Search Results - "Jorcano, Jose L."

In vitro and In vivo Wound Healing-Promoting Activities of Human Cathelicidin LL-37 by Carretero, Marta, Escámez, María J., García, Marta, Duarte, Blanca, Holguín, Almudena, Retamosa, Luisa, Jorcano, Jose L., Río, Marcela del, Larcher, Fernando

“…The human antimicrobial peptide LL-37 plays an important role in host defense against infection. In addition to its antimicrobial action, other activities have…”
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Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications by López-Iglesias, Clara, Quílez, Cristina, Barros, Joana, Velasco, Diego, Alvarez-Lorenzo, Carmen, Jorcano, José L., Monteiro, Fernando J., García-González, Carlos A.

“…The delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound…”
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Long-term Engraftment of Single Genetically Modified Human Epidermal Holoclones Enables Safety Pre-assessment of Cutaneous Gene Therapy by Larcher, Fernando, Dellambra, Elena, Rico, Laura, Bondanza, Sergio, Murillas, Rodolfo, Cattoglio, Claudia, Mavilio, Fulvio, Jorcano, José L, Zambruno, Giovanna, Del Rio, Marcela

“…Predicting the risks of permanent gene therapy approaches involving the use of integrative gene-targeting vectors has become a critical issue after the…”
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Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes by Brakebusch, Cord, Grose, Richard, Quondamatteo, Fabio, Ramirez, Angel, Jorcano, Jose L., Pirro, Alison, Svensson, Marcus, Herken, Rainer, Sasaki, Takako, Timpl, Rupert, Werner, Sabine, Fässler, Reinhard

“…β1 integrins are ubiquitously expressed receptors that mediate cell–cell and cell–extracellular matrix interactions. To analyze the function of β1 integrin in…”
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3D bioprinting of functional human skin: production and in vivo analysis by Cubo, Nieves, Garcia, Marta, Del Cañizo, Juan F, Velasco, Diego, Jorcano, Jose L

“…Significant progress has been made over the past 25 years in the development of in vitro-engineered substitutes that mimic human skin, either to be used as…”
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Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors by Alameda, Josefa P, Moreno-Maldonado, Rodolfo, Fernández-Aceñero, M Jesús, Navarro, Manuel, Page, Angustias, Jorcano, José L, Bravo, Ana, Ramírez, Ángel, Casanova, M Llanos

“…Non-melanoma skin cancer is the most frequent type of cancer in humans. In this study we demonstrate that elevated IKKα expression in murine epidermis…”
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A keratin K5Cre transgenic line appropriate for tissue-specific or generalized cre-mediated recombination by Ramirez, Angel, Page, Angustias, Gandarillas, Alberto, Zanet, Jennifer, Pibre, Sophie, Vidal, Miguel, Tusell, Laura, Genesca, Anna, Whitaker, Duncan A., Melton, David W., Jorcano, Jose L.

“…We describe here a mouse line bearing a bovine keratin K5Cre recombinase transgene. These mice showed a dual pattern of Cre‐mediated recombination, depending…”
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Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic/antitumor activities of pigment epithelium-derived factor by GARCIA, Marta, FERNANDEZ-GARCIA, Nuria Isabel, LARCHER, Fernando, DEL RIO, Marcela, RIVAS, Veronica, CARRETERO, Marta, ESCAMEZ, Maria J, GONZALEZ-MARTIN, Alicia, MEDRANO, Estela E, VOLPERT, Olga, JORCANO, Jose L, JIMENEZ, Benilde

“…Human melanoma mortality is associated with the growth of metastasis in selected organs including the lungs, liver, and brain. In this study, we examined the…”
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Functional roles of Akt signaling in mouse skin tumorigenesis by SEGRELLES, Carmen, RUIZ, Sergio, JORCANO, Jose L, PARAMIO, Jesus M, PEREZ, Paloma, MURGA, Cristina, SANTOS, Mirentxu, BUDUNOVA, Irina V, MARTINEZ, Jesus, LARCHER, Fernando, SLAGA, Thomas J, GUTKIND, J. Silvio

“…The mouse skin carcinogenesis protocol is a unique model for understanding the molecular events leading to oncogenic transformation. Mutations in the Ha-ras…”
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ends of a conundrum by Paramio, Jesús M, Santos, Mirentxu, Jorcano, José L

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Interaction of a Migrating Cell Monolayer with a Flexible Fiber by Valencia, Leticia, López-Llorente, Verónica, Lasheras, Juan C., Jorcano, José L., Rodríguez-Rodríguez, Javier

“…Mechanical forces influence the development and behavior of biological tissues. In many situations, these forces are exerted or resisted by elastic compliant…”
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Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130 by Ruiz, Sergio, Segrelles, Carmen, Bravo, Ana, Santos, Mirentxu, Perez, Paloma, Leis, Hugo, Jorcano, Jose L, Paramio, Jesús M

“…The functions of p107 and p130, members of the retinoblastoma family, include the control of cell cycle progression and differentiation in several tissues. Our…”
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Light-Responsive and Antibacterial Graphenic Materials as a Holistic Approach to Tissue Engineering by Ferreras, Andrea, Matesanz, Ana, Mendizabal, Jabier, Artola, Koldo, Nishina, Yuta, Acedo, Pablo, Jorcano, José L., Ruiz, Amalia, Reina, Giacomo, Martín, Cristina

“…While the continuous development of advanced bioprinting technologies is under fervent study, enhancing the regenerative potential of hydrogel-based constructs…”
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Electrospun Polyvinylpyrrolidone-Based Dressings Containing GO/ZnO Nanocomposites: A Novel Frontier in Antibacterial Wound Care by Martín, Cristina, Ferreiro Fernández, Adalyz, Salazar Romero, Julia C, Fernández-Blázquez, Juan P, Mendizabal, Jabier, Artola, Koldo, Jorcano, José L, Rabanal, M Eugenia

“…In recent years, the rapid emergence of antibiotic-resistant bacteria has become a significant concern in the healthcare field, and although bactericidal…”
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Analysis of the Ultraviolet B Response in Primary Human Keratinocytes Using Oligonucleotide Microarrays by Sesto, Angela, Navarro, Manuel, Burslem, Frank, Jorcano, José L.

“…UV radiation is the most important environmental skin aggressor, causing cancer and other problems. This paper reports the use of oligonucleotide microarray…”
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Human plasma as a dermal scaffold for the generation of a completely autologous bioengineered skin by LLAMES, Sara G, DEL RIO, Marcela, LARCHER, Fernando, GARCIA, Eva, GARCIA, Marta, ESCAMEZ, Maria José, JORCANO, Jose L, HOLGUIN, Purificacion, MEANA, Alvaro

“…Keratinocyte cultures have been used for the treatment of severe burn patients. Here, we describe a new cultured bioengineered skin based on (1) keratinocytes…”
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Assessment of Optimal Virus-Mediated Growth Factor Gene Delivery for Human Cutaneous Wound Healing Enhancement by Escámez, María J., Carretero, Marta, García, Marta, Martínez-Santamaría, Lucía, Mirones, Isabel, Duarte, Blanca, Holguín, Almudena, García, Eva, García, Verónica, Meana, Alvaro, Jorcano, José L., Larcher, Fernando, Del Río, Marcela

“…Using a recently described skin-humanized model based on the engraftment of human bioengineered skin equivalents onto immunodeficient mice, we compared the…”
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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes by González-Suárez, Eva, Samper, Enrique, Ramírez, Angel, Flores, Juana M., Martín-Caballero, Juan, Jorcano, José L., Blasco, María A.

“…Telomerase transgenics are an important tool to assess the role of telomerase in cancer, as well as to evaluate the potential use of telomerase for gene…”
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The regenerative potential of fibroblasts in a new diabetes-induced delayed humanised wound healing model by Martínez-Santamaría, Lucía, Conti, Claudio J., Llames, Sara, García, Eva, Retamosa, Luisa, Holguín, Almudena, Illera, Nuria, Duarte, Blanca, Camblor, Lino, Llaneza, José M., Jorcano, José L., Larcher, Fernando, Meana, Álvaro, Escámez, María J., Del Río, Marcela

“…Cutaneous diabetic wounds greatly affect the quality of life of patients, causing a substantial economic impact on the healthcare system. The limited clinical…”
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IKKβ Leads to an Inflammatory Skin Disease Resembling Interface Dermatitis by Page, Angustias, Navarro, Manuel, Garín, Marina, Pérez, Paloma, Llanos Casanova, M., Moreno, Rodolfo, Jorcano, José L., Cascallana, José L., Bravo, Ana, Ramírez, Angel

“…IKKβ is a subunit of the IκB kinase (IKK) complex required for NF-κB activation in response to pro-inflammatory signals. NF-κB regulates the expression of many…”
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