pharmacokinetics in a randomized, open‐label,…”
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Long-term renal function in kidney donors: a comparison of donors and their siblings by Williams, S L, Oler, J, Jorkasky, D K

“…To assess the effects of unilateral nephrectomy, we evaluated renal function and hypertension in kidney donors who had had nephrectomies 10 years ago or more…”
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Safety and Pharmacokinetics of an Intramuscular Monoclonal Antibody (SB 209763) against Respiratory Syncytial Virus (RSV) in Infants and Young Children at Risk for Severe RSV Disease by MEISSNER, H. C, GROOTHUIS, J. R, NICHOLS, A. I, JORKASKY, D. K, EVERITT, D. E, THOMPSON, K. A, RODRIGUEZ, W. J, WELLIVER, R. C, HOGG, G, GRAY, P. H, LOH, R, SIMOES, E. A. F, SLY, P, MILLER, A. K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Renal allografts: prospective analysis of Doppler sonography by Allen, K S, Jorkasky, D K, Arger, P H, Velchik, M G, Grumbach, K, Coleman, B G, Mintz, M C, Betsch, S E, Perloff, L J

“…Fifty-six consecutively transplanted renal allografts were prospectively evaluated with serial Doppler sonographic examinations. Thirty-eight episodes of…”
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Cardiovascular effects of i.v. granisetron at two administration rates and of ondansetron in healthy adults by Boike, SC, Ilson, B, Zariffa, N, Jorkasky, DK

“…The cardiovascular effects of granisetron given as a 30-second i.v. bolus dose and of granisetron and ondansetron given by currently recommended methods were…”
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What does the clinician want to know from the toxicologist? by Jorkasky, Diane K

“…The integration of the toxicological evaluation of a new drug with its pharmokinetics and pharmacological profiling within and across species will provide more…”
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Assessment of the Potential Pharmacokinetic and Pharmacodynamic Interactions between Erythromycin and Argatroban by Tran, Jonathan Q., Di Cicco, Robert A., Sheth, Sunita B., Tucci, Marcella, Peng, Lana, Jorkasky, Diane K., Hursting, Marcie J., Benincosa, Lisa J.

“…Argatroban, a direct thrombin inhibitor, is metabolized in vitro by CYP3A4/5 and therefore may be susceptible to clinically relevant CYP3A drug interactions…”
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The Effect of Low-Dose Cimetidine (200 mg Twice Daily) on the Pharmacokinetics of Theophylline by Nix, David E., Di Cicco, Robert A., Miller, Ann K., Boyle, Duane A., Boike, Steven C., Zariffa, Nevine, Jorkasky, Diane K., Schentag, Jerome J.

“…The potential for nonprescription cimetidine (200 mg twice daily) to affect the pharmacokinetics of sustained‐release (SR) theophylline was assessed in 26 male…”
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Pharmacokinetics and Protein Binding of Eprosartan in Hemodialysis-Dependent Patients with End-Stage Renal Disease by Kovacs, Steven J., Tenero, David M., Martin, David E., Ilson, Bernard E., Jorkasky, Diane K.

“…Study Objectives. To compare eprosartan pharmacokinetics in hemodialysis patients and in volunteers with normal renal function, and to determine the effect of…”
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Paroxetine does not affect the cardiac safety and pharmacokinetics of terfenadine in healthy adult men by MARTIN, D. E, ZUSSMAN, B. D, EVERITT, D. E, BENINCOSA, L. J, ETHEREDGE, R. C, JORKASKY, D. K

“…Potent CYP3A4 inhibitors such as ketoconazole can cause dangerous increases in plasma concentrations of the H-1 antagonist terfenadine. In light of recent…”
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A Dose Proportionality Study of Eprosartan in Healthy Male Volunteers by Chapelsky, Martha C., Martin, David E., Tenero, David M., Ilson, Bernard E., Boike, Steven C., Etheredge, Rickey, Jorkasky, Diane K.

“…The present study investigated the proportionality of exposure after single oral doses of 100, 200, 400, and 800 mg of eprosartan, a nonpeptide, nonbiphenyl…”
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