Search Results - "Jonkman, Jan H.G"

Exploring the boundaries of bioanalytical quantitative LC–MS–MS by Lagerwerf, Fija M, van Dongen, William D, Steenvoorden, Ruud J.J.M, Honing, Maarten, Jonkman, Jan H.G

“…In this article, the boundaries of quantitative high-performance liquid chromatography coupled with tandem mass spectrometry (LC–MS–MS) as a bioanalytical tool…”
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The Effect of Telmisartan on the Steady-State Pharmacokinetics of Digoxin in Healthy Male Volunteers by Stangier, Joachim, Su, Chung-An P. F., Hendriks, Maarten G. C., van Lier, Jan J., Sollie, Frans A. E., Oosterhuis, Berend, Jonkman, Jan H.G.

“…A multiple‐dose, open‐label, two‐period, crossover randomized study was conducted in 12 healthy male volunteers to investigate the effect of multiple‐dose…”
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Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects by Weber, C, Schmitt, R, Birnboeck, H, Hopfgartner, G, van Marle, S P, Peeters, P A, Jonkman, J H, Jones, C R

“…Bosentan (Ro 47-0203) is a potent and mixed ETA-and ETB-receptor antagonist. Its activity has been studied in a variety of preclinical disease models. Two…”
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Absorption, Metabolism, and Excretion of Intravenously and Orally Administered [14C]Telmisartan in Healthy Volunteers by Stangier, Joachim, Schmid, Jochen, Türck, Dietrich, Switek, Heinz, Verhagen, Aalt, Peeters, Pierre A. M., van Marle, Sjoerd P., Tamminga, Wim J., Sollie, Frans A. E., Jonkman, Jan H. G.

“…The study was conducted in healthy male volunteers to evaluate the absorption, metabolic pattern, and mode of elimination of telmisartan, a nonpeptide…”
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Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects by Huang, M L, Van Peer, A, Woestenborghs, R, De Coster, R, Heykants, J, Jansen, A A, Zylicz, Z, Visscher, H W, Jonkman, J H

“…The pharmacokinetics of a novel antipsychotic agent, risperidone, and the prolactin response were studied in 12 dextromethorphan-phenotyped healthy men after…”
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Multiple-Dose Pharmacokinetics, Safety, and Tolerability of Bosentan, an Endothelin Receptor Antagonist, in Healthy Male Volunteers by Weber, Cornelia, Schmitt, Rita, Birnboeck, Herbert, Hopfgartner, Gerard, Eggers, Herwig, Meyer, Joseph, van Marle, Sjoerd, Viischer, Henk W., Jonkman, Jan H. G.

“…The multiple‐dose pharmacokinetics, safety, and tolerability of oral bosentan, a selective endothelin receptor antagonist, were investigated in healthy male…”
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Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study by TAMMINGA, Wim J, WEMER, Johan, OOSTERHUIS, Berend, DE BOER, Anthonius, VRANCKX, Stan, DRENTH, Ben F. H, DE ZEEUW, Rokus A, DE LEIJ, Lou F. M. H, JONKMAN, Jan H. G

“…The aim of the current retrospective study was to assess the influence of polymorphic drug metabolism as assessed by genotyping, on the on the utilisation of…”
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Rosiglitazone: No Effect on Erythropoiesis or Premature Red Cell Destruction by DOGTEROM, PETER, JONKMAN, JAN H.G, VALLANCE, SUSAN E

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Inhibitory Effect of Telmisartan on the Blood Pressure Response to Angiotensin II Challenge by Stangier, Joachim, Su, Chung-An P. F, van Heiningen, Pauline N. M, Meinicke, Thomas, van Lier, Jan J, de Bruin, Henrieke, Tamminga, Wim J, Jonkman, Jan H. G

“…Telmisartan is a new angiotensin receptor antagonist possessing potent, selective, and insurmountable inhibitory activity specific to the angiotensin II type 1…”
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Single-dose subcutaneous administration of recombinant human parathyroid hormone [rhPTH(1-84)] in healthy postmenopausal volunteers by Schwieter, Hendrik Reinier, Groen, Edwin W. J., Sollie, Frans A. E., Jonkman, Jan H. G.

“…Background Parathyroid hormone [PTH(1–84)] is intended for treatment of osteoporosis because it stimulates new bone formation of normal structure and…”
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The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers by Seaber, Emma J., Peck, Richard W., Smith, Deborah A., Allanson, John, Hefting, Nanco R., Van Lier, Jan J., Sollie, Frans A. E., Wemer, Johan, Jonkman, Jan H. G.

“…Aims Zolmitriptan (Zomig (formerly 311C90)) is a novel 5‐HT1B/1D receptor agonist developed for the acute oral treatment of migraine. A highly sensitive…”
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A Comparison of the Pharmacokinetics and Tolerability of Riluzole after Repeat Dose Administration in Healthy Elderly and Young Volunteers by Liboux, Aimé Le, Cachia, Jean-Paul, Kirkesseli, Stéphane, Gautier, Jean-Yves, Guimart, Colette, Montay, Guy, Peeters, Pierre A. M., Groen, Edwin, Jonkman, Jan H. G., Wemer, Johannes

“…The pharmacokinetics and tolerability of the novel antiexcitatory agent, riluzole, were compared in 18 healthy elderly and 18 healthy gender‐ and…”
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An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19 by TAMMINGA, Wim J, WEMER, Johan, OOSTERHUIS, Berend, BRAKENHOFF, Jan P. G, GERRITS, Mireille G. F, DE ZEEUW, Rokus A, DE LEIJ, Lou F. M. H, JONKMAN, Jan H. G

“…A method for simultaneous phenotyping and genotyping for CYP2D6 and CYP2C19 was tested. Six healthy volunteers were selected (three extensive and three poor…”
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Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra‐individual reproducibility and occurrence of adverse events by Tamminga, Wim J., Wemer, Johan, Oosterhuis, Berend, Wieling, Jaap, Touw, Daan J., De Zeeuw, Rokus A., De Leij, Lou F. M. H., Jonkman, Jan H. G.

“…Aims  To further evaluate mephenytoin as a probe for CYP2C19 phenotyping. Methods  Healthy subjects (n = 2638) were phenotyped using the urinary…”
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Evaluation of analytical and clinical performance of a dual-probe phenotyping method for CYP2D6 polymorphism and CYP3A4 activity screening by WIELING, J, TAMMINGA, W. J, SAKIMAN, E. P, OOSTERHUIS, B, WEMER, J, JONKMAN, J. H. G

“…A bioanalytical method for the determination of dextromethorphan (DEX) and its metabolites dextrorphan (DTX), 3-methoxymorphinan (3MM), and 3-hydroxymorphinan…”
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Controversies in bioequivalence studies by STEINIJANS, V. K, HAUSCHKE, D, JONKMAN, J. H. G

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Steady-State Pharmacodynamics and Pharmacokinetics of Warfarin in the Presence and Absence of Telmisartan in Healthy Male Volunteers by Stangier, Joachim, Su, Chung-An P. F., Hendriks, Maarten G. C., van Lier, Jan J., Sollie, Frans A. E., Oosterhuis, Berend, Jonkman, Jan H. G.

“…The effects of multiple‐dose telmisartan on the steady‐state pharmacodynamics and pharmacokinetics of warfarin were assessed in 12 healthy young males in an…”
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Clopidogrel, a novel antiplatelet agent, and digoxin: absence of pharmacodynamic and pharmacokinetic interaction by Peeters, P A, Crijns, H J, Tamminga, W J, Jonkman, J H, Dickinson, J P, Necciari, J

“…The safety, and the pharmacodynamic and pharmacokinetic compatibility of clopidogrel, 75 mg daily, with the cardiac glycoside digoxin, were assessed in 12…”
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Absorption and mass balance of piperonyl butoxide following an 8-h dermal exposure in human volunteers by Selim, Sami, Preiss, Frederick J., Gabriel, Karl L., Jonkman, Jan H.G., Osimitz, Tom G.

“…Dermal absorption, metabolism and excretion of piperonyl butoxide (PBO) was studied using 14C-PBO either by itself as a 3% (w/w) solution in isopropyl alcohol…”
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The influence of age on the pharmacokinetics of the antiepileptic agent oxcarbazepine by van Heiningen, P N, Eve, M D, Oosterhuis, B, Jonkman, J H, de Bruin, H, Hulsman, J A, Richens, A, Jensen, P K

“…The disposition of oxcarbazepine was studied in 12 young and 12 elderly healthy male and 12 young and 12 elderly healthy female volunteers, with emphasis on…”
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