Large area high-resolution CCD-based X-ray detector for macromolecular crystallography

An X-ray detector system for macromolecular crystallography based on a large area charge-coupled device (CCD) sensor has been developed as part of a large research and development programme for advanced X-ray sensor technology, funded by industry and the Particle Physics and Astronomy Research Counc...

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Bibliographic Details
Published in:	Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment Vol. 477; no. 1; pp. 166 - 171
Main Authors:	Pokrić, Maja, Allinson, Nigel M, Jorden, A.R, Cox, M.P, Marshall, A, Long, P.G, Moon, K, Jerram, P, Pool, P, Nave, C, Derbyshire, G.E, Helliwell, J.R
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 21-01-2002
Subjects:	Crystallography Data processing Detector optimisation Large area CCD Data processing 07.85.Qe Large area CCD Detector optimisation 07.85.F Crystallography
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Summary:	An X-ray detector system for macromolecular crystallography based on a large area charge-coupled device (CCD) sensor has been developed as part of a large research and development programme for advanced X-ray sensor technology, funded by industry and the Particle Physics and Astronomy Research Council (PPARC) in the UK. The prototype detector consists of two large area three-sides buttable charge-coupled devices (CCD 46-62 EEV), where the single CCD area is 55.3 mm×41.5 mm. Overall detector imaging area is easily extendable to 85 mm×110 mm. The detector consists of an optically coupled X-ray sensitive phosphor, skewed fibre-optic studs and CCDs. The crystallographic measurement requirements at synchrotron sources are met through a high spatial resolution (2048×1536 pixel array), high dynamic range (∼10 5), a fast readout (∼1 s), low noise (<10e −) and much reduced parallax error. Additionally, the prototype detector system has been optimised by increasing its efficiency at low X-ray energies for use at conventional lab sources. The system design of the prototype detector is discussed and the proposed method for crystallographic data processing is briefly outlined.
ISSN:	0168-9002 1872-9576
DOI:	10.1016/S0168-9002(01)01881-2