Search Results - "Jordanova, Ekaterina"

Prognostic Significance of MYC Rearrangement and Translocation Partner in Diffuse Large B-Cell Lymphoma: A Study by the Lunenburg Lymphoma Biomarker Consortium by Rosenwald, Andreas, Bens, Susanne, Advani, Ranjana, Barrans, Sharon, Copie-Bergman, Christiane, Elsensohn, Mad-Helenie, Natkunam, Yaso, Calaminici, Maria, Sander, Birgitta, Baia, Maryse, Smith, Alexandra, Painter, Daniel, Pham, Luu, Zhao, Shuchun, Ziepert, Marita, Jordanova, Ekaterina S, Molina, Thierry J, Kersten, Marie José, Kimby, Eva, Klapper, Wolfram, Raemaekers, John, Schmitz, Norbert, Jardin, Fabrice, Stevens, Wendy B C, Hoster, Eva, Hagenbeek, Anton, Gribben, John G, Siebert, Reiner, Gascoyne, Randy D, Scott, David W, Gaulard, Philippe, Salles, Gilles, Burton, Catherine, de Jong, Daphne, Sehn, Laurie H, Maucort-Boulch, Delphine

“…rearrangement ( -R) occurs in approximately 10% of diffuse large B-cell lymphomas (DLBCLs) and has been associated with poor prognosis in many studies. The…”
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Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix by Heeren, A Marijne, Punt, Simone, Bleeker, Maaike CG, Gaarenstroom, Katja N, van der Velden, Jacobus, Kenter, Gemma G, de Gruijl, Tanja D, Jordanova, Ekaterina S

“…Programmed death-ligand 1 (PD-L1) is expressed in various immune cells and tumor cells, and is able to bind to PD-1 on T lymphocytes, thereby inhibiting their…”
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Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer by Punt, Simone, Thijssen, Victor L, Vrolijk, Johannes, de Kroon, Cornelis D, Gorter, Arko, Jordanova, Ekaterina S

“…Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9…”
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Targetable genetic features of primary testicular and primary central nervous system lymphomas by Chapuy, Bjoern, Roemer, Margaretha G.M., Stewart, Chip, Tan, Yuxiang, Abo, Ryan P., Zhang, Liye, Dunford, Andrew J., Meredith, David M., Thorner, Aaron R., Jordanova, Ekaterina S., Liu, Gang, Feuerhake, Friedrich, Ducar, Matthew D., Illerhaus, Gerald, Gusenleitner, Daniel, Linden, Erica A., Sun, Heather H., Homer, Heather, Aono, Miyuki, Pinkus, Geraldine S., Ligon, Azra H., Ligon, Keith L., Ferry, Judith A., Freeman, Gordon J., van Hummelen, Paul, Golub, Todd R., Getz, Gad, Rodig, Scott J., de Jong, Daphne, Monti, Stefano, Shipp, Margaret A.

“…Primary central nervous system lymphomas (PCNSLs) and primary testicular lymphomas (PTLs) are extranodal large B-cell lymphomas (LBCLs) with inferior responses…”
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Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site by Kamal, Maud, Lameiras, Sonia, Deloger, Marc, Morel, Adeline, Vacher, Sophie, Lecerf, Charlotte, Dupain, Célia, Jeannot, Emmanuelle, Girard, Elodie, Baulande, Sylvain, Dubot, Coraline, Kenter, Gemma, Jordanova, Ekaterina S., Berns, Els M. J. J., Bataillon, Guillaume, Popovic, Marina, Rouzier, Roman, Cacheux, Wulfran, Le Tourneau, Christophe, Nicolas, Alain, Servant, Nicolas, Scholl, Suzy M., Bièche, Ivan

“…Background Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most…”
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Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression by Baglio, S Rubina, Lagerweij, Tonny, Pérez-Lanzón, Maria, Ho, Xuan Dung, Léveillé, Nicolas, Melo, Sonia A, Cleton-Jansen, Anne-Marie, Jordanova, Ekaterina S, Roncuzzi, Laura, Greco, Michelina, van Eijndhoven, Monique A J, Grisendi, Giulia, Dominici, Massimo, Bonafede, Roberta, Lougheed, Sinead M, de Gruijl, Tanja D, Zini, Nicoletta, Cervo, Silvia, Steffan, Agostino, Canzonieri, Vincenzo, Martson, Aare, Maasalu, Katre, Köks, Sulev, Wurdinger, Tom, Baldini, Nicola, Pegtel, D Michiel

“…Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because…”
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Unlocking the therapeutic potential of primary tumor-draining lymph nodes by Rotman, Jossie, Koster, Bas D., Jordanova, Ekaterina S., Heeren, A. Marijne, de Gruijl, Tanja D.

“…Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune…”
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Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition by Eggink, Florine A., Van Gool, Inge C., Leary, Alexandra, Pollock, Pamela M., Crosbie, Emma J., Mileshkin, Linda, Jordanova, Ekaterina S., Adam, Julien, Freeman-Mills, Luke, Church, David N., Creutzberg, Carien L., De Bruyn, Marco, Nijman, Hans W., Bosse, Tjalling

“…High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced…”
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Penile intraepithelial neoplasia incidence, clinical classification, microenvironment and implications for imiquimod treatment by Avitan, Ofir, Rafael, Tynisha, Vreeburg, Manon, Elst, Laura, Bekers, Elise M., Albersen, Maarten, Jordanova, Ekaterina S., Brouwer, Oscar

“…Objectives To provide an outline of the existing data on penile intraepithelial neoplasia (PeIN), as well as a narrative review on imiquimod (IQ; a toll‐like…”
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Expression of Programmed Death Ligand 1 in Penile Cancer is of Prognostic Value and Associated with HPV Status by Ottenhof, Sarah R, Djajadiningrat, Rosa S, de Jong, Jeroen, Thygesen, Helene H, Horenblas, Simon, Jordanova, Ekaterina S

“…Purpose PD-L1 (programmed death ligand 1) inhibits T-cell function and prevents tumor eradication. This is facilitated by PD-L1 positive tumor cells and PD-L1…”
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Precise Classification of Cervical Carcinomas Combined with Somatic Mutation Profiling Contributes to Predicting Disease Outcome by Spaans, Vivian M, Trietsch, Marjolijn D, Peters, Alexander A W, Osse, Michelle, Ter Haar, Natalja, Fleuren, Gert J, Jordanova, Ekaterina S

“…Squamous cell carcinoma (SCC), adenocarcinoma (AC), and adenosquamous carcinoma (ASC) are the most common histological subtypes of cervical cancer. Differences…”
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HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8+T lymphocytes by Gooden, Marloes, Lampen, Margit, Jordanova, Ekaterina S., Leffers, Ninke, Trimbos, J. Baptist, van der Burg, Sjoerd H., Nijman, Hans, van Hall, Thorbald

“…HLA-E is a nonclassical HLA class I molecule, which differs from classical HLA molecules by its nonpolymorphic, conserved nature. Expression and function of…”
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Circulating HPV DNA as a Marker for Early Detection of Relapse in Patients with Cervical Cancer by Jeannot, Emmanuelle, Latouche, Aurélien, Bonneau, Claire, Calméjane, Marie-Ange, Beaufort, Corine, Ruigrok-Ritstier, Kirsten, Bataillon, Guillaume, Larbi Chérif, Linda, Dupain, Célia, Lecerf, Charlotte, Popovic, Marina, de la Rochefordière, Anne, Lecuru, Fabrice, Fourchotte, Virginie, Jordanova, Ekaterina S, von der Leyen, Heiko, Tran-Perennou, Carine, Legrier, Marie-Emmanuelle, Dureau, Sylvain, Raizonville, Laurence, Bello Roufai, Diana, Le Tourneau, Christophe, Bièche, Ivan, Rouzier, Roman, Berns, Els M J J, Kamal, Maud, Scholl, Suzy

“…Almost all cervical cancers are caused by human papillomavirus (HPV) and patients with advanced stage are at high risk for relapse. Circulating HPV DNA (HPV…”
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Intratumoral HPV16-Specific T Cells Constitute a Type I-Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer by Welters, Marij J P, Ma, Wenbo, Santegoets, Saskia J A M, Goedemans, Renske, Ehsan, Ilina, Jordanova, Ekaterina S, van Ham, Vanessa J, van Unen, Vincent, Koning, Frits, van Egmond, Sylvia I, Charoentong, Pornpimol, Trajanoski, Zlatko, van der Velden, Lilly-Ann, van der Burg, Sjoerd H

“…Human papillomavirus (HPV)-associated oropharyngeal squamous cell cancer (OPSCC) has a much better prognosis than HPV-negative OPSCC, and this is linked to…”
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PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential by Rotman, Jossie, den Otter, Leontine A S, Bleeker, Maaike C G, Samuels, Sanne S, Heeren, A Marijne, Roemer, Margaretha G M, Kenter, Gemma G, Zijlmans, Henry J M A A, van Trommel, Nienke E, de Gruijl, Tanja D, Jordanova, Ekaterina S

“…PD-1/PD-L1 immune checkpoint inhibitors show potential for cervical cancer treatment. However, low response rates suggest that patient selection based on PD-L1…”
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Tumor-Expressed B7-H1 and B7-DC in Relation to PD-1+ T-Cell Infiltration and Survival of Patients with Cervical Carcinoma by Karim, Rezaul, Jordanova, Ekaterina S, Piersma, Sytse J, Kenter, Gemma G, Chen, Lieping, Boer, Judith M, Melief, Cornelis J M, van der Burg, Sjoerd H

“…Purpose: The interaction between programmed cell death 1 (PD-1), expressed by activated effector or regulatory T cells, and B7-H1 (PD-L1) and B7-DC (PD-L2)…”
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Atezolizumab With or Without Radiotherapy for Advanced Squamous Cell Carcinoma of the Penis (The PERICLES Study): A Phase II Trial by de Vries, Hielke M, Rafael, Tynisha S, Gil-Jimenez, Alberto, de Feijter, Jeantine M, Bekers, Elise, van der Laan, Elsbeth, Lopez-Yurda, Marta, Hooijberg, Erik, Broeks, Annegien, Peters, Dennis, Seignette, Iris M, Pos, Floris J, Horenblas, Simon, van Rhijn, Bas W G, Jordanova, Ekaterina S, Brouwer, Oscar R, Schaake, Eva, van der Heijden, Michiel S

“…Patients with advanced penile squamous cell carcinoma have a poor prognosis (21% 2-year overall survival [OS] from diagnosis). We assessed the activity of…”
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Immune Cell Infiltrate in Chronic-Active Antibody-Mediated Rejection by Sablik, Kasia A, Jordanova, Ekaterina S, Pocorni, Noelle, Clahsen-van Groningen, Marian C, Betjes, Michiel G H

“…Little is known about immune cell infiltrate type in the kidney allograft of patients with chronic-active antibody-mediated rejection (c-aABMR). In this study,…”
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PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma by Gezgin, Gülçin, Luk, Sietse J, Cao, Jinfeng, Dogrusöz, Mehmet, van der Steen, Dirk M, Hagedoorn, Renate S, Krijgsman, Daniëlle, van der Velden, Pieter A, Field, Matthew G, Luyten, Gregorius P M, Szuhai, Karoly, Harbour, J William, Jordanova, Ekaterina S, Heemskerk, Mirjam H M, Jager, Martine J

“…Uveal melanoma (UM) is an intraocular primary malignant neoplasm that often gives rise to metastatic disease for which there are no effective therapies. A…”
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Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension by Manz, Xue D, Szulcek, Robert, Pan, Xiaoke, Symersky, Petr, Dickhoff, Chris, Majolée, Jisca, Kremer, Veerle, Michielon, Elisabetta, Jordanova, Ekaterina S, Radonic, Teodora, Bijnsdorp, Irene V, Piersma, Sander R, Pham, Thang V, Jimenez, Connie R, Vonk Noordegraaf, Anton, de Man, Frances S, Boon, Reinier A, Voorberg, Jan, Hordijk, Peter L, Aman, Jurjan, Bogaard, Harm Jan

“…von Willebrand factor (vWF) mediates platelet adhesion during thrombosis. While chronic thromboembolic pulmonary hypertension (CTEPH) is associated with…”
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