Search Results - "Jonsson, William O."

Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights by Jonsson, William O, Margolies, Nicholas S, Anthony, Tracy G

“…Dietary sulfur amino acid restriction, also referred to as methionine restriction, increases food intake and energy expenditure and alters body composition in…”
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Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction by Martinez, Wenceslao, Zhang, Qian, Linden, Melissa A, Schacher, Nate, Darvish, Sanna, Mirek, Emily T, Levy, Jordan L, Jonsson, William O, Anthony, Tracy G, Hamilton, Karyn L

“…Dietary interventions such as sulfur amino acid restriction (SAAR) target multiple drivers of aging, and show promise for preventing or delaying the onset of…”
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Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific by Jonsson, William O., Mirek, Emily T., Wek, Ronald C., Anthony, Tracy G.

“…Dietary removal of an essential amino acid (EAA) triggers the integrated stress response (ISR) in liver. Herein, we explored the mechanisms that activate the…”
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GCN2 is required to maintain core body temperature in mice during acute cold by Levy, Jordan L, Mirek, Emily T, Rodriguez, Esther M, Zalma, Brian, Burns, Jeffrey, Jonsson, William O, Sampath, Harini, Staschke, Kirk A, Wek, Ronald C, Anthony, Tracy G

“…Nonshivering thermogenesis in rodents requires macronutrients to fuel the generation of heat during hypothermic conditions. In this study, we examined the role…”
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Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex by Jonsson, William O, Margolies, Nicholas S, Mirek, Emily T, Zhang, Qian, Linden, Melissa A, Hill, Cristal M, Link, Christopher, Bithi, Nazmin, Zalma, Brian, Levy, Jordan L, Pettit, Ashley P, Miller, Joshua W, Hine, Christopher, Morrison, Christopher D, Gettys, Thomas W, Miller, Benjamin F, Hamilton, Karyn L, Wek, Ronald C, Anthony, Tracy G

“…Dietary sulfur amino acid restriction (SAAR) improves body composition and metabolic health across several model organisms in part through induction of the…”
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Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice by Lackey, Atreju I, Chen, Tina, Zhou, Yin X, Bottasso Arias, Natalia M, Doran, Justine M, Zacharisen, Sophia M, Gajda, Angela M, Jonsson, William O, Córsico, Betina, Anthony, Tracy G, Joseph, Laurie B, Storch, Judith

“…Intestinal-fatty acid binding protein (IFABP; FABP2) is a 15-kDa intracellular protein abundantly present in the cytosol of the small intestinal (SI)…”
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Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism by Jonsson, William O, Ponette, Jonathan, Horwath, Oscar, Rydenstam, Tomas, Söderlund, Karin, Ekblom, Björn, Azzolini, Michele, Ruas, Jorge L, Blomstrand, Eva

“…Administration of branched-chain amino acids (BCAA) has been suggested to enhance mitochondrial biogenesis, including levels of PGC-1α, which may, in turn,…”
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Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force by Liu, Zhengye, Chaillou, Thomas, Santos Alves, Estela, Mader, Theresa, Jude, Baptiste, Ferreira, Duarte M. S., Hynynen, Heidi, Cheng, Arthur J., Jonsson, William O., Pironti, Gianluigi, Andersson, Daniel C., Kenne, Ellinor, Ruas, Jorge L., Tavi, Pasi, Lanner, Johanna T.

“…The hypoxia‐inducible nuclear‐encoded mitochondrial protein NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4‐like 2 (NDUFA4L2) has been demonstrated to…”
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Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice by Pettit, Ashley P, Jonsson, William O, Bargoud, Albert R, Mirek, Emily T, Peelor, 3rd, Frederick F, Wang, Yongping, Gettys, Thomas W, Kimball, Scot R, Miller, Benjamin F, Hamilton, Karyn L, Wek, Ronald C, Anthony, Tracy G

“…The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via…”
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Circulating metabolite homeostasis achieved through mass action by Li, Xiaoxuan, Hui, Sheng, Mirek, Emily T., Jonsson, William O., Anthony, Tracy G., Lee, Won Dong, Zeng, Xianfeng, Jang, Cholsoon, Rabinowitz, Joshua D.

“…Homeostasis maintains serum metabolites within physiological ranges. For glucose, this requires insulin, which suppresses glucose production while accelerating…”
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Age modulates liver responses to asparaginase-induced amino acid stress in mice by Nikonorova, Inna A., Zhu, Qiaoqiao, Signore, Christina C., Mirek, Emily T., Jonsson, William O., Kong, Bo, Guo, Grace L., Belden, William J., Anthony, Tracy G.

“…Asparaginase is an amino acid–depleting agent used to treat blood cancers. Metabolic complications due to asparaginase affect liver function in humans. To…”
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Kinetic proteomics identifies targeted changes in liver metabolism and the ribo-interactome by dietary sulfur amino acid restriction by Jonsson, William O., Borowik, Agnieszka K., Pranay, Atul, Kinter, Michael T., Mirek, Emily T., Levy, Jordan L., Snyder, Elizabeth M., Miller, Benjamin F., Anthony, Tracy G.

“…Dietary sulfur amino acid restriction (SAAR) protects against diet-induced obesity, extends healthspan, and coincides with an overall reduction in hepatic…”
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Dietary Amino Acid Restriction and the Integrated Stress Response by Jonsson, William O

“…Dietary amino acid restriction produces beneficial health effects in a range of experimental animal models and is characterized by an overall reduction in…”
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