Levels of Expression of P-Selectin, E-Selectin, and Intercellular Adhesion Molecule-1 in Coronary Atherectomy Specimens from Patients With Stable and Unstable Angina Pectoris

Unstable angina occurs when atherosclerotic plaque ruptures. Recent evidence suggests a role for inflammation in this process. Leukocyte-endothelial cell interactions are important in inflammation and are regulated by cell adhesion molecules. This study was designed to examine the vascular expressio...

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Bibliographic Details
Published in:	The American journal of cardiology Vol. 79; no. 6; pp. 742 - 747
Main Authors:	Tenaglia, Alan N, Buda, Andrew J, Wilkins, Robert G, Barron, Michael K, Jeffords, Paul R, Vo, Khoa, Jordan, Maureen O, Kusnick, Barry A, Lefer, David J
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 15-03-1997 Elsevier Elsevier Limited
Subjects:	Adhesion Adult Aged Aged, 80 and over Angina Angina pectoris Angina Pectoris - metabolism Angina Pectoris - surgery Angina, Unstable - metabolism Angina, Unstable - surgery Angioplasty Arteriosclerosis Arteriosclerosis - metabolism Arteriosclerosis - surgery Atherectomy, Coronary Atherosclerosis Biological and medical sciences Blood clots Cardiology. Vascular system Cardiovascular disease Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell interactions Cellular biology Coronary heart disease Coronary vessels Coronary Vessels - metabolism Coronary Vessels - surgery Cytokines Dissection E-selectin E-Selectin - metabolism Endothelial cells Endothelium Female Heart Heart attacks Humans Immunoglobulins Immunohistochemistry Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - metabolism Interleukin-1 - metabolism Interleukins Ischemia Leukocytes Male Medical procedures Medical sciences Middle Aged Molecular chains P-selectin P-Selectin - metabolism Patients Smooth muscle Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α United States > US Connecticut California Human Immunohistochemistry Atherectomy E Selectin Coronary artery Cell adhesion molecule Cardiovascular disease Exploration Angina pectoris Coronary heart disease Adhesion P Selectin Pathology Variant angina
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Summary:	Unstable angina occurs when atherosclerotic plaque ruptures. Recent evidence suggests a role for inflammation in this process. Leukocyte-endothelial cell interactions are important in inflammation and are regulated by cell adhesion molecules. This study was designed to examine the vascular expression of cell adhesion molecules and cytokines in patients with unstable angina. Directional coronary atherectomy was performed in patients with unstable and stable angina. Expression of the cell adhesion molecules P-selectin, E-selectin, and intercellular adhesion molecule-1 in the tissue obtained was examined using immunohistochemistry. In addition, expression of the cytokines tumor necrosis factor-α and interleukin-1β, which participate in the regulation of cell adhesion molecule expression, was also examined. Atherectomy specimens had significantly greater P-selectin expression from patients with unstable angina than from patients with stable angina. P-selectin expression was observed primarily on endothelial cells. There were no differences in any of the other factors between patients with unstable and stable angina. In addition, other clinical and angiographic variables were not associated with differential expression of any of the cell adhesion molecules or cytokines. These results indicate a possible role for P-selectin in the process of unstable angina. Expression of the cell adhesion molecules P-selectin, E-selectin, and intercellular adhesion molecule-1 in specimens obtained by directional coronary atherectomy was examined using immunohistochemistry. Atherectomy specimens revealed significantly greater P-selectin expression from patients with unstable angina than from patients with stable angina. P-selectin expression was observed primarily on endothelial cells, and there were no differences in expression of the other factors between patients with unstable angina and stable angina; results indicate a possible role for P-selectin in the process of unstable angina.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(96)00861-2