Search Results - "Joo Chuan Tong"

Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein by Kam, Yiu‐Wing, Lum, Fok‐Moon, Teo, Teck‐Hui, Lee, Wendy W. L., Simarmata, Diane, Harjanto, Sumitro, Chua, Chong‐Long, Chan, Yoke‐Fun, Wee, Jin‐Kiat, Chow, Angela, Lin, Raymond T. P., Leo, Yee‐Sin, Le Grand, Roger, Sam, I‐Ching, Tong, Joo‐Chuan, Roques, Pierre, Wiesmüller, Karl‐Heinz, Rénia, Laurent, Rötzschke, Olaf, Ng, Lisa F. P.

“…Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. The immune…”
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Recent advances in computer-aided drug design by Song, Chun Meng, Lim, Shen Jean, Tong, Joo Chuan

“…Modern drug discovery is characterized by the production of vast quantities of compounds and the need to examine these huge libraries in short periods of time…”
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Predicting host tropism of influenza A virus proteins using random forest by Eng, Christine L P, Tong, Joo Chuan, Tan, Tin Wee

“…Majority of influenza A viruses reside and circulate among animal populations, seldom infecting humans due to host range restriction. Yet when some avian…”
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AllerHunter: a SVM-pairwise system for assessment of allergenicity and allergic cross-reactivity in proteins by Muh, Hon Cheng, Tong, Joo Chuan, Tammi, Martti T

“…Allergy is a major health problem in industrialized countries. The number of transgenic food crops is growing rapidly creating the need for allergenicity…”
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Predicting Zoonotic Risk of Influenza A Viruses from Host Tropism Protein Signature Using Random Forest by Eng, Christine L P, Tong, Joo Chuan, Tan, Tin Wee

“…Influenza A viruses remain a significant health problem, especially when a novel subtype emerges from the avian population to cause severe outbreaks in humans…”
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Distinct Host Tropism Protein Signatures to Identify Possible Zoonotic Influenza A Viruses by Eng, Christine L P, Tong, Joo Chuan, Tan, Tin Wee

“…Zoonotic influenza A viruses constantly pose a health threat to humans as novel strains occasionally emerge from the avian population to cause human…”
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T-Cell Epitope Prediction of Chikungunya Virus by Eng, Christine Loan Ping, Tan, Tin Wee, Tong, Joo Chuan

“…There has been a growing demand for vaccines against Chikungunya virus (CHIKV), and epitope-based vaccine is a promising solution. Identification of CHIKV…”
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Clustering HLA class I superfamilies using structural interaction patterns by Harjanto, Sumitro, Ng, Lisa F P, Tong, Joo Chuan

“…Human leukocyte antigen (HLA) class I molecules are critical components of the cell-mediated immune system that bind and present intracellular antigenic…”
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Immuno-biology of Chikungunya and implications for disease intervention by Kam, Yiu-Wing, Ong, Edward K.S., Rénia, Laurent, Tong, Joo-Chuan, Ng, Lisa F.P.

“…The re-emergence of Chikungunya fever, an old tropical infectious disease with new characteristics represents a major public health problem with severe social…”
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Health and disease phenotyping in old age using a cluster network analysis by Valenzuela, Jesus Felix, Monterola, Christopher, Tong, Victor Joo Chuan, Ng, Tze Pin, Larbi, Anis

“…Human ageing is a complex trait that involves the synergistic action of numerous biological processes that interact to form a complex network. Here we…”
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Effects of Cultural Tightness–Looseness and Social Network Density on Expression of Positive and Negative Emotions: A Large-Scale Study of Impression Management by Facebook Users by Liu, Pan, Chan, David, Qiu, Lin, Tov, William, Tong, Victor Joo Chuan

“…Using data from 13,789 Facebook users across U.S. states, this study examined the main effects of societal-level cultural tightness–looseness and its…”
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MPID-T2: a database for sequence―structure-function analyses of pMHC and TR/pMHC structures by JAVED MOHAMMED KHAN, HARISH REDDY CHERUKU, JOO CHUAN TONG, RANGANATHAN, Shoba

“…Sequence-structure-function information is critical in understanding the mechanism of pMHC and TR/pMHC binding and recognition. A database for…”
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Degree and centrality-based approaches in network-based variable selection: Insights from the Singapore Longitudinal Aging Study by Valenzuela, Jesus Felix Bayta, Monterola, Christopher, Tong, Victor Joo Chuan, Fülöp, Tamàs, Ng, Tze Pin, Larbi, Anis

“…We describe a network-based method to obtain a subset of representative variables from clinical data of subjects of the second Singapore Longitudinal Aging…”
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Methods and protocols for prediction of immunogenic epitopes by Tong, Joo Chuan, Tan, Tin Wee, Ranganathan, Shoba

“…T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity. Recently, there has been an influx of…”
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Functional and Structural Implications of the Complement Factor H Y402H Polymorphism Associated with Age-Related Macular Degeneration by Ormsby, Rebecca J, Ranganathan, Shoba, Tong, Joo Chuan, Griggs, Kim M, Dimasi, David P, Hewitt, Alex W, Burdon, Kathryn P, Craig, Jamie E, Hoh, Josephine, Gordon, David L

“…A Tyr-to-His (Y402H) sequence variant in the factor H (FH) and factor H-like protein (FHL-1) gene is strongly associated with an increased susceptibility for…”
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MPID-T: database for sequence-structure-function information on T-cell receptor/peptide/MHC interactions by Tong, Joo Chuan, Kong, Lesheng, Tan, Tin Wee, Ranganathan, Shoba

“…Normal adaptive immune responses operate under major histocompatibility complex (MHC) restriction by binding to specific, short antigenic peptides and…”
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Modeling the structure of bound peptide ligands to major histocompatibility complex by Tong, Joo Chuan, Tan, Tin Wee, Ranganathan, Shoba

“…In this article, we present a new technique for the rapid and precise docking of peptides to MHC class I and class II receptors. Our docking procedure consists…”
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In silico grouping of peptide/HLA class I complexes using structural interaction characteristics by Tong, Joo Chuan, Tan, Tin Wee, Ranganathan, Shoba

“…Motivation: Classification of human leukocyte antigen (HLA) proteins into supertypes underpins the development of epitope-based vaccines with wide population…”
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Understanding infectious agents from an in silico perspective by Tong, Joo Chuan, Ng, Lisa F.P.

“…Knowledge of infectious diseases now emerging from genomic, proteomic, epidemiological and clinical data can provide insights into the mechanisms of immune…”
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HLA class I restriction as a possible driving force for Chikungunya evolution by Tong, Joo Chuan, Simarmata, Diane, Lin, Raymond T P, Rénia, Laurent, Ng, Lisa F P

“…After two decades of quiescence, epidemic resurgence of Chikungunya fever (CHIKF) was reported in Africa, several islands in the Indian Ocean, South-East Asia…”
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