Hydrophilic surface of Ti6Al4V‐ELI alloy improves the early bone apposition of sheep tibia

Objective The aim of this preclinical study was to compare histologically and histomorphometrically both sandblasted/acid‐etched implant surfaces with or without maintained in an isotonic solution of 0.9% sodium chloride in early stages of osseointegration. Material and methods Both implant surfaces...

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Bibliographic Details
Published in:	Clinical oral implants research Vol. 28; no. 8; pp. 893 - 901
Main Authors:	Sartoretto, Suelen C., Alves, Adriana T. N. N., Zarranz, Laila, Jorge, Mônica Z., Granjeiro, José M., Calasans‐Maia, Mônica D.
Format:	Journal Article
Language:	English
Published:	Denmark Wiley Subscription Services, Inc 01-08-2017
Subjects:	Acids Aluminum Animals Apposition Bone growth Bone implants Bone-Implant Interface - pathology Confocal microscopy Contact angle Dental Implantation, Endosseous - methods Dental Implants Dentistry Electron microscopy Etching Evaluation Healing hydrophilicity Hydrophobic and Hydrophilic Interactions Microscopy, Confocal Microscopy, Electron, Scanning Morphology Osseointegration Osteogenesis Photoelectron spectroscopy Scanning electron microscopy Sheep Sodium chloride Spectroscopic analysis Spectroscopy Surface Properties Surgical implants Ti6Al4V‐ELI alloy Tibia Tibia - pathology Tibia - surgery Titanium Titanium alloys Titanium base alloys Topography Vanadium Wettability X ray photoelectron spectroscopy X-rays osseointegration dental implants sheep Ti6Al4V-ELI alloy hydrophilicity
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Summary:	Objective The aim of this preclinical study was to compare histologically and histomorphometrically both sandblasted/acid‐etched implant surfaces with or without maintained in an isotonic solution of 0.9% sodium chloride in early stages of osseointegration. Material and methods Both implant surfaces were composed of a titanium/aluminum/vanadium alloy (Ti6Al4V‐ELI), but they had different surface chemistries: sandblasted/acid‐etched titanium surface (FN) or sandblasted/acid‐etched surface maintained in an isotonic solution of 0.9% sodium chloride (FA). The surface morphology, topography and chemistry were evaluated by scanning electron microscopy (SEM), confocal microscopy (CM) and X‐ray photoelectron spectroscopy (XPS), respectively. Dynamic contact angle (DCA) was employed for wettability evaluation. One implant from each group was placed in the left tibia of twenty healthy, skeletally mature Santa Ines sheep (n = 5). Bone area (BA) and bone‐to‐implant contact (BIC) were performed on thin sections (30 μm) at 7, 14, 21 and 28 days after implant installation. Results Despite the roughness and morphology similarities between the groups, at the XPS evaluation, the FA group presented 2.3 times less carbon on the surface (FN: 27.3% and FA: 11.6%), sharply enhanced hydrophilicity and significantly enhanced BA and BIC at 14, 21 and 28 days of healing (P < 0.05) compared with the FN. Conclusion The data suggest that the hydrophilic FA accelerates the BA apposition and BIC interface around the implants during early stages of bone formation, providing highest degree of osseointegration.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0905-7161 1600-0501
DOI:	10.1111/clr.12894