Search Results - "Jordan, Shaun"

The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor by JORDAN, Shaun, KOPRIVICA, Vuk, RUOYAN CHEN, TOTTORI, Katsura, KIKUCHI, Tetsuro, ALTAR, C. Anthony

“…Aripiprazole, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy]-3,4-dihydro-2(1H)-quinolinone, a novel antipsychotic with partial agonist activity at…”
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Aripiprazole protects cortical neurons from glutamate toxicity by Koprivica, Vuk, Regardie, Karen, Wolff, Christina, Fernalld, Raymond, Murphy, Janelle Johnson, Kambayashi, Junichi, Kikuchi, Tetsuro, Jordan, Shaun

“…Neurodegeneration is thought to be a component of schizophrenia pathology, and some antipsychotics appear to slow degenerative changes in patients…”
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In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function by Jordan, Shaun, Koprivica, Vuk, Dunn, Robert, Tottori, Katsura, Kikuchi, Tetsuro, Altar, C.Anthony

“…In vivo microdialysis was used to monitor the effects of oral aripiprazole and olanzapine on basal extracellular concentrations of dopamine,…”
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Dopamine D2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D2 receptor signaling by JORDAN, Shaun, JOHNSON, Janelle L, REGARDIE, Karen, RUOYAN CHEN, KOPRIVICA, Vuk, TADORI, Yoshihiro, KAMBAYASHI, Junichi, KITAGAWA, Hisashi, KIKUCHI, Tetsuro

“…Clinical evidence suggests that dopamine D(2) receptor partial agonists must have a sufficiently low intrinsic activity to be effective as antipsychotics…”
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6-[ 18F]Fluoro- l- m-tyrosine: metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates by Jordan, Shaun, Eberling, Jamie L, Bankiewicz, Krzysztof S, Rosenberg, Daniel, Coxson, Pamela G, VanBrocklin, Henry F, O'Neil, James P, Emborg, Marina E, Jagust, William J

“…The tracer 6-[ 18F]fluoro- l- m-tyrosine (FMT) was studied with regard to its biochemistry and kinetics, as well as its utility in evaluating brain…”
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Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT2A receptors : functional receptor-binding and in vivo electrophysiological studies by STARK, Arlene D, JORDAN, Shaun, BURRIS, Kevin D, ALLERS, Kelly A, BERTEKAP, Robert L, CHEN, Ruoyan, MISTRY KANNAN, Tanaz, MOLSKI, Thaddeus F, YOCCA, Frank D, SHARP, Trevor, KIKUCHI, Tetsuro

“…Background Aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone) is a novel antipsychotic with a mechanism of action…”
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Acthar gel treatment suppresses acute exacerbations in a murine model of relapsing-remitting multiple sclerosis by Cusick, Matthew F., Libbey, Jane E., Oh, Luke, Jordan, Shaun, Fujinami, Robert S.

“…Abstract Acthar gel is indicated for the treatment of acute exacerbations of multiple sclerosis (MS) in adults. Its effects on immune cells during a relapse…”
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In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D2 receptors by JORDAN, Shaun, RUOYAN CHEN, FERNALLD, Raymond, JOHNSON, Janelle, REGARDIE, Karen, KAMBAYASHI, Junichi, TADORI, Yoshihiro, KITAGAWA, Hisashi, KIKUCHI, Tetsuro

“…Dopamine potently increased calcium mobilization in Chinese hamster ovary cells expressing human dopamine D2Long receptors (CHO-D2L cells), and increased…”
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Dopamine D 2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D 2 receptor signaling by Jordan, Shaun, Johnson, Janelle L., Regardie, Karen, Chen, Ruoyan, Koprivica, Vuk, Tadori, Yoshihiro, Kambayashi, Junichi, Kitagawa, Hisashi, Kikuchi, Tetsuro

“…Clinical evidence suggests that dopamine D 2 receptor partial agonists must have a sufficiently low intrinsic activity to be effective as antipsychotics. Here,…”
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In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D 2 receptors by Jordan, Shaun, Chen, Ruoyan, Fernalld, Raymond, Johnson, Janelle, Regardie, Karen, Kambayashi, Junichi, Tadori, Yoshihiro, Kitagawa, Hisashi, Kikuchi, Tetsuro

“…Dopamine potently increased calcium mobilization in Chinese hamster ovary cells expressing human dopamine D 2Long receptors (CHO-D 2L cells), and increased…”
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In vitro functional characteristics of dopamine D2 receptor partial agonists in second and third messenger-based assays of cloned human dopamine D2Long receptor signalling by Jordan, Shaun, Regardie, Karen, Johnson, Janelle L., Ruoyan Chen, Kambayashi, Junichi, McQuade, Robert, Kitagawa, Hisashi, Tadori, Yoshihiro, Kikuchi, Tetsuro

“…Aripiprazole, (+)terguride, OPC-4392 and (—)3-PPP have been classified as dopamine D2 receptor partial agonists based largely on their activity in second…”
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In vitro functional characteristics of dopamine [D.sub.2] receptor partial agonists in second and third messenger-based assays of cloned human dopamine [D.sub.2Long] receptor signaling by Jordan, Shaun, Regardie, Karen, Johnson, Janelle L, Chen, Ruoyan, Kambayashi, Junichi, McQuade, Robert, Kitagawa, Hisashi, Tadori, Yoshihiro, Kikuchi, Tetsuro

“…Aripiprazole, (+)terguride, OPC-4392 and (-)3-PPP have been classified as dopamine [D.sub.2] receptor partial agonists based largely on their activity in…”
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In vitro functional characteristics of dopamine D^sub 2^ receptor partial agonists in second and third messenger-based assays of cloned human dopamine D^sub 2Long^ receptor signalling by Jordan, Shaun, Regardie, Karen, Johnson, Janelle L, Chen, Ruoyan, Kambayashi, Junichi, McQuade, Robert, Kitagawa, Hisashi, Tadori, Yoshihiro, Kikuchi, Tetsuro

“…Aripiprazole, (+)terguride, OPC-4392 and (-)3-PPP have been classified as dopamine Dsub2 receptor partial agonists based largely on their activity in second…”
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In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D sub(2) receptors by Jordan, Shaun, Chen, Ruoyan, Fernalld, Raymond, Johnson, Janelle, Regardie, Karen, Kambayashi, Junichi, Tadori, Yoshihiro, Kitagawa, Hisashi, Kikuchi, Tetsuro

“…Dopamine potently increased calcium mobilization in Chinese hamster ovary cells expressing human dopamine D sub(2Long) receptors (CHO-D sub(2L) cells), and…”
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Dopamine D sub(2) receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D sub(2) receptor signaling by Jordan, Shaun, Johnson, Janelle L, Regardie, Karen, Chen, Ruoyan, Koprivica, Vuk, Tadori, Yoshihiro, Kambayashi, Junichi, Kitagawa, Hisashi, Kikuchi, Tetsuro

“…Clinical evidence suggests that dopamine D sub(2) receptor partial agonists must have a sufficiently low intrinsic activity to be effective as antipsychotics…”
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In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT sub(1A) receptors by Jordan, Shaun, Chen, Ruoyan, Koprivica, Vuk, Hamilton, Ronald, Whitehead, Richard E, Tottori, Katsura, Kikuchi, Tetsuro

“…This study determined the in vitro functional profile of 1-[3-[4-(3- chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinol inone…”
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Altered emotional behaviors in the diabetes mellitus OLETF type 1 congenic rat by Watanabe, Akihito, Okuno, Shiro, Okano, Mai, Jordan, Shaun, Aihara, Koutoku, Watanabe, Takeshi K, Yamasaki, Yuki, Kitagawa, Hisashi, Sugawara, Kiyoshi, Kato, Satoru

“…Abstract GPR10 is a G-protein-coupled receptor expressed in thalamic and hypothalamic brain regions, including the reticular thalamic nucleus (RTN) and…”
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In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT 1A receptors by Jordan, Shaun, Chen, Ruoyan, Koprivica, Vuk, Hamilton, Ronald, Whitehead, Richard E., Tottori, Katsura, Kikuchi, Tetsuro

“…This study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone…”
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In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors by JORDAN, Shaun, RUOYAN CHEN, KOPRIVICA, Vuk, HAMILTON, Ronald, WHITEHEAD, Richard E, TOTTORI, Katsura, KIKUCHI, Tetsuro

“…This study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone…”
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Interaction of the novel antipsychotic aripiprazole with 5-HT sub(1A) and 5-HT sub(2A) receptors: functional receptor-binding and in vivo electrophysiological studies by Stark, Arlene D, Jordan, Shaun, Allers, Kelly A, Bertekap, Robert L, Chen, Ruoyan, Mistry Kannan, Tanaz, Molski, Thaddeus F, Yocca, Frank D, Sharp, Trevor, Kikuchi, Tetsuro, Burris, Kevin D

“…Background: Aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2( 1 H)-quinolinone) is a novel antipsychotic with a mechanism of…”
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