Search Results - "Jooss, karin"

Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection by Rappaport, Amy R., Hong, Sue-Jean, Scallan, Ciaran D., Gitlin, Leonid, Akoopie, Arvin, Boucher, Gregory R., Egorova, Milana, Espinosa, J. Aaron, Fidanza, Mario, Kachura, Melissa A., Shen, Annie, Sivko, Gloria, Van Abbema, Anne, Veres, Robert L., Jooss, Karin

“…The coronavirus disease 2019 (COVID-19) pandemic continues to spread globally, highlighting the urgent need for safe and effective vaccines that could be…”
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Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial by van den Eertwegh, Alfons JM, MD, Versluis, Jurjen, MD, van den Berg, H Pieter, MD, Santegoets, Saskia JAM, PhD, van Moorselaar, R Jeroen A, Prof, van der Sluis, Tim M, MD, Gall, Helen E, MNAP, Harding, Thomas C, MD, Jooss, Karin, PhD, Lowy, Israel, MD, Pinedo, Herbert M, Prof, Scheper, Rik J, Prof, Stam, Anita GM, BSc, von Blomberg, B Mary E, PhD, de Gruijl, Tanja D, PhD, Hege, Kristen, MD, Sacks, Natalie, MD, Gerritsen, Winald R, Prof

“…Summary Background The granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells vaccine (GVAX) has antitumour activity…”
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GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults by Palmer, Christine D., Scallan, Ciaran D., Kraemer Tardif, Lauren D., Kachura, Melissa A., Rappaport, Amy R., Koralek, Daniel O., Uriel, Alison, Gitlin, Leonid, Klein, Joshua, Davis, Matthew J., Venkatraman, Harshni, Hart, Meghan G., Jaroslavsky, Jason R., Kounlavouth, Sonia, Marrali, Martina, Nganje, Charmaine N., Bae, Kyounghwa, Yan, Tiffany, Leodones, Katharyn, Egorova, Milana, Hong, Sue-Jean, Kuan, Jenchun, Grappi, Silvia, Garbes, Pedro, Jooss, Karin, Ustianowski, Andrew

“…SARS-CoV-2 has resulted in high levels of morbidity and mortality world-wide, and severe complications can occur in older populations. Humoral immunity induced…”
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Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels by YULONG HE, RAJANTIE, Iiro, PAJUSOLA, Katri, JELTSCH, Michael, HOLOPAINEN, Tanja, YLA-HERTTUALA, Seppo, HARDING, Thomas, JOOSS, Karin, TAKAHASHI, Takashi, ALITALO, Kari

“…Lymphangiogenic growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to promote lymphatic metastasis by inducing…”
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Stable antibody expression at therapeutic levels using the 2A peptide by Fang, Jianmin, Qian, Jing-Jing, Yi, Saili, Harding, Thomas C, Tu, Guang Huan, VanRoey, Melinda, Jooss, Karin

“…Therapeutic monoclonal antibodies (mAbs) are currently being developed for the treatment of cancer and other diseases. Despite clinical success, widespread…”
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Vascular Endothelial Growth Factor Blockade Reduces Intratumoral Regulatory T Cells and Enhances the Efficacy of a GM-CSF–Secreting Cancer Immunotherapy by LI, Betty, LALANI, Alshad S, HARDING, Thomas C, LUAN, Bo, KOPRIVNIKAR, Kathryn, HUANTU, Guang, PRELL, Rodney, VAN ROEY, Melinda J, SIMMONS, Andrew D, JOOSS, Karin

“…Purpose: The purpose of the present study was to evaluate granulocyte macrophage colony-stimulating factor (GM-CSF)–secreting tumor cell immunotherapy in…”
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Intratumoral Coadministration of Hyaluronidase Enzyme and Oncolytic Adenoviruses Enhances Virus Potency in Metastatic Tumor Models by GANESH, Shanthi, GONZALEZ-EDICK, Melissa, GIBBONS, Douglas, VAN ROEY, Melinda, JOOSS, Karin

“…Purpose: Evaluate the codelivery of hyaluronidase enzyme with oncolytic adenoviruses to determine whether it improves the spread of the virus throughout…”
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Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor by JIANMIN LIN, LALANI, Alshad S, MITALO, Kari, JOOSS, Karin, HARDING, Thomas C, GONZALEZ, Melissa, WU, Wei-Wei, BO LUAN, GUANG HUAN TU, KOPRIVNIKAR, Kathryn, VANROEY, Melinda J, YULONG HE

“…The presence of metastases in regional lymph nodes is a strong indicator of poor patient survival in many types of cancer. It has recently been shown that the…”
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Relaxin-expressing, fiber chimeric oncolytic adenovirus prolongs survival of tumor-bearing mice by GANESH, Shanthi, MELISSA GONZALEZ EDICK, IDAMAKANTI, Neeraja, ABRAMOVA, Marina, VANROEY, Melinda, ROBINSON, Michael, YUN, Chae-Ok, JOOSS, Karin

“…Selective replication of oncolytic viruses in tumor cells provides a promising approach for the treatment of human cancers. One of the limitations observed…”
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Novel Immunocompetent Murine Tumor Model for Evaluation of Conditionally Replication-Competent (Oncolytic) Murine Adenoviral Vectors by ROBINSON, Michael, LI, Betty, YING GE, KO, Derek, YENDLURI, Satya, HARDING, Thomas, VANROEY, Melinda, SPINDLER, Katherine R, JOOSS, Karin

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Transduction of Dendritic Cells by DNA Viral Vectors Directs the Immune Response to Transgene Products in Muscle Fibers by Jooss, K, Yang, Y, Fisher, K J, Wilson, J M

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309 The role of tumor-draining lymph nodes in the tuning of systemic T cell immunity by CTLA-4 blockade is revealed by local delivery of tremelimumab in early-stage melanoma: data from a Phase-I trial by Notohardjo, Jessica, Pul, Kim van, Stam, Anita, Chondronasiou, Dafni, Lougheed, Sinead, Tol, Petrousjka van den, Jooss, Karin, Vuylsteke, Ronald, Eertwegh, Alfons van den, Gruijl, Tanja de

“…BackgroundThe sentinel lymph node (SLN) is the first node to receive lymphatic drainage from the primary tumor and the site where naïve T cells are first…”
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Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy by Nguyen, Minh C, Tu, Guang Huan, Koprivnikar, Kathryn E, Gonzalez-Edick, Melissa, Jooss, Karin U, Harding, Thomas C

“…A critical factor in clinical development of cancer immunotherapies is the identification of tumor-associated antigens that may be related to immunotherapy…”
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GM-CSF-secreting cancer immunotherapies: preclinical analysis of the mechanism of action by Simmons, Andrew D, Li, Betty, Gonzalez-Edick, Melissa, Lin, Carol, Moskalenko, Marina, Du, Thomas, Creson, Jennifer, VanRoey, Melinda J, Jooss, Karin

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting tumor cell immunotherapies have demonstrated long-lasting, and specific anti-tumor immune…”
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Lymphocyte Activation Gene-3 Fusion Protein Increases the Potency of a Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Cell Immunotherapy by LI, Betty, VAN ROEY, Melinda, TRIEBEL, Frederic, JOOSS, Karin

“…Purpose: The purpose of the present study was to evaluate granulocyte macrophage colony-stimulating factor (GM-CSF)-secreting tumor cell immunotherapy, which…”
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Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase by Stumptner-Cuvelette, Pamela, Jouve, Mabel, Helft, Julie, Dugast, Marc, Glouzman, Anne-Sophie, Jooss, Karin, Raposo, Graça, Benaroch, Philippe

“…Nef alters the cell surface expression of several immunoreceptors, which may contribute to viral escape. We show that Nef modifies major histocompatibility…”
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Efficacy of GM-CSF-producing tumor vaccine after docetaxel chemotherapy in mice bearing established Lewis lung carcinoma by Chu, Yiwei, Wang, Li-Xin, Yang, Guojun, Ross, Helen J, Urba, Walter J, Prell, Rodney, Jooss, Karin, Xiong, Sidong, Hu, Hong-Ming

“…In this report, we evaluated the efficacy of a GM-CSF-producing tumor vaccine given before and after docetaxel in mice bearing established lung tumors. Mice…”
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Enhanced gene transfer efficiency in the murine striatum and an orthotopic glioblastoma tumor model, using AAV-7- and AAV-8-pseudotyped vectors by Harding, Thomas C, Dickinson, Peter J, Roberts, Byron N, Yendluri, Satya, Gonzalez-Edick, Melissa, Lecouteur, Richard A, Jooss, Karin U

“…In this study, recombinant AAV vectors pseudotyped with viral capsids derived from AAV serotypes 7 and 8 were evaluated for gene transfer in the murine…”
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Enhancement of the anti-tumor efficacy of a GM-CSF–secreting tumor cell immunotherapy in preclinical models by cytosine arabinoside by Lin, Jian Min, Li, Betty, Rimmer, Eric, VanRoey, Melinda, Jooss, Karin

“…Objective Acute myeloid leukemia (AML) is a highly malignant neoplasm responsible for nearly 10,000 cancer-related deaths annually in the United States…”
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Successful Interference with Cellular Immune Responses to Immunogenic Proteins Encoded by Recombinant Viral Vectors by Sarukhan, A, Camugli, S, Gjata, B, von Boehmer, H, Danos, O, Jooss, K

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