Search Results - "Jonscher, Karen"

Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver by Blaber, Elizabeth A., Pecaut, Michael J., Jonscher, Karen R.

“…Increased oxidative stress is an unavoidable consequence of exposure to the space environment. Our previous studies showed that mice exposed to space for 13.5…”
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Spaceflight Activates Lipotoxic Pathways in Mouse Liver by Jonscher, Karen R, Alfonso-Garcia, Alba, Suhalim, Jeffrey L, Orlicky, David J, Potma, Eric O, Ferguson, Virginia L, Bouxsein, Mary L, Bateman, Ted A, Stodieck, Louis S, Levi, Moshe, Friedman, Jacob E, Gridley, Daila S, Pecaut, Michael J

“…Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations…”
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Developmental origins of NAFLD: a womb with a clue by Wesolowski, Stephanie R., Kasmi, Karim C. El, Jonscher, Karen R., Friedman, Jacob E.

“…Key Points Exposure to maternal overnutrition or undernutrition increases susceptibility to NAFLD in childhood and hastens progression to NASH across the…”
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Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention by Jonscher, Karen R, Chowanadisai, Winyoo, Rucker, Robert B

“…Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ…”
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Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation by Kendrick, Agnieszka A, Choudhury, Mahua, Rahman, Shaikh M, McCurdy, Carrie E, Friederich, Marisa, Van Hove, Johan L K, Watson, Peter A, Birdsey, Nicholas, Bao, Jianjun, Gius, David, Sack, Michael N, Jing, Enxuan, Kahn, C Ronald, Friedman, Jacob E, Jonscher, Karen R

“…Acetylation has recently emerged as an important mechanism for controlling a broad array of proteins mediating cellular adaptation to metabolic fuels…”
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Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? by Pecaut, Michael J, Mao, Xiao Wen, Bellinger, Denise L, Jonscher, Karen R, Stodieck, Louis S, Ferguson, Virginia L, Bateman, Ted A, Mohney, Robert P, Gridley, Daila S

“…The Space Shuttle Atlantis launched on its final mission (STS-135) on July 8, 2011. After just under 13 days, the shuttle landed safely at Kennedy Space Center…”
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MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals by Jin, Lei, Waterman, Paul M., Jonscher, Karen R., Short, Cindy M., Reisdorph, Nichole A., Cambier, John C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes by Zhang, Li, Jonscher, Karen R., Zhang, Zuyuan, Xiong, Yi, Mueller, Ryan S., Friedman, Jacob E., Pan, Chongle

“…The immune system of some genetically susceptible children can be triggered by certain environmental factors to produce islet autoantibodies (IA) against…”
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1173-P: Maternally Supplemented PQQ Targets Ceramide Metabolism in Offspring to Blunt Developmental Programming of NAFLD by MANDALA, ASHOK, TEAGUE, APRIL M., JANSSEN, RACHEL, PATIL, NIKHIL, JOSHI, ADITYA D., FRIEDMAN, JACOB E., JONSCHER, KAREN R.

“…Maternal obesity is a key risk factor for pediatric nonalcoholic fatty liver disease (NAFLD). Using a mouse model of Western-style diet (WD)-induced maternal…”
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1855-P: Early Life Dysbiosis in Offspring of Obese Mice Promotes Hepatic Macrophage Dysfunction by JONSCHER, KAREN R., JANSSEN, RACHEL, KOVATS, SUSAN, MCMAHAN, RACHEL, FRIEDMAN, JACOB E.

“…Maternal obesity is associated with increased risk for development of metabolic disease in the next generation. Obesity, type 2 diabetes, and nonalcoholic…”
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Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response by Sugino, Kameron Y, Janssen, Rachel C, McMahan, Rachel H, Zimmerman, Chelsea, Friedman, Jacob E, Jonscher, Karen R

“…Maternal obesity and/or Western diet (WD) is associated with an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in…”
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Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD by Mandala, Ashok, Dobrinskikh, Evgenia, Janssen, Rachel C, Fiehn, Oliver, D'Alessandro, Angelo, Friedman, Jacob E, Jonscher, Karen R

“…Maternal obesity and consumption of a high-fat diet significantly elevate risk for pediatric nonalcoholic fatty liver disease (NAFLD), affecting 10% of…”
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Early PQQ supplementation has persistent long‐term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice by Jonscher, Karen R., Stewart, Michael S., Alfonso‐Garcia, Alba, DeFelice, Brian C., Wang, Xiaoxin X., Luo, Yuhuan, Levi, Moshe, Heerwagen, Margaret J. R., Janssen, Rachel C., Houssaye, Becky A., Wiitala, Ellen, Florey, Garrett, Jonscher, Raleigh L., Potma, Eric O., Fiehn, Oliver, Friedman, Jacob E.

“…Nonalcoholic fatty liver disease (NAFLD) is widespread in adults and children. Early exposure to maternal obesity or Western‐style diet (WD) increases…”
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Assessment of Fatty Liver in Models of Disease Programming by Bruce, Kimberley D, Jonscher, Karen R

“…Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease worldwide and is present in a third of the general…”
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Analysis of 25 underivatized amino acids in human plasma using ion-pairing reversed-phase liquid chromatography/time-of-flight mass spectrometry by Armstrong, Michael, Jonscher, Karen, Reisdorph, Nichole A.

“…Amino acids in biological fluids have previously been shown to be detectable using liquid chromatography/electrospray ionization mass spectrometry (LC/ESI‐MS)…”
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Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat by Choudhury, Mahua, Jonscher, Karen R, Friedman, Jacob E

“…Aging is associated with various metabolic disorders that may have their origin in the liver, including non-alcoholic fatty liver disease, obesity, type 2…”
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Mindfulness-Based Stress Reduction for Military Women With Chronic Pelvic Pain: A Feasibility Study by Crisp, Carol D, Hastings-Tolsma, Marie, Jonscher, Karen R

“…One of the most common reasons women seek gynecologic health care services is for chronic pelvic pain (CPP) and women in the military are no exception. For…”
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Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver by Jonscher, Karen R, Alfonso-Garcia, Alba, Suhalim, Jeffrey L, Orlicky, David J, Potma, Eric O, Ferguson, Virginia L, Bouxsein, Mary L, Bateman, Ted A, Stodieck, Louis S, Levi, Moshe, Friedman, Jacob E, Gridley, Daila S, Pecaut, Michael J

“…[This corrects the article DOI: 10.1371/journal.pone.0152877.]…”
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Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions by Jonscher, Karen R, Bruce, Kimberley D

“…Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disorders ranging from simple steatosis to steatosis with inflammation and fibrosis. NAFLD…”
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Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver by Sugino, Kameron Y, Mandala, Ashok, Janssen, Rachel C, Gurung, Sunam, Trammell, MaJoi, Day, Michael W, Brush, Richard S, Papin, James F, Dyer, David W, Agbaga, Martin-Paul, Friedman, Jacob E, Castillo-Castrejon, Marisol, Jonscher, Karen R, Myers, Dean A

“…Maternal consumption of a high-fat, Western-style diet (WD) disrupts the maternal/infant microbiome and contributes to developmental programming of the immune…”
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