Search Results - "Jorgensen, A. L."

HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review by Yip, V L, Marson, A G, Jorgensen, A L, Pirmohamed, M, Alfirevic, A

“…Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has…”
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SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink by Carr, D F, O'Meara, H, Jorgensen, A L, Campbell, J, Hobbs, M, McCann, G, van Staa, T, Pirmohamed, M

“…This study aimed to determine whether patients with statin‐induced myopathy could be identified using the United Kingdom Clinical Practice Research Datalink,…”
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Serum and blister‐fluid elevation and decreased epidermal content of high‐mobility group box 1 protein in drug‐induced Stevens–Johnson syndrome/toxic epidermal necrolysis by Carr, D.F., Wang, C.‐W., Bellón, T., Ressel, L., Nwikue, G., Shrivastava, V., Bergfeld, W., Jorgensen, A.L., Chung, W.‐H., Pirmohamed, M.

“…Summary Background High‐mobility group box 1 (HMGB1) is a damage‐associated molecular‐pattern protein. Stevens–Johnson syndrome (SJS)/toxic epidermal…”
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Biomarker-guided trials: challenges in practice by M, Antoniou, Kolamunnage-Dona, R., J, Wason, R, Bathia, C, Billingham, JM, Bliss, LC, Brown, A, Gillman, J, Paul, AL, Jorgensen

“…Biomarker-guided trials have drawn considerable attention as they promise to lead to improvements in the benefit-risk ratio of treatments and enhanced…”
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Cervical stitch (cerclage) for preventing pregnancy loss : individual patient data meta-analysis by JORGENSEN, A. L, ALFIREVIC, Z., TUDUR SMITH, C, WILLIAMSON, P. R

“…Several observational studies have claimed high success rates for cerclage in women with cervical insufficiency. A recent Cochrane review found no conclusive…”
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Proteomic and peptidomic study of proteolysis in quarter milk after infusion with lipoteichoic acid from Staphylococcus aureus by Larsen, L B, Hinz, K, Jørgensen, A L W, Møller, H S, Wellnitz, O, Bruckmaier, R M, Kelly, A L

“…Mastitic milk is associated with increased bovine protease activity, such as that from plasmin and somatic cell enzymes, which cause proteolysis of the caseins…”
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NAT2 variants and toxicity related to anti-tuberculosis agents: a systematic review and meta-analysis by Richardson, M., Kirkham, J., Dwan, K., Sloan, D. J., Davies, G., Jorgensen, A. L.

“…BACKGROUND: Tuberculosis (TB) patients receiving anti-tuberculosis treatment may experience serious adverse drug reactions (ADRs) such as hepatotoxicity…”
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The molecular genetics of chemotherapy–induced peripheral neuropathy: A systematic review and meta-analysis by Cliff, J., Jorgensen, A.L., Lord, R., Azam, F., Cossar, L., Carr, D.F., Pirmohamed, M.

“…•Evidence for genetic variants associated with CIPN is currently inconclusive.•Several SNPs are of interest and warrant further study.•Clear and consistent…”
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Clinical predictors of active LN development in children – evidence from the UK JSLE Cohort Study by Smith, E M D, Yin, P, Jorgensen, A L, Beresford, M W

“…Background Juvenile-onset systemic lupus erythematosus (JSLE) patients may develop lupus nephritis (LN) during their initial presentation, or later in their…”
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Growing international evidence for urinary biomarker panels identifying lupus nephritis in children – verification within the South African Paediatric Lupus Cohort by Smith, E M D, Lewandowski, L B, Jorgensen, A L, Phuti, A, Nourse, P, Scott, C, Beresford, M W

“…Background A urinary biomarker panel including alpha-1-acid-glycoprotein (AGP), lipocalin-like-prostaglandin-D-synthase (LPGDS), transferrin and ceruloplasmin…”
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Do classic blood biomarkers of JSLE identify active lupus nephritis? Evidence from the UK JSLE Cohort Study by Smith, E M D, Jorgensen, A L, Beresford, M W

“…Background Lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus (JSLE) patients. The value of commonly available biomarkers,…”
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Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing by Lenzini, P, Wadelius, M, Kimmel, S, Anderson, J L, Jorgensen, A L, Pirmohamed, M, Caldwell, M D, Limdi, N, Burmester, J K, Dowd, M B, Angchaisuksiri, P, Bass, A R, Chen, J, Eriksson, N, Rane, A, Lindh, J D, Carlquist, J F, Horne, B D, Grice, G, Milligan, P E, Eby, C, Shin, J, Kim, H, Kurnik, D, Stein, C M, McMillin, G, Pendleton, R C, Berg, R L, Deloukas, P, Gage, B F

“…Well‐characterized genes that affect warfarin metabolism (cytochrome P450 (CYP) 2C9) and sensitivity (vitamin K epoxide reductase complex 1 (VKORC1)) explain…”
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Piglets born from handmade cloning, an innovative cloning method without micromanipulation by Du, Y., Kragh, P.M., Zhang, Y., Li, J., Schmidt, M., Bøgh, I.B., Zhang, X., Purup, S., Jørgensen, A.L., Pedersen, A.M., Villemoes, K., Yang, H., Bolund, L., Vajta, G.

“…Porcine handmade cloning (HMC), a simplified alternative of micromanipulation based traditional cloning (TC) has been developed in multiple phases during the…”
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Sequence Divergence of the Red and Green Visual Pigments in Great Apes and Humans by Deeb, Samir S., Jorgensen, A. Lund, Battisti, Laurie, Iwasaki, Lori, Motulsky, Arno G.

“…We have determined the coding sequences of red and green visual pigment genes of the chimpanzee, gorilla, and orangutan. The deduced amino acid sequences of…”
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Efficiency of Two Enucleation Methods Connected to Handmade Cloning to Produce Transgenic Porcine Embryos by Li, J, Villemoes, K, Zhang, Y, Du, Y, Kragh, PM, Purup, S, Xue, Q, Pedersen, AM, Jørgensen, AL, Jakobsen, JE, Bolund, L, Yang, H, Vajta, G

“…The purpose of our work was to establish an efficient-oriented enucleation method to produce transgenic embryos with handmade cloning (HMC). After 41-42 h…”
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Budesonide/formoterol adjustable maintenance dosing reduces asthma exacerbations versus fixed dosing by Ställberg, B, Olsson, P, Jörgensen, L A, Lindarck, N, Ekström, T

“…A guided, adjustable-dosing regimen with budesonide/formoterol was investigated in asthma patients. In a randomised, open, multicentre study, 1034 patients…”
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The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific by Lovestone, S, Anderton, B H, Hartley, C, Jensen, T G, Jorgensen, A L

“…The apolipoprotein E (apoE) gene has been identified as a susceptibility gene for Alzheimer's disease, although the mechanism whereby apoE exerts this effect…”
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Cervical Stitch (Cerclage) for Preventing Pregnancy Loss: Individual Patient Data Meta-Analysis by Jorgensen, A L, Alfirevic, Z, Smith, C Tudur, Williamson, P R

“…Numerous observational studies done over the past 5 decades have claimed improved pregnancy outcomes in women with cervical insufficiency following…”
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Breakpoints in Robertsonian translocations are localized to satellite III DNA by fluorescence in situ hybridization by Gravholt, C H, Friedrich, U, Caprani, M, Jørgensen, A L

“…We characterized 21 t(13;14) and 3 t(14;21) Robertsonian translocations for the presence of DNA derived from the short arms of the translocated acrocentric…”
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Grasping the handrails during treadmill walking does not alter sagittal plane kinematics of walking by Siler, W L, Jorgensen, A L, Norris, R A

“…To determine whether grasping the handrails during treadmill walking affects sagittal plane kinematic parameters selected to describe walking style. Crossover…”
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