Search Results - "Joppe, Sandra E"
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Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here
Published in The European journal of neuroscience (01-06-2013)“…In the brains of adult vertebrates, including humans, neurogenesis occurs in restricted niches where it maintains cellular turnover and cognitive plasticity…”
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Manipulation of EGFR-Induced Signaling for the Recruitment of Quiescent Neural Stem Cells in the Adult Mouse Forebrain
Published in Frontiers in neuroscience (26-03-2021)“…The ventricular-subventricular zone (V-SVZ) is the principal neurogenic niche in the adult mammalian forebrain. Neural stem/progenitor cell (NSPC) activity…”
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Genetic targeting of neurogenic precursors in the adult forebrain ventricular epithelium
Published in Life science alliance (01-07-2020)“…The ventricular epithelium of the adult forebrain is a heterogeneous cell population that is a source of both quiescent and activated neural stem cells (qNSCs…”
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Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease
Published in Cell stem cell (01-10-2015)“…Lipid metabolism is fundamental for brain development and function, but its roles in normal and pathological neural stem cell (NSC) regulation remain largely…”
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Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model
Published in Nature communications (20-04-2022)“…The defining features of Alzheimer’s disease (AD) include alterations in protein aggregation, immunity, lipid metabolism, synapses, and learning and memory. Of…”
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Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain
Published in The Journal of neuroscience (24-10-2012)“…Adult forebrain neurogenesis is dynamically regulated. Multiple families of niche-derived cues have been implicated in this regulation, but the precise roles…”
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IDENTIFICATION OF A NOVEL LIPID-RELATED DRUG TARGET TO REACTIVATE ADULT NEURAL STEM CELLS IN ALZHEIMER'S DISEASE
Published in Alzheimer's & dementia (01-07-2016)Get full text
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Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here
Published in The European journal of neuroscience (01-07-2013)Get full text
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Bone morphogenetic protein dominantly suppresses epidermal growth factor-induced proliferative expansion of adult forebrain neural precursors
Published in Frontiers in neuroscience (29-10-2015)“…A single asymmetric division by an adult neural stem cell (NSC) ultimately generates dozens of differentiated progeny, a feat made possible by the…”
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O1‐04‐03: Identification of a Novel Lipid‐Related Drug Target to Reactivate Adult Neural Stem Cells in Alzheimer's Disease
Published in Alzheimer's & dementia (01-07-2016)Get full text
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