Search Results - "Jonson, Anna C"

Strategy for large-scale isolation of enantiomers in drug discovery by Leek, Hanna, Thunberg, Linda, Jonson, Anna C., Öhlén, Kristina, Klarqvist, Magnus

“…•SFC is a superior separation technique for isolation of enantiomers.•A crucial factor for success in SFC is solubility of the compound in the mobile…”
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Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging by Sardana, Malvika, Breuil, Louise, Goutal, Sébastien, Goislard, Maud, Kondrashov, Mikhail, Marchal, Etienne, Besson, Florent L, Dugave, Christophe, Wrigley, Gail, Jonson, Anna C, Kuhnast, Bertrand, Schou, Magnus, Tournier, Nicolas, Elmore, Charles S, Caillé, Fabien

“…Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a…”
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Chiral Chromatographic Isolation on Milligram Scale of the Human African Trypanosomiasis Treatment d- and l‑Eflornithine by Boberg, Mikael, Jonson, Anna C, Leek, Hanna, Jansson-Löfmark, Rasmus, Ashton, Michael

“…Eflornithine is a recommended treatment against the otherwise fatal parasitic disease late stage human African trypanosomiasis (HAT), also known as Gambian…”
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Unexpected carbonate salt formation during isolation of an enantiopure intermediate by supercritical fluid chromatography by Thunberg, Linda, Carlsson, Anna-Carin C., Jonson, Anna C., Pithani, Subhash, Aurell, Carl-Johan, Leek, Hanna

“…•Resolution of enantiomers by supercritical fluid chromatography.•Turning an inefficient chromatographic method to a sustainable one.•Recycling of mobile phase…”
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Delivering the promise of SFC: a case study by Lindskog, Maria A., Nelander, Hanna, Jonson, Anna C., Halvarsson, Torbjörn

“…•Combining SFC with MS creates a powerful tool for large-scale purification.•A research scale laboratory built to handle multigram amounts can extend limits in…”
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Saccharin Aza BioisosteresSynthesis and Preclinical Property Comparisons by Chen, Yantao, Aurell, Carl-Johan, Pettersen, Anna, Lewis, Richard J, Hayes, Martin A, Lepistö, Matti, Jonson, Anna C, Leek, Hanna, Thunberg, Linda

“…Saccharin is a well-known scaffold in drug discovery. Herein, we report the synthesis and preclinical property comparisons of three bioisosteres of saccharin:…”
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Expanding the Chemical Space of Transforming Growth Factor‑β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives by Längle, Daniel, Wojtowicz-Piotrowski, Stephanie, Priegann, Till, Keller, Niklas, Wesseler, Fabian, Reckzeh, Elena S., Steffens, Karsten, Grathwol, Christoph, Lemke, Jana, Flasshoff, Maren, Näther, Christian, Jonson, Anna C., Link, Andreas, Koch, Oliver, Di Guglielmo, Gianni M., Schade, Dennis

“…The TGFβ type II receptor (TβRII) is a central player in all TGFβ signaling downstream events, has been linked to cancer progression, and thus, has emerged as…”
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Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRAS G12C Inhibitors by Nikitidis, Grigorios, Carlsson, Anna-Carin C., Karlsson, Staffan, Campbell, Andrew D., Cook, Calum, Dai, Kuangchu, Emtenäs, Hans, Jonson, Anna C., Leek, Hanna, Malmgren, Marcus, Moravčík, Štefan, Pithani, Subhash, Tatton, Matthew R., Zhao, Hucheng, Öhlén, Kristina

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